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    ADAM12 as marker for 2nd trimester Down Syndrome
    2.
    发明公开
    ADAM12 as marker for 2nd trimester Down Syndrome 有权
    ADAM12 als MarkerfürDown-Syndrom im 2. Trimenon

    公开(公告)号：EP2175277A1

    公开(公告)日：2010-04-14

    申请号：EP10150452.0

    申请日：2005-05-18

    申请人： Københavns Universitet ,  Statens Serum Institut ,  Harold Wood Hospital

    发明人： Wewer, Ulla M. ,  Nørgaard-Pedersen, Bent ,  Christiansen, Michael ,  Laigaard, Jennie ,  Fröhlich, Camilla ,  Spencer, Kevin

    IPC分类号： G01N33/68 ,  C12Q1/68

    CPC分类号： G01N33/689 ,  G01N2333/4745 ,  G01N2333/96486 ,  G01N2800/36 ,  G01N2800/368 ,  G01N2800/385 ,  G01N2800/387 ,  Y10T436/143333

    摘要： The present inventors describe ADAM12 as an important indicator of foetal and placental development, function and changes in the level of ADAM12 may reflect the presence, classification or progression of disease. The present invention provides a method, an assay and a kit for providing an indication of Down Syndrome.
    The present application demonstrates that ADAM12 is reduced in first trimester and increased in second trimester Down Syndrome pregnancies. ADAM12 may thus serve as a maternal serum risk marker for fetal disease. It is thus an object of the present invention to provide an improvement of the existing marker tests that exhibits a decreased false positive rate or improved detection rate of chromosomal disease or adverse pregnancy outcome.

    摘要翻译： 本发明人描述了ADAM12作为胎儿和胎盘发育的重要指标，ADAM12水平的功能和变化可能反映疾病的存在，分类或进展。 本发明提供了一种用于提供唐氏综合征指征的方法，测定和试剂盒。 本申请表明，ADAM12在妊娠前期减少，妊娠晚期唐氏综合征妊娠增加。 因此ADAM12可作为胎儿疾病的母体血清风险标志物。 因此，本发明的目的是提供现有的标志物测试的改进，其显示出降低的假阳性率或改善的染色体病或不良妊娠结局的检出率。