公开(公告)号：EP0235957B1

公开(公告)日：1993-04-07

申请号：EP87300962.5

申请日：1987-02-03

申请人： KABUSHIKI KAISHA YAKULT HONSHA

发明人： Nagai, Yoshitaka ,  Takamizawa, Koutaro ,  Tanaka, Ryuichiro ,  Takayama, Hiroo ,  Sakurai, Toshizo ,  Mutai, Masahiko

IPC分类号： A61K31/20

CPC分类号： A61K31/20 ,  Y02A50/469

摘要： Botulinus toxin neutraliser comprises a fatty acid(s) (I) having at least 12C. Pref. (I) is a satd. fatty acid having a straight chain and 16-22C.

公开(公告)号：EP0196917A3

公开(公告)日：1988-01-13

申请号：EP86302416

申请日：1986-04-01

申请人： KABUSHIKI KAISHA YAKULT HONSHA

发明人： Tanaka, Ryuichiro ,  Takamizawa, Koutaro ,  Takayama, Hiroo ,  Sakurai, Toshizo ,  Mada, Mitsuo ,  Mutai, Masahiko

IPC分类号： A61K35/30 ,  A61K37/22 ,  C07H15/04

CPC分类号： C07H15/10 ,  A61K31/00 ,  A61K35/20 ,  Y02A50/469 ,  Y10S514/823

摘要： A botulinus toxin neutralizer comprises (a) heat-treated fat globule membranes of animal milk or (b) gangliosides isolated from fat globule membranes of animal milk. The neutralizer (a) can be prepared from a material containing fat globules of animal milk by fractionating the material to separate the membranes of the fat globules, and subjecting the separated fat globule membranes to heat treatment. The neutralizer (b) can be prepared from a material containing fat globules of animal milk by fractionating the material to separate tne membranes of the fat globules, and isolating gangliosides from the separated globule membranes.

公开(公告)号：EP0196917A2

公开(公告)日：1986-10-08

申请号：EP86302416.2

申请日：1986-04-01

申请人： KABUSHIKI KAISHA YAKULT HONSHA

发明人： Tanaka, Ryuichiro ,  Takamizawa, Koutaro ,  Takayama, Hiroo ,  Sakurai, Toshizo ,  Mada, Mitsuo ,  Mutai, Masahiko

IPC分类号： A61K35/30 ,  A61K37/22 ,  C07H15/04

CPC分类号： C07H15/10 ,  A61K31/00 ,  A61K35/20 ,  Y02A50/469 ,  Y10S514/823

摘要： A botulinus toxin neutralizer comprises (a) heat-treated fat globule membranes of animal milk or (b) gangliosides isolated from fat globule membranes of animal milk. The neutralizer (a) can be prepared from a material containing fat globules of animal milk by fractionating the material to separate the membranes of the fat globules, and subjecting the separated fat globule membranes to heat treatment. The neutralizer (b) can be prepared from a material containing fat globules of animal milk by fractionating the material to separate tne membranes of the fat globules, and isolating gangliosides from the separated globule membranes.

公开(公告)号：EP0196917B1

公开(公告)日：1991-10-16

申请号：EP86302416.2

申请日：1986-04-01

申请人： KABUSHIKI KAISHA YAKULT HONSHA

发明人： Tanaka, Ryuichiro ,  Takamizawa, Koutaro ,  Takayama, Hiroo ,  Sakurai, Toshizo ,  Mada, Mitsuo ,  Mutai, Masahiko

IPC分类号： A61K35/30 ,  A61K37/22 ,  C07H15/04

CPC分类号： C07H15/10 ,  A61K31/00 ,  A61K35/20 ,  Y02A50/469 ,  Y10S514/823

摘要： A botulinus toxin neutralizer comprising heat-treated fat globule membranes of animal milk or gangliosides isolated from fat globule membranes of animal milk. The neutralizer of the former nature is prepared from a material containing fat globules of animal milk by fractionating the material for separating the membranes of the fat globules from the rest of the material, and subjecting the separated fat globule membranes to heat treatment. The neutralizer of the former nature is prepared from a material containing fat globules by fractionating the material for separating the membranes of the fat globules from the rest of the material, and isolating gangliosides from the globule membranes.

公开(公告)号：EP0235957A3

公开(公告)日：1990-01-17

申请号：EP87300962.5

申请日：1987-02-03

申请人： KABUSHIKI KAISHA YAKULT HONSHA

发明人： Nagai, Yoshitaka ,  Takamizawa, Koutaro ,  Tanaka, Ryuichiro ,  Takayama, Hiroo ,  Sakurai, Toshizo ,  Mutai, Masahiko

IPC分类号： A61K31/20

CPC分类号： A61K31/20 ,  Y02A50/469

摘要： A botulinus toxin neutralizer comprises at least one fatty acid having at least 12 carbon atoms. Such a fatty acid may be a saturated fatty acid such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid or behenic acid, or an unsaturated fatty acid such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinus toxin and, when encountering botulinus toxin in the human body, it combines directly with the toxin and prevents the toxin from combining with the neuromuscular tissues of the human body. Hence the neutralizer prevents the outbreak of botulism. The toxin thus neutralized and affixed to the botulinus toxin is excreted from the human body. The botulinus toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly than the known antitoxin of ganglioside GTlb produced from bovine brain.

公开(公告)号：EP0235957A2

公开(公告)日：1987-09-09

申请号：EP87300962.5

申请日：1987-02-03

申请人： KABUSHIKI KAISHA YAKULT HONSHA

发明人： Nagai, Yoshitaka ,  Takamizawa, Koutaro ,  Tanaka, Ryuichiro ,  Takayama, Hiroo ,  Sakurai, Toshizo ,  Mutai, Masahiko

IPC分类号： A61K31/20

CPC分类号： A61K31/20 ,  Y02A50/469

摘要： A botulinus toxin neutralizer comprises at least one fatty acid having at least 12 carbon atoms. Such a fatty acid may be a saturated fatty acid such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid or behenic acid, or an unsaturated fatty acid such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinus toxin and, when encountering botulinus toxin in the human body, it combines directly with the toxin and prevents the toxin from combining with the neuromuscular tissues of the human body. Hence the neutralizer prevents the outbreak of botulism. The toxin thus neutralized and affixed to the botulinus toxin is excreted from the human body. The botulinus toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly than the known antitoxin of ganglioside GTlb produced from bovine brain.

摘要翻译： 肉毒毒素中和剂包含具有至少12℃的脂肪酸（I）。 县。 （I）是一个satd 具有直链的脂肪酸和16-22℃。