公开(公告)号：EP2283130A4

公开(公告)日：2012-10-10

申请号：EP09726733

申请日：2009-04-03

申请人： KANE BIOTECH INC

发明人： MADHYASTHA SRINIVASA ,  GAWANDE PURUSHOTTAM ,  LOVETRI KAREN ,  YAKANDAWALA NANDADEVA ,  KAPLAN JEFFREY B

IPC分类号： C12N9/58 ,  A61K31/513 ,  A61K38/46 ,  A61K38/47 ,  A61K38/48 ,  A61L15/38 ,  A61L15/46 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61P1/02 ,  A61P17/02 ,  A61P31/00 ,  B05D1/02 ,  C12N9/00 ,  C12N9/22 ,  C12N9/24

CPC分类号： A61K31/513 ,  A61K38/465 ,  A61K38/47 ,  A61K38/482 ,  A61L15/38 ,  A61L15/46 ,  A61L29/16 ,  A61L2300/204 ,  A61L2300/254 ,  A61L2300/404 ,  A61L2300/45 ,  C12Y301/21001 ,  C12Y302/01052 ,  C12Y304/21064 ,  A61K2300/00

摘要： The present invention provides antibiofilm composition comprising two or more agents selected from the group consisting of DispersinB(TM), 5-Fluorouracil, Deoxyribonuclease I and Proteinase K for preventing growth and proliferation of biofilm-embedded microorganisms in wound care, oral care, and disease-related infections and methods of treatment in mammals. The invention further provides methods for preparing medical devices, and wound care devices using an antibiofilm composition comprising two or more antimicrobial agents selected from the group consisting of DispersinB(TM), 5-Fluorouracil, Deoxyribonuclease I and Proteinase K.

公开(公告)号：EP3160234A4

公开(公告)日：2018-01-24

申请号：EP15810908

申请日：2015-06-26

申请人： KANE BIOTECH INC

发明人： GAWANDE PURUSHOTTAM V ,  LOVETRI KAREN ,  YAKANDAWALA NANDADEVA ,  FROEHLICH GORD ,  MADHYASTHA SRINIVASA

IPC分类号： A01N59/16 ,  A01N37/04 ,  A01N37/44 ,  A01P1/00 ,  A61B3/125 ,  A61C11/00 ,  A61K8/27 ,  A61K8/362 ,  A61K8/365 ,  A61K8/44 ,  A61K9/00 ,  A61K31/194 ,  A61K31/198 ,  A61K33/30 ,  A61K45/06 ,  A61L2/16 ,  A61L12/08 ,  A61P31/00 ,  A61Q3/00 ,  A61Q17/00

CPC分类号： A61K8/44 ,  A01N37/04 ,  A01N37/44 ,  A01N59/16 ,  A61B3/125 ,  A61C11/005 ,  A61K8/27 ,  A61K8/362 ,  A61K8/365 ,  A61K9/0048 ,  A61K31/194 ,  A61K31/198 ,  A61K33/30 ,  A61K45/06 ,  A61K2800/70 ,  A61Q3/00 ,  A61Q17/005 ,  A61K2300/00 ,  A01N37/36

摘要： Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.

公开(公告)号：EP1906736A4

公开(公告)日：2012-08-08

申请号：EP06700639

申请日：2006-01-20

申请人： KANE BIOTECH INC

发明人： MADHYASTHA SRINIVASA

IPC分类号： A01N63/00 ,  A01N47/44 ,  A01P1/00 ,  A61L2/16 ,  A61L31/08 ,  A61L31/16

CPC分类号： A61L29/16 ,  A01N47/44 ,  A61K31/155 ,  A61K38/17 ,  A61L2/16 ,  A61L2/18 ,  A61L2/22 ,  A61L12/082 ,  A61L12/141 ,  A61L12/145 ,  A61L27/34 ,  A61L29/044 ,  A61L29/085 ,  A61L2300/206 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/42 ,  A01N37/46 ,  A01N2300/00 ,  A01N61/00 ,  C08L89/00 ,  A61K2300/00

摘要： The present invention provides compositions for preventing growth and proliferation of biofilm embedded microorganisms on devices comprising: (a) a cationic polypeptide and (b) a bis-guanide or a salt thereof. The invention further provides methods for preparing medical devices with such compositions.

公开(公告)号：EP2964235A4

公开(公告)日：2016-11-09

申请号：EP14761205

申请日：2014-03-06

申请人： KANE BIOTECH INC

发明人： GAWANDE PURUSHOTTAM V ,  LOVETRI KAREN ,  YAKANDAWALA NANDADEVA ,  FROELICH GORD ,  MADHYASTHA SRINIVASA

IPC分类号： A61K31/194 ,  A23B4/20 ,  A23L3/3463 ,  A23L3/358 ,  A61K31/198 ,  A61K33/30 ,  A61P17/02 ,  A61P31/02 ,  A61P31/04 ,  A61P31/10

CPC分类号： A23B4/027 ,  A23B4/20 ,  A23B4/24 ,  A23B7/154 ,  A23B7/157 ,  A23L3/3463 ,  A23L3/3508 ,  A23L3/358 ,  A23V2002/00 ,  A61K31/194 ,  A61K31/198 ,  A61K33/30 ,  A61K45/06 ,  Y02A40/943 ,  A61K2300/00

摘要： Compositions comprising chelating agents, metal ion salts, gelling agents or a buffer, antimicrobials, antibiofilm agents and a pH adjuster or a buffer for the prevention and treatment of wound infections and food-borne diseases involving bacterial biofilms are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive wound infection associated bacteria occurring in polymicrobial biofilms. The composition may be in the form of lotion, cream, ointment, dressing, bandage, rinse, soak, gel, spray, or other suitable forms, including certain devices. Additionally, the invention offers an efficient method of delivering the formulated composition containing one or two chelating agents or chelating agents alone or in combination with a metal ion salt using either a nanoparticle or other efficient delivery systems.

摘要翻译： 公开了包含螯合剂，金属离子盐，胶凝剂或缓冲剂，抗微生物剂，抗菌膜剂和用于预防和治疗伤口感染和涉及细菌生物膜的食源性疾病的pH调节剂或缓冲剂的组合物。 组合物的抗感染性质包括减少或杀死在多微生物生物膜中发生的厌氧/需氧/兼性革兰氏阴性和革兰氏阳性伤口感染相关细菌。 组合物可以是洗剂，霜剂，软膏，敷料，绷带，漂洗，浸泡，凝胶，喷雾或其它适合的形式，包括某些装置。 另外，本发明提供了一种使用纳米颗粒或其它有效递送系统递送含有一种或两种螯合剂或螯合剂的配制组合物或与金属离子盐组合的有效方法。

公开(公告)号：EP2162004A4

公开(公告)日：2013-01-16

申请号：EP08733701

申请日：2008-03-28

申请人： KANE BIOTECH INC

发明人： MADHYASTHA SRINIVASA ,  GAWANDE PURUSHOTTAM ,  LOVETRI KAREN

IPC分类号： A01N63/02 ,  A01N25/10 ,  A01N47/44 ,  A01P1/00 ,  A61K8/43 ,  A61K8/64 ,  A61L2/16 ,  A61L15/20 ,  A61L15/32 ,  A61Q11/00 ,  C09D5/14

CPC分类号： A61K31/155 ,  A01N47/44 ,  A61K38/1703 ,  A61L2/18 ,  A61L12/141 ,  A61L12/145 ,  A61L27/34 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/206 ,  A61L2300/252 ,  A61L2300/404 ,  A61L2300/42 ,  A01N37/46 ,  A01N61/00 ,  A01N63/00 ,  A01N2300/00 ,  C08L89/00 ,  A61K2300/00

公开(公告)号：EP2773369A4

公开(公告)日：2015-09-23

申请号：EP12844749

申请日：2012-06-27

申请人： KANE BIOTECH INC

发明人： LOVETRI KAREN ,  MADHYASTHA SRINIVASA ,  YAKANDAWALA NANDADEVA ,  GAWANDE PURUSHOTTAM V ,  FROEHLICH GORD

IPC分类号： A61K38/40 ,  A61K31/194 ,  A61K31/198 ,  A61K47/48 ,  A61P1/02 ,  A61P31/04 ,  C07K14/79

CPC分类号： A61K38/40 ,  A61K8/365 ,  A61K8/44 ,  A61K8/64 ,  A61K9/0063 ,  A61K9/127 ,  A61K9/5153 ,  A61K31/194 ,  A61K31/198 ,  A61K31/315 ,  A61K45/06 ,  A61K47/60 ,  A61K2800/51 ,  A61Q11/00 ,  A61Q17/005 ,  A61K2300/00

摘要： Compositions comprising iron-sequestering glycoproteins, chelating agents, stabilizing agents, binding agents, surfactants, fluorides, antimicrobials and a pH adjuster or buffer for the prevention and treatment of oral cavity diseases caused by dental plaque/biofilm, such as dental caries, gingivitis and periodontitis, through anti-infective properties are disclosed. The anti-infective properties of a composition include reduction or killing of anaerobic/aerobic/facultative gram-negative and gram-positive oral bacteria occurring in polymicrobial dental biofilms. The composition may be in the form of wash, rinse, soak, paste, gel, spray, or other suitable form. Additionally, the invention offers an efficient method of delivering the formulated composition containing a PEGylated or fluorinated iron-sequestering glycoprotein and one or two chelating agents or chelating agents alone using either a liposomal or a nanoparticle delivery system.

公开(公告)号：EP2389071A4

公开(公告)日：2012-08-08

申请号：EP10733164

申请日：2010-01-22

申请人： KANE BIOTECH INC

发明人： GAWANDE PURUSHOTTAM ,  MADHYASTHA SRINIVASA ,  LOVETRI KAREN ,  YAKANDAWALA NANDADEVA ,  FROEHLICH GORD

IPC分类号： A01N63/02 ,  A01N33/12 ,  A01N43/54 ,  A01N47/44 ,  A01N59/12 ,  A01N59/16 ,  A01P1/00 ,  A01P3/00 ,  A61K31/09 ,  A61K31/155 ,  A61K31/513 ,  A61K33/18 ,  A61K33/38 ,  A61K38/10 ,  A61K38/16 ,  A61K38/17 ,  A61L2/16 ,  A61P31/02

CPC分类号： A61K31/14 ,  A01N59/12 ,  A01N59/16 ,  A01N63/02 ,  A61K8/20 ,  A61K8/416 ,  A61K8/43 ,  A61K8/4953 ,  A61K8/64 ,  A61K31/09 ,  A61K31/155 ,  A61K31/513 ,  A61K31/635 ,  A61K33/38 ,  A61K45/06 ,  A61L12/088 ,  A61Q17/005 ,  A01N33/12 ,  A01N25/34 ,  A01N43/54 ,  A01N47/44 ,  A01N2300/00 ,  A61K2300/00

摘要： The present invention provides novel compositions comprising: (a) protamine sulfate and (b) benzalkonium chloride or a silver containing particle; or (a) sodium metaperiodate and (b) 5-fluorouracil or chlorhexidine and uses thereof for the preparation of devices, and in particular medical devices, susceptible to colonization by biofilm forming bacteria.

公开(公告)号：EP1833844A4

公开(公告)日：2009-05-13

申请号：EP05814632

申请日：2005-12-06

申请人： KANE BIOTECH INC

发明人： HUANG YI-CHEN CATHY ,  LEVESQUE CELINE ,  CVITKOVITCH DENNIS G ,  MADHYASTHA SRINIVASA

IPC分类号： C07K14/315 ,  A61K31/7088 ,  A61K38/10 ,  A61K38/16 ,  A61K39/395 ,  A61K48/00 ,  A61P31/04 ,  C07K7/08 ,  C12P21/02

CPC分类号： C07K14/315 ,  A61K38/00