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1.发明授权MODIFIED CARBONYL REDUCTASE, GENE THEREOF, AND METHOD OF PRODUCING OPTICALLY ACTIVE ALCOHOLS USING THESE 有权修饰的羰基还原酶，其基因和使用这些生产光学活性醇的方法
公开(公告)号：EP2562253B1
公开(公告)日：2017-08-02
申请号：EP11771784.3
申请日：2011-01-28
IPC分类号： C12N1/21 , C12N5/10 , C12P7/02 , C07D333/16 , C07D333/20 , C07D453/02 , C12N9/04 , C12P17/12 , C12P17/00
CPC分类号： C07D217/02 , C07D333/16 , C07D333/20 , C07D333/22 , C07D453/02 , C12N9/0006 , C12P7/02 , C12P17/00 , C12P17/12 , C12Y101/011
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2.发明公开PROCESS FOR PRODUCTION OF (R)-3-QUINUCLIDINOL 审中-公开VERFAHREN ZUR HERSTELLUNG VON（R）-3-CHINUCLIDINOL
公开(公告)号：EP2423320A1
公开(公告)日：2012-02-29
申请号：EP10767119.0
申请日：2010-04-22
CPC分类号： C12P17/182 , C12N9/0004 , C12P41/002
摘要： Provided is an efficient and industrial method for producing (R)-3-quinuclidinol which is a compound useful as an intermediate for the production of pharmaceuticals. The method for producing (R)-3-quinuclidinol includes reducing 3-quinuclidinone or a salt thereof in the presence of a polypeptide derived from bacteria of the genus Burkholderia or a recombinant organism capable of producing the polypeptide.
摘要翻译： 提供了一种生产（R）-3-奎宁环醇的有效和工业方法，其是可用作制备药物的中间体的化合物。 生产（R）-3-奎宁环醇的方法包括在衍生自伯克霍尔德氏菌属细菌的多肽或能够产生多肽的重组生物的存在下还原3-奎宁环素或其盐。
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3.发明公开MODIFIED CARBONYL REDUCTASE, GENE THEREOF, AND METHOD OF PRODUCING OPTICALLY ACTIVE ALCOHOLS USING THESE 有权变形碳水化合物，GEN DARAUS SOWIE VERFAHREN ZUR HERSTELLUNG OPTISCH AKTIVER ALKOHOLE DAMIT
公开(公告)号：EP2562253A1
公开(公告)日：2013-02-27
申请号：EP11771784.3
申请日：2011-01-28
IPC分类号： C12N15/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N15/09 , C12P7/02 , C07D333/16 , C07D333/20 , C07D453/02
CPC分类号： C07D217/02 , C07D333/16 , C07D333/20 , C07D333/22 , C07D453/02 , C12N9/0006 , C12P7/02 , C12P17/00 , C12P17/12 , C12Y101/011
摘要： Objects of the invention are to provide modified carbonyl reductases having improved reactivity in the presence of halogen atoms in comparison with a wild-type enzyme, as well as a method for efficiently manufacturing an optically active alcohol using these enzymes. Modified carbonyl reductases having improved reactivity in the presence of halogen atoms in comparison with the wild type were isolated from a library of modified carbonyl reductases prepared by introducing random mutations into the wild-type enzyme gene. There are also provided enzymes as well as DNA encoding the enzymes, transformants producing the enzymes, and a method of efficiently manufacturing an optically active alcohol using these.
摘要翻译： 本发明的目的是提供与野生型酶相比在卤素原子存在下具有改善的反应性的改性羰基还原酶，以及使用这些酶有效制备光学活性醇的方法。 与野生型相比，在卤素原子存在下具有改善的反应性的改性羰基还原酶从通过将随机突变引入野生型酶基因而制备的修饰的羰基还原酶文库中分离。 还提供酶以及编码酶的DNA，产生酶的转化体和使用这些酶有效制造光学活性醇的方法。
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4.发明授权NOVEL AMINOTRANSFERASE AND GENE ENCODING SAME, AND USE OF THE AMINOTRANSFERASE AND THE GENE 有权新的氨基转移酶和编码基因以及氨基转移酶和基因的用途
公开(公告)号：EP2623593B1
公开(公告)日：2017-07-12
申请号：EP11829175.6
申请日：2011-09-28
申请人： Kaneka Corporation
发明人： NAGASAWA Toru , YOSHIDA Toyokazu , ISHIDA Kouichi , ITO Noriyuki , KAWANO Shigeru , YASOHARA Yoshihiko
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12P13/00 , C12P41/00 , C12P17/10
CPC分类号： C12N9/1096 , C12P17/10 , C12P41/006 , C12Y206/01 , Y02P20/52
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5.发明公开NOVEL AMINOTRANSFERASE AND GENE ENCODING SAME, AND USE OF THE AMINOTRANSFERASE AND THE GENE 有权新的和转氨酶基因编码和氨基转移酶和基因的使用
公开(公告)号：EP2623593A1
公开(公告)日：2013-08-07
申请号：EP11829175.6
申请日：2011-09-28
申请人： Kaneka Corporation
发明人： NAGASAWA Toru , YOSHIDA Toyokazu , ISHIDA Kouichi , ITO Noriyuki , KAWANO Shigeru , YASOHARA Yoshihiko
CPC分类号： C12N9/1096 , C12P17/10 , C12P41/006 , C12Y206/01 , Y02P20/52
摘要： A method for efficiently producing an optically active amino compound useful as an intermediate for pharmaceutical preparations, agricultural chemicals, or the like, from a ketone compound is provided. Specifically, a polypeptide having high resistance to a water-soluble organic solvent and novel transaminase activity for generating (S)-1-benzyl-3-pyrrolidinone with high optical purity of 93% or more, a gene encoding the same, and a transformant expressing the gene at a high level are also provided herein.
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6.发明公开METHOD FOR PRODUCING OXIDIZED -GLUTAMYLCYSTEINE AND OXIDIZED GLUTATHIONE 审中-公开生产氧化型谷氨酰半胱氨酸和氧化谷胱甘肽的方法
公开(公告)号：EP3165610A1
公开(公告)日：2017-05-10
申请号：EP15815143.1
申请日：2015-07-02
申请人： Kaneka Corporation
摘要： The technical problem to be solved by the present invention is to provide a method for producing oxidized glutathione, GSSG and a precursor thereof, i.e., oxidized γ-glutamylcysteine, by a simple process. As a means for solving the problem, the method for producing GSSG according to the present invention comprises step A' of reacting L-cystine and L-glutamic acid to produce oxidized γ-glutamylcysteine and step B' of reacting oxidized γ-glutamylcysteine and glycine to produce GSSG.
摘要翻译： 本发明要解决的技术问题是提供一种通过简单的方法生产氧化型谷胱甘肽GSSG及其前体即氧化型γ-谷氨酰半胱氨酸的方法。 作为解决该问题的手段，本发明的GSSG的制造方法包括使L-胱氨酸和L-谷氨酸反应生成氧化型γ-谷氨酰半胱氨酸的工序A'，使氧化型γ-谷氨酰半胱氨酸和甘氨酸反应的工序B' 生产GSSG。
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7.发明授权
公开(公告)号：EP2623595B1
公开(公告)日：2016-11-02
申请号：EP11829206.9
申请日：2011-09-28
申请人： Kaneka Corporation
发明人： ITO Noriyuki , NISHI Akiko , KAWANO Shigeru , YASOHARA Yoshihiko
CPC分类号： C12N9/1096 , C12P17/10 , C12P41/006 , C12Y206/01 , Y02P20/52
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8.发明公开
公开(公告)号：EP2623595A1
公开(公告)日：2013-08-07
申请号：EP11829206.9
申请日：2011-09-28
申请人： Kaneka Corporation
发明人： ITO Noriyuki , NISHI Akiko , KAWANO Shigeru , YASOHARA Yoshihiko
CPC分类号： C12N9/1096 , C12P17/10 , C12P41/006 , C12Y206/01 , Y02P20/52
摘要： A method for inexpensively and efficiently producing an optically active amino compound useful as an intermediate for pharmaceutical preparations, agricultural chemicals, or the like, from a ketone compound is provided. Specifically, a polypeptide exhibiting higher activity for glutamic acid as an amino donor than that for L-alanine, and, having novel transaminase activity for generating (S)-1-benzyl-3-pyrrolidinone with high optical purity of 93% or more, a gene encoding the same, and a transformant expressing the gene at a high level are also provided herein.
摘要翻译： 本发明提供一种廉价且高效地制造在中间为药物制剂，农业化学品，或类似物作为有用的光学活性氨基化合物的，从酮化合物的方法。 具体而言，多肽参展谷氨酸更高的活性在氨基供体比用于L-丙氨酸，并且，具有用于产生（S）-1-苄基-3-吡咯烷酮以93％以上的高光学纯度新颖转氨酶活性， 编码基因是相同的，并因此被设置在以高水平表达该基因的转化体。
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