公开(公告)号：EP1395610A2

公开(公告)日：2004-03-10

申请号：EP02733478.8

申请日：2002-06-11

申请人： KIRIN BEER KABUSHIKI KAISHA

发明人： NISHIKAWA, Mitsuo,c/o Kirin Beer K. K. ,  DRMANAC, Radoje T. ,  LABAT, Ivan ,  LEE, Juhi ,  TANG, Y. Tom ,  STACHE-CRAIN, Birgit

IPC分类号： C07K14/475 ,  C12N15/12 ,  C12N5/06 ,  A61K38/00 ,  C07K16/22

CPC分类号： C12N5/0647 ,  A61K38/00 ,  C07K14/475

摘要： A gene encoding a polypeptide having an activity to support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is isolated by comparing expressed genes between cells which support proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells and cells which do not support the proliferation or survival. Proliferation or survival of hematopoietic stem cells or hematopoietic progenitor cells is supported by using stromal cells in which the isolated gene is expressed or a gene product of the isolated gene.

公开(公告)号：EP1248848B1

公开(公告)日：2007-02-28

申请号：EP00990346.9

申请日：2000-12-23

申请人： KIRIN BEER KABUSHIKI KAISHA

发明人： LABAT, Ivan ,  TANG, Y., Tom ,  DRMANAC, Radoje, T. ,  LIU, Chenghua ,  LEE, Juhi ,  MIZE, Nancy, K. ,  CHILDS, John ,  CHAO, Cheng-Chi

IPC分类号： C07K14/705 ,  C07K14/475 ,  C07K16/28 ,  C12N5/10 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566 ,  A61K38/17 ,  A61K31/713 ,  A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/475

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

公开(公告)号：EP1268543A2

公开(公告)日：2003-01-02

申请号：EP01932523.2

申请日：2001-04-05

申请人： KIRIN BEER KABUSHIKI KAISHA

发明人： TANG, Tom, Y. ,  LABAT, Ivan ,  CHAO , Cheng-Chi ,  MIZE ,Nancy , K. ,  NISHIKAWA ,Mitsuo ,  DRMANAC, Radoje, T.

IPC分类号： C07K14/475 ,  C12N15/12 ,  C12N5/10 ,  A61K38/18 ,  C07K16/22 ,  C12Q1/68 ,  G01N33/53 ,  A61K48/00 ,  C12N15/22

CPC分类号： C07K14/475 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695, from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

公开(公告)号：EP1248848A1

公开(公告)日：2002-10-16

申请号：EP00990346.9

申请日：2000-12-23

申请人： HYSEQ, INC. ,  KIRIN BEER KABUSHIKI KAISHA

发明人： LABAT, Ivan ,  TANG, Y., Tom ,  DRMANAC, Radoje, T. ,  LIU, Chenghua ,  LEE, Juhi ,  MIZE, Nancy, K. ,  CHILDS, John ,  CHAO, Cheng-Chi

IPC分类号： C12N15/63 ,  C12N15/85 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/47 ,  G01N33/53

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/475

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.