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    METHOD FOR PRODUCING 2-ISOPROPENYL-5-METHYL-4-HEXEN-1-YL 3-METHYL-2-BUTENOATE
    2.
    发明公开
    METHOD FOR PRODUCING 2-ISOPROPENYL-5-METHYL-4-HEXEN-1-YL 3-METHYL-2-BUTENOATE 有权
    VERFAHREN ZUR HERSTELLUNG VON 3-甲基-2-丁烯基-2-异丙基-5-甲基-4-己烯-1-基

    公开(公告)号：EP1867625A4

    公开(公告)日：2009-08-12

    申请号：EP06730408

    申请日：2006-03-29

    申请人： KURARAY CO

    发明人： UJITA KATSUJI ,  SATO JUNKO ,  FUKUMOTO TAKASHI

    IPC分类号： C07C67/10 ,  C07C69/533 ,  C07C303/28 ,  C07C309/66

    CPC分类号： C07C309/66 ,  C07C67/10 ,  C07C303/28 ,  C07C69/533 ,  C07C309/73

    摘要： Disclosed is a method for commercially advantageously producing 2-isopropenyl-5-methyl-4-hexen-1-yl 3-methyl-2-butenoate with high yield. Specifically disclosed is a method for producing 2-isopropenyl-5-methyl-4-hexen-1-yl 3-methyl-2-butenoate represented by the formula (IV) below which is characterized in that a sulfonate compound represented by the general formula (III) below is obtained by reacting 2-isopropenyl-5-methyl-4-hexen-1-ol with an organic sulfonyl halide in the presence of a basic substance, and then the thus-obtained sulfonate compound is reacted with a senecioic acid in the presence of a basic substance. (In the formula, R represents a hydrocarbon group.)

    摘要翻译： 公开了以高收率商业上有利地生产3-异丙烯基-5-甲基-4-己烯-1-基3-甲基-2-丁烯酸酯的方法。 具体而言，公开了由下述式（IV）表示的2-异丙烯基-5-甲基-4-丁烯酸-3-甲基-2-丁烯酸酯的制造方法，其特征在于，将通式 （III）通过在碱性物质存在下使2-异丙烯基-5-甲基-4-己烯-1-醇与有机磺酰卤反应而获得，然后将由此得到的磺酸酯化合物与异戊烯酸 在碱性物质存在下。 （式中，R表示烃基。）

    PROCESS FOR PRODUCING (5 ALPHA, 7 ALPHA)-3-SPIRO-2'-(1',3'-DIOXOLAN)-24-OXOCHOLEST-22-EN-7-YL BENZOATE
    6.
    发明公开
    PROCESS FOR PRODUCING (5 ALPHA, 7 ALPHA)-3-SPIRO-2'-(1',3'-DIOXOLAN)-24-OXOCHOLEST-22-EN-7-YL BENZOATE 审中-公开
    VERFAHREN ZUR HERSTELLUNG VONBENZOESÄURE-（5'，7'） - 3-SPIRO-2' - （1'，3'-DIOXILAN）-24-OXOCHOLEST-22-EN-7-YLESTER

    公开(公告)号：EP1837343A4

    公开(公告)日：2009-07-29

    申请号：EP05814172

    申请日：2005-12-07

    申请人： KURARAY CO

    发明人： KOYAKUMARU KENICHI ,  UJITA KATSUJI

    IPC分类号： C07J21/00

    CPC分类号： C07J21/00

    摘要： A process for producing (5a,7a)-3-spiro-2'-(1',3'-dioxolan)-24-oxocholest-22-en-7-yl benzoate (unsaturated ketone (I)), which is represented by the formula (I), (I) characterized by dissolving in methanol a crude reaction product which contains the unsaturated ketone (I) and has been obtained in a reaction step, the amount by mass of the methanol being 1.5-3 times the amount by mass of the unsaturated ketone (I) contained, to obtain a solution, adding the solution to water, the amount by mass of the water being 5-30 times the amount by mass of the unsaturated ketone (I) contained, to thereby obtain a suspension containing the unsaturated ketone (I) which has been solidified, separating the solid from the suspension, and drying the solid obtained. The unsaturated ketone (I) obtained is useful as an intermediate for squalamine, which has potent antibacterial activity and anticancer activity.

    摘要翻译： 生产（5a，7a）-3-螺-2' - （1'，3'-二氧戊环）-24-氧代胆甾-22-烯-7-基苯甲酸酯（不饱和酮（Ⅰ））的方法， （I）中，式（I）的特征在于，将在反应工序中得到的含有不饱和酮（I）的粗反应产物溶解在甲醇中，甲醇的质量为1.5〜3倍量 （I）的不饱和酮（I）的水溶液，将该溶液添加到水中，使水的质量为所含的不饱和酮（I）的质量的5〜30倍量，由此得到 含有已经固化的不饱和酮（I）的悬浮液，从悬浮液中分离固体，并干燥所得固体。 获得的不饱和酮（I）可用作角鲨胺的中间体，其具有有效的抗菌活性和抗癌活性。

    PROCESSES FOR PREPARATION OF CYCLOPROPYLETHANOL, CYCLO-PROPYLACETONITRILE AND INTERMEDIATES OF BOTH
    7.
    发明公开
    PROCESSES FOR PREPARATION OF CYCLOPROPYLETHANOL, CYCLO-PROPYLACETONITRILE AND INTERMEDIATES OF BOTH 审中-公开
    过程对于这两个连接产生与环丙基CYLCOPROPYLACETONITRIL和中间产品

    公开(公告)号：EP1445248A4

    公开(公告)日：2006-03-22

    申请号：EP02779965

    申请日：2002-10-31

    申请人： KURARAY CO

    发明人： UJITA KATSUJI

    IPC分类号： C07C29/14 ,  C07C45/58 ,  C07C249/08 ,  C07C251/38 ,  C07C253/00 ,  C07C255/31 ,  C07C31/133 ,  C07C47/11

    CPC分类号： C07C29/14 ,  C07C45/58 ,  C07C249/08 ,  C07C251/38 ,  C07C253/00 ,  C07C255/31 ,  C07C2601/02 ,  C07C47/11 ,  C07C31/1333

    摘要： A process for preparation of cyclopropylethanol which comprises subjecting a 3-cyclopropyl-2,3-epoxypropionic ester to solvolysis, treating the obtained product with an acid to form cyclopropylacetaldehyde, and reducing this aldehyde; and a process for preparation of cyclopropylacetonitrile which comprises reacting cyclopropylacetaldehyde obtained in the above process with hydroxylamine or a salt thereof to form cyclopropaneacetaldehyde oxime and reacting this oxime with acetic anhydride. According to the present invention, cyclopropylethanol or cyclopropylacetonitrile can be industrially advantageously prepared at a low cost.

    摘要翻译： 一种制备环丙基的方法，该方法包括使3-环丙基-2,3-环氧丙酸酯溶剂分解，用酸处理溶剂分解的产物，以获得至cyclopropylacetaldehyde，降低所获得的cyclopropylacetaldehyde; 和用于制备环丙基乙腈的，该方法包括使3-环丙基-2,3-环氧丙酸酯在碱的存在下溶剂分解，用酸处理溶剂分解的产物的方法，以获得到cyclopropylacetaldehyde，该反应得到cyclopropylacetaldehyde与 羟胺或其盐以获得cyclopropaneacetaldehyde肟，和与乙酸酐反应而获得cyclopropaneacetaldehyde肟。 。根据本发明，环丙基和环丙基乙腈可以以低的成本和工业上有利地制备。