公开(公告)号：EP1995237A4

公开(公告)日：2011-07-06

申请号：EP07707942

申请日：2007-02-02

申请人： KYORIN SEIYAKU KK

发明人： ASAHINA YOSHIKAZU ,  FUKUDA YASUMICHI ,  SHIGA FUTOSHI

IPC分类号： C07D207/16

CPC分类号： C07D207/16

公开(公告)号：EP1156047A4

公开(公告)日：2002-05-15

申请号：EP00905326

申请日：2000-02-25

申请人： KYORIN SEIYAKU KK

发明人： TAKANO YASUO ,  SHIGA FUTOSHI ,  ANRAKU TSUYOSHI ,  FUKUCHI KAZUNORI

IPC分类号： C07D403/04 ,  A61K31/498 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00 ,  C07D403/06

CPC分类号： A61K31/498

摘要： 6-Substituted-7- heteroquinoxaline carboxylic acid derivatives represented by general formula (1) and addition salts thereof, exhibiting antagonism against excitatory amino acid receptors, particularly AMPA receptor; and processes for the preparation of both (1) wherein A is a single bond or methylene (CH2); Y is nitrogen or =CH-; V is a single bond or methylene (CH2); T is hydroxyl, amino, lower alkoxycarbonyl, carboxyl, formyl, or the like; Q is halogeno, lower alkyl, or lower alkoxy; and R is hydroxyl, lower alkoxy, or the like.

公开(公告)号：EP2332908A4

公开(公告)日：2012-02-29

申请号：EP09814568

申请日：2009-09-15

申请人： KYORIN SEIYAKU KK

发明人： SHIGA FUTOSHI

IPC分类号： C07D207/16

CPC分类号： C07D207/16 ,  C07B63/02

公开(公告)号：EP1544194A4

公开(公告)日：2009-01-21

申请号：EP03765364

申请日：2003-07-23

申请人： KYORIN SEIYAKU KK

发明人： SHIGA FUTOSHI ,  KANDA TAKAHIRO ,  KIMURA TETSUYA ,  TAKANO YASUO ,  ISHIYAMA JUNICHI ,  KAWAI TOMOYUKI ,  ANRAKU TSUYOSHI ,  ISHIKAWA KUMI

IPC分类号： A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P17/02 ,  A61P19/02 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  A61P43/00 ,  C07D217/24 ,  C07D401/10 ,  C07D409/04 ,  C07D401/12

CPC分类号： C07D401/10 ,  A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/5377 ,  C07D217/24 ,  C07D409/04

摘要： A 4-(substituted aryl)-5-hydroxyisoquinolinone derivative having excellent poly(ADP-ribose) polymerase inhibitory activity; and a pharmacologically acceptable addition salt thereof. The 4-(substituted aryl)-5-hydroxyisoquinolinone derivative is represented by the general formula (1).

摘要翻译： 具有优异的聚（ADP-核糖）聚合酶抑制活性的4-（取代的芳基）-5-羟基异喹啉酮衍生物; 及其药理学上可接受的加成盐。 4-（取代的芳基）-5-羟基异喹啉酮衍生物由通式（1）表示。

公开(公告)号：EP1020453A4

公开(公告)日：2000-11-08

申请号：EP98940594

申请日：1998-08-28

申请人： KYORIN SEIYAKU KK

发明人： TAKANO YASUO ,  SHIGA FUTOSHI ,  TAKADOI MASANORI ,  UCHIKI HIDEHARU ,  ASANO JUN ,  ANRAKU TSUYOSHI ,  FUKUCHI KAZUNORI ,  UDA JUNICHIRO ,  ANDO NAOKI

IPC分类号： C07D241/44 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D521/00 ,  A61K31/495 ,  A61K31/505 ,  A61K31/535 ,  C07D403/06

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D241/44 ,  C07D249/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

摘要： Excitatory amino acid receptors comprising as the active ingredient 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives or addition salts thereof, particularly compounds exhibiting antagonism against AMPA receptors; and processes for the preparation of both. The disubstituted quinoxalinecarboxylic acid derivatives are represented by formula (1), wherein Q is halogeno, optionally halogenated lower alkyl, Ar-P- (wherein Ar is phenyl optionally substituted with one or more substituting groups, or naphthyl; and P is lower alkylene, lower alkenylene, lower alkynylene, oxygen or sulfur) or L-A-; R is nitro, trifluoromethyl, optionally substituted amino or a group of general formula (7), R1 is aralkyl, phenyl, naphthyl, a 5- or 6-membered heterocycle or a fused ring thereof (which may have one or more substituting groups on the aromatic ring or the heterocycle), hydrogen, optionally halogenated lower alkyl or cycloalkyl; and R2 is hydroxyl, lower alkoxy or a group of general formula (6).