利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.011 秒)

    BICYCLOESTER DERIVATIVE
    4.
    发明公开
    BICYCLOESTER DERIVATIVE 有权
    BICYCLOESTERDERIVAT

    公开(公告)号：EP1712547A4

    公开(公告)日：2007-09-26

    申请号：EP05704327

    申请日：2005-02-01

    申请人： KYORIN SEIYAKU KK

    发明人： FUKUDA YASUMICHI ,  ASAHINA YOSHIKAZU ,  OHATA KOHEI ,  YOKOTA KAZUYA ,  MURAKAMI KOJI ,  MATSUI TOSHIYUKI

    IPC分类号： C07D207/16 ,  A61K31/40 ,  A61K31/4025 ,  A61P3/10 ,  A61P43/00 ,  C07D405/12

    CPC分类号： C07D405/12 ,  C07D207/16 ,  Y02P20/55

    摘要： [PROBLEMS] To provide a novel bicycloester derivative having excellent DPP-IV inhibiting activity or a pharmacologically acceptable salt thereof. [MEANS FOR SOLVING PROBLEMS] There is provided a novel bicycloester derivative of the general formula: (1) or a pharmacologically acceptable salt thereof (for example, (2S,4S)-1-[[N-(4-ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl]-4-fluoropyrrolidine-2-carbonitrile).

    摘要翻译： [问题]提供具有优异的DPP-IV抑制活性的新型双环酯衍生物或其药理学上可接受的盐。 （1）或其药理学上可接受的盐（例如，（2S，4S）-1 - [[N-（4-乙氧基羰基二环[2.2.1]辛烷基）]的双环酯衍生物。 2]辛-1-基）氨基]乙酰基] -4-氟吡咯烷-2-腈）。

    7-(4-SUBSTITUTED 3- CYCLOPROPYLAMINOMETHYL-1- PYRROLIDINYL) Q UINOLONECARBOXYLIC ACID DERIVATIVE
    9.
    发明公开
    7-(4-SUBSTITUTED 3- CYCLOPROPYLAMINOMETHYL-1- PYRROLIDINYL) Q UINOLONECARBOXYLIC ACID DERIVATIVE 有权
    7-（4-取代基3-环丙基氨基磺酰基-1-吡咯烷基）中国化学物质

    公开(公告)号：EP1666477A4

    公开(公告)日：2008-10-22

    申请号：EP04787732

    申请日：2004-09-08

    申请人： KYORIN SEIYAKU KK

    发明人： ASAHINA YOSHIKAZU ,  TAKEI MASAYA

    IPC分类号： C07D401/04 ,  A61K31/4709 ,  A61P31/04 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D401/04

    摘要： [PROBLEMS] To provide a novel quinolonecarboxylic acid compound which is safe, has potent antibacterial activity, and is effective against resistant bacteria which are less controlled by conventional antibacterials. [MEANS FOR SOLVING PROBLEMS] It is a 7-(4-substituted 3-cyclopropylaminomethylpyrrolidinyl)quinolonecarboxylic acid derivative represented by the general formula (I)(typical example: 1-cyclopropyl-7-[(3S,4S)-3-cyclopropyl­aminomethyl-4-fluoro-1-pyrrolidinyl]-6-fluoro-1,4-dihydro­8-methoxy-4-oxo-3-quinolinecarboxylic acid). The derivative has potent antibacterial activity against gram-positive bacteria, in particular, resistant bacteria such as MRSA, PRSP, and VRE, and is highly safe.