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公开(公告)号：EP2774912A4
公开(公告)日：2015-07-29
申请号：EP12846224
申请日：2012-11-02
发明人： KUBOYAMA TAKESHI , ERA TOMOHIRO , NAOI TOMOYUKI , YAGI NOBUHIRO
IPC分类号： C07C217/08 , A61K31/231 , A61K31/24 , A61K31/40 , A61P29/00 , A61P35/00 , C07C219/08 , C07C237/06 , C07C271/20 , C07D207/08 , C07D207/12 , C07D491/056 , C12N15/09
CPC分类号： C07C217/06 , A61K9/0019 , A61K9/1272 , C07C217/08 , C07C219/08 , C07C237/06 , C07C237/08 , C07C271/16 , C07D207/08 , C07D207/12 , C07D295/08 , C07D317/28 , C07D401/04 , C07D491/04 , C07D491/056 , C12N15/88
摘要： The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X 3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L 3 is a single bond, etc, R 3 is alkyl, etc, L 1 and L 2 are -O-, -CO-O- or -O-CO-), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.
摘要翻译： 本发明提供一种阳离子脂质，其允许将核酸容易地引入由式（I）表示的细胞中（其中：R 1和R 2相同或不同，烯基等，X 1和X 2 或组合在一起形成单键或亚烷基，X 3不存在或为烷基等，Y不存在或阴离子，a和b相同或不同，为0〜3，L 3 是单键等，R 3是烷基等，L 1和L 2是-O-，-CO-O-或-O-CO-），包含阳离子脂质和核酸的组合物，和 通过使用包含阳离子脂质和核酸的组合物等将核酸引入细胞的方法。
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公开(公告)号：EP2792368A4
公开(公告)日：2015-09-30
申请号：EP12858270
申请日：2012-12-12
发明人： KUBOYAMA TAKESHI , ERA TOMOHIRO , NAOI TOMOYUKI
IPC分类号： A61K47/18 , A61K9/127 , A61K9/51 , A61K31/713 , A61K38/00 , A61K47/22 , C07C211/21 , C07D207/12 , C12N15/88
CPC分类号： A61K47/22 , A61K9/5123 , A61K31/713 , A61K47/18 , C07C211/21 , C07D207/12 , C12N15/88
摘要： The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 3 is absent or is alkyl, etc, X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and Y 1 is absent or anion, L 1 is a single bond, etc, R 3 is alkyl, etc), and a cationic lipid represented by formula (II) (wherein: R 9 and R 5 are, the same or different, alkenyl, etc, and X 4 and X 5 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X 6 is absent or is alkyl, etc, Y 2 is absent or anion, a and b are, the same or different, 0 to 3, and L 9 is a single bond, etc, R 6 is alkyl, etc, L 2 and L 3 are -O-, -CO-O- or -O-CO-), and the like.
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公开(公告)号：EP2308880A4
公开(公告)日：2012-06-06
申请号：EP09773568
申请日：2009-07-03
IPC分类号： C07D491/044 , A61K31/4162 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P7/10 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08
CPC分类号： C07D491/044 , C07D491/14
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公开(公告)号：EP2871178A4
公开(公告)日：2016-05-11
申请号：EP13812898
申请日：2013-07-08
发明人： KUBOYAMA TAKESHI , ERA TOMOHIRO , NAOI TOMOYUKI , YAGI KAORI , HOSOE SHINTARO
IPC分类号： C07C271/12 , A61K31/7088 , A61K47/18 , A61K47/44 , A61K47/48 , A61K48/00 , A61P29/00 , A61P35/00 , C07C211/21 , C07C215/08 , C07C217/08 , C07C271/16 , C07D207/06 , C07D207/08 , C07D211/06 , C07D211/22 , C07D223/04 , C07D225/02 , C12N15/09 , C12N15/113
CPC分类号： A61K47/48046 , A61K31/7088 , A61K47/543 , A61K48/00 , C07C211/21 , C07C215/08 , C07C215/10 , C07C217/08 , C07C229/12 , C07C237/06 , C07C271/12 , C07C271/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D211/06 , C07D211/22 , C07D211/34 , C07D223/04 , C07D225/02 , C07D295/145 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要： Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein R 1 is alkenyl or the like, R 2 is alkenyl or the like, R 3 and R 9 are each alkyl, or are combined together to form alkylene, or R 3 and R 5 are combined together to form alkylene, R 5 is a hydrogen atom or the like, or is combined together with R 3 to form alkylene, X 1 is alkylene, and X 2 is a single bond or alkylene).
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公开(公告)号：EP2567952A4
公开(公告)日：2015-11-25
申请号：EP11775150
申请日：2011-04-28
发明人： KUBOYAMA TAKESHI , ERA TOMOHIRO , NAOI TOMOYUKI
IPC分类号： C07C217/28 , A61K9/127 , A61K47/18 , A61K47/22 , A61K48/00 , A61P29/00 , A61P35/00 , C07C217/08 , C07D207/08 , C07D207/12 , C07D295/088 , C07D317/28 , C07D491/056 , C12N15/88
CPC分类号： A61K47/44 , A61K9/1272 , C07C211/21 , C07C217/08 , C07C217/28 , C07D207/08 , C07D207/12 , C07D209/00 , C07D221/04 , C07D223/14 , C07D295/088 , C07D317/28 , C07D491/056 , C12N15/88
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公开(公告)号：EP2567951A4
公开(公告)日：2015-11-25
申请号：EP11775149
申请日：2011-04-28
发明人： KUBOYAMA TAKESHI , ERA TOMOHIRO , NAOI TOMOYUKI
IPC分类号： C07C217/28 , A61K9/00 , A61K9/127 , A61K47/16 , A61K48/00 , A61P29/00 , A61P35/00 , C07C219/08 , C07C219/20 , C07C233/18 , C07D207/08 , C07D207/12 , C12N15/113
CPC分类号： C07D401/04 , A61K9/0019 , A61K9/1272 , A61K47/16 , A61K47/18 , A61K47/186 , A61K47/22 , C07C217/08 , C07C217/28 , C07C217/40 , C07C219/06 , C07C219/08 , C07C237/06 , C07C237/22 , C07C271/22 , C07D207/08 , C07D207/12 , C07D211/58 , C07D491/056 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12N2310/321 , C12N2310/3521
摘要： The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X 3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L 3 is a single bond, etc, R 3 is alkyl, etc, L 1 and L 2 are -0-, -CO-O- or -O-CO-), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.
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7.发明公开LIPID NANOPARTICLES FOR DRUG DELIVERY SYSTEM CONTAINING CATIONIC LIPIDS 审中-公开LIPID-NANOPARTIKELFÜREIN ARZNEIMITTELVERABREICHUNGSSYSTEM MIT KATIONISCHEN LIPIDEN
公开(公告)号：EP2792367A4
公开(公告)日：2015-09-30
申请号：EP12857103
申请日：2012-12-12
发明人： KUBOYAMA TAKESHI , ERA TOMOHIRO , NAOI TOMOYUKI
IPC分类号： A61K47/18 , A61K9/00 , A61K9/127 , A61K9/51 , A61K31/7088 , A61K38/00 , C07C211/21 , C12N15/88
CPC分类号： A61K9/5123 , A61K9/0019 , A61K31/7088 , A61K31/712 , A61K31/713 , A61K47/18 , C07C211/21 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2320/32
摘要： The present invention provides a lipid nano-particles, which allow nucleic acids to be easily introduced into cells, comprising a cationic lipid represented by formula (I) (wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 3 is absent or is alkyl, etc, X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and Y 1 is absent or anion, L 1 is a single bond, etc, R 3 is alkyl, etc), and the like.
摘要翻译： 本发明提供一种脂质纳米颗粒，其允许将核酸容易地引入细胞，其包含由式（I）表示的阳离子脂质（其中：R 1和R 2相同或不同，烯基等） 并且X 3不存在或者是烷基等，X 1和X 2是氢原子，或者组合在一起形成单键或亚烷基，Y 1不存在或阴离子，L 1是单键等，R 3是烷基等）等。
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