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公开(公告)号：EP2319519A4
公开(公告)日：2013-01-09
申请号：EP09803053
申请日：2009-07-31
发明人： YAGI NOBUHIRO , ENOKIZONO JUNICHI
IPC分类号： A61K31/712 , A61K9/127 , A61K31/7105 , A61K31/713 , A61K47/10 , A61K47/18 , A61K47/24 , A61K47/28 , A61K47/34 , A61P29/00 , A61P35/00 , A61P43/00 , C12N15/113
CPC分类号： A61K31/7105 , A61K9/0019 , A61K9/1271 , A61K31/712 , A61K31/713 , C12N15/1135 , C12N2310/14 , Y10T436/143333
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公开(公告)号：EP2774912A4
公开(公告)日：2015-07-29
申请号：EP12846224
申请日：2012-11-02
发明人： KUBOYAMA TAKESHI , ERA TOMOHIRO , NAOI TOMOYUKI , YAGI NOBUHIRO
IPC分类号： C07C217/08 , A61K31/231 , A61K31/24 , A61K31/40 , A61P29/00 , A61P35/00 , C07C219/08 , C07C237/06 , C07C271/20 , C07D207/08 , C07D207/12 , C07D491/056 , C12N15/09
CPC分类号： C07C217/06 , A61K9/0019 , A61K9/1272 , C07C217/08 , C07C219/08 , C07C237/06 , C07C237/08 , C07C271/16 , C07D207/08 , C07D207/12 , C07D295/08 , C07D317/28 , C07D401/04 , C07D491/04 , C07D491/056 , C12N15/88
摘要： The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: R 1 and R 2 are, the same or different, alkenyl, etc, and X 1 and X 2 are hydrogen atoms, or are combined together to form a single bond or alkylene, and X 3 is absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and L 3 is a single bond, etc, R 3 is alkyl, etc, L 1 and L 2 are -O-, -CO-O- or -O-CO-), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.
摘要翻译： 本发明提供一种阳离子脂质，其允许将核酸容易地引入由式（I）表示的细胞中（其中：R 1和R 2相同或不同，烯基等，X 1和X 2 或组合在一起形成单键或亚烷基，X 3不存在或为烷基等，Y不存在或阴离子，a和b相同或不同，为0〜3，L 3 是单键等，R 3是烷基等，L 1和L 2是-O-，-CO-O-或-O-CO-），包含阳离子脂质和核酸的组合物，和 通过使用包含阳离子脂质和核酸的组合物等将核酸引入细胞的方法。
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3.发明公开METHOD FOR PRODUCING FINE PARTICLE SURFACE-MODIFIED WITH WATER-SOLUBLE SUBSTANCE 审中-公开一种用于生产细颗粒的水溶性物质表面改性
公开(公告)号：EP1842585A4
公开(公告)日：2013-05-29
申请号：EP06712509
申请日：2006-01-27
IPC分类号： B01J13/20 , A61K9/00 , A61K9/107 , A61K9/127 , A61K47/12 , A61K47/24 , A61K47/28 , A61K47/34 , A61K47/44 , B01J13/02
CPC分类号： A61K9/1271 , A61K9/0019 , A61K9/107 , B01J13/02
摘要： An object of the present invention is to provide a method of easily producing fine particles comprising a lipid, a fatty acid, or a derivative thereof, surface-modified with a water-soluble substance, etc. There are provided a method of producing a fine particles, surface-modified with a water-soluble substance, which contains the process of dispersing fine particles comprising a lipid, a fatty acid, or a derivative thereof, and dissolving or dispersing a surface modifier which is a lipid derivative, a fatty acid derivative, or an aliphatic hydrocarbon derivative of a water-soluble substance, in a liquid containing a polar organic solvent, and the like.
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公开(公告)号：EP1852178A4
公开(公告)日：2013-04-24
申请号：EP06712508
申请日：2006-01-27
发明人： YAGI NOBUHIRO , TOKUDA TAKUYA , NAKAKURA MASASHI , KATO YASUKI
IPC分类号： B01J13/04 , A61K9/10 , A61K9/127 , A61K31/7088 , A61K38/00 , A61K47/24 , A61K47/34 , A61K48/00
CPC分类号： A61K9/5123 , A61K9/1075 , A61K9/5192 , A61K31/7088 , B01J13/04 , Y10T428/2991
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5.发明公开COMPOSITION INHIBITING THE EXPRESSION OF TARGET GENE IN EYEBALL AND REMEDY FOR DISEASE IN EYEBALL 审中-公开组合物技术在一个眼球FOR眼球疾病靶点基因抑制和赔偿
公开(公告)号：EP1970078A4
公开(公告)日：2010-11-17
申请号：EP07706535
申请日：2007-01-10
发明人： YAGI NOBUHIRO , YAMAUCHI MASAHIRO , AOKI NOBORU , TAMAKI YASUHIRO , TAKAHASHI HIDENORI , IRIYAMA AYA , NAGAI RYOZO , MANABE ICHIRO
CPC分类号： A61K9/1272 , A61K9/0048 , A61K9/127 , A61K31/7105 , A61K48/0033 , A61K48/0041 , C12N15/111 , C12N2310/14 , C12N2320/32
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公开(公告)号：EP1842558A4
公开(公告)日：2010-04-07
申请号：EP05805115
申请日：2005-10-24
IPC分类号： A61K48/00 , A61K9/127 , A61K31/7105 , A61K47/24 , A61K47/44 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： C12N15/1135 , A61K9/127 , A61K31/7105 , C12N2310/14
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