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10 条记录 (耗时 0.026 秒)

    Alpha-1,3-fucosyltransferase
    3.
    发明授权
    Alpha-1,3-fucosyltransferase 失效
    α-1,3-岩藻糖基

    公开(公告)号：EP0643132B1

    公开(公告)日：2006-05-31

    申请号：EP94910547.2

    申请日：1994-03-28

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： SASAKI, Katsutoshi ,  KURATA, Kazumi ,  HANAI, Nobuo ,  NISHI, Tatsunari

    IPC分类号： C12N9/10

    CPC分类号： C12N9/1051

    摘要： A novel alpha -1,3-fucosyltransferase which is expressed by the gene cloned from animal cells; a cDNA coding for the transferase; a method of detecting alpha -1,3-fucosyltransferase using the cDNA and inhibiting the production of the transferase; a recombinant vector containing the cDNA integrated thereinto; a cell containing the vector; and processes for producing the above. The alpha -1,3-fucosyltransferase invented is useful for producing physiologically active sugar chains, such as sialylated Lewis X, and modifications thereof.

    NOVEL ANTIBODIES, DRUGS CONTAINING THESE ANTIBODIES AND METHODS FOR SCREENING COMPOUNDS BY USING THESE ANTIBODIES
    7.
    发明公开
    NOVEL ANTIBODIES, DRUGS CONTAINING THESE ANTIBODIES AND METHODS FOR SCREENING COMPOUNDS BY USING THESE ANTIBODIES 审中-公开
    新抗体药物含有它们的筛选化合物的方法，使用这种抗体

    公开(公告)号：EP1118622A1

    公开(公告)日：2001-07-25

    申请号：EP99969723.8

    申请日：1999-09-29

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： HANAI, Nobuo ,  FURUYA, Akiko

    IPC分类号： C07K16/40 ,  C12P21/08 ,  G01N33/53 ,  A61K39/395

    CPC分类号： G01N33/5091 ,  C07K16/40 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/573 ,  G01N2500/00

    摘要： The present invention provides antibodies which recognize a novel, membrane-type matrix metalloproteinase polypeptide [MT4-MMP(2)] that has, different from the hitherto reported MT4-MMP, physiological activity; prophylactic agents, diagnostic agents and therapeutic agents comprising the antibodies, for various diseases such as arthrosis deformans, rheumatoid arthritis, asthma, autoimmune diseases, or atopic dermatitis; and methods of screening for inhibitors and activators of MT4-MMP(2) using the antibodies.
    The second object of the present invention is to provide antibodies which recognize novel, human and mouse membrane-type matrix metalloproteinase MT5-MMP polypeptides having physiological activity; prophylactic agents, diagnostic agents and therapeutic agents comprising the antibodies, for various diseases such as arthrosis deformans, rheumatoid arthritis, asthma, autoimmune diseases, atopic dermatitis, brain disorders at the time of cerebral apoplexy, or Alzheimer's disease; and methods of screening for inhibitors and activators of MT5-MMP using the antibodies.

    摘要翻译： 本发明提供了识别的新的，膜型基质金属蛋白酶多肽AMT4-MMP（2）U没有，从迄今报导MT4-MMP，生理活性的不同抗体; 预防剂，诊断剂和治疗剂，其包括抗体，用于治疗各种疾病：如变形性关节病，类风湿性关节炎，哮喘，自身免疫性疾病，或特应性皮炎; 和筛选抑制剂和使用该抗体（2）MT4-MMP的活化剂的方法。 本发明的第二个目的是提供一种抗体识别具有生理活性的新的哪个，人和小鼠膜型基质金属蛋白酶MT5-MMP多肽; 预防剂，诊断剂和治疗剂，其包括抗体，用于治疗各种疾病：如变形性关节病，类风湿性关节炎，哮喘或，自身免疫性疾病，过敏性皮炎，在脑中风，或阿尔茨海默氏病的脑时间障碍; 和筛选使用该抗体MT5-MMP的抑制剂和活化剂的方法。

    MONOCLONAL ANTIBODY AGAINST HUMAN Mx PROTEIN MxA
    9.
    发明公开
    MONOCLONAL ANTIBODY AGAINST HUMAN Mx PROTEIN MxA 失效
    MONOKLONALERANTIKÖRPERGEGEN MxA DES MENSCHLICHEN Mx蛋白

    公开(公告)号：EP0725081A1

    公开(公告)日：1996-08-07

    申请号：EP95927989.4

    申请日：1995-08-08

    申请人： KYOWA HAKKO KOGYO CO., LTD. ,  KYOWA MEDEX CO., LTD.

    发明人： HANAI, Nobuo ,  NAGATA, Kyosuke ,  FURUYA, Akiko ,  KUSANO, Akira ,  TANIGUCHI, Noboru

    IPC分类号： C07K16/18 ,  C12P21/08 ,  C12N15/06 ,  C12N5/20

    CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4718

    摘要： This invention provides a monoclonal antibody which recognizes an epitope corresponding to amino acids 10 to 220, amino acids 221 to 297, or amino acids 469 to 662, counting from the N-terminus of a human Mx protein MxA, and specifically reacts with the human Mx protein by western blotting, immunoprecipitation or immunocyte staining, and a hybridoma which produces the antibody. The human Mx protein MxA monoclonal antibody of this invention can be used, for example, in the diagnosis of viral infection.

    摘要翻译： 本发明提供一种单克隆抗体，其识别对应于人Mx蛋白MxA的N末端计数的氨基酸10至220，氨基酸221至297或氨基酸469至662的表位，并与人类特异性反应 通过蛋白质印迹，免疫沉淀或免疫细胞染色的Mx蛋白和产生抗体的杂交瘤。 本发明的人Mx蛋白MxA单克隆抗体可用于例如病毒感染的诊断。

    $g(a)-1,3-FUCOSYLTRANSFERASE
    10.
    发明公开
    $g(a)-1,3-FUCOSYLTRANSFERASE 失效
    α-1,3-岩藻糖基

    公开(公告)号：EP0643132A1

    公开(公告)日：1995-03-15

    申请号：EP94910547.2

    申请日：1994-03-28

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： SASAKI, Katsutoshi ,  KURATA, Kazumi ,  HANAI, Nobuo ,  NISHI, Tatsunari

    IPC分类号： C12N9/10

    CPC分类号： C12N9/1051

    摘要： A novel α-1,3-fucosyltransferase which is expressed by the gene cloned from animal cells; a cDNA coding for the transferase; a method of detecting α-1,3-fucosyltransferase using the cDNA and inhibiting the production of the transferase; a recombinant vector containing the cDNA integrated thereinto; a cell containing the vector; and processes for producing the above. The α-1,3-fucosyltransferase invented is useful for producing physiologically active sugar chains, such as sialylated Lewis X, and modifications thereof.

    摘要翻译： 由动物细胞克隆的基因表达的新型α-1,3-岩藻糖基转移酶; 编码转移酶的cDNA; 使用cDNA检测α-1,3-岩藻糖基转移酶并抑制转移酶的产生的方法; 包含其中整合的cDNA的重组载体; 含有载体的细胞; 以及制造上述方法。 发明的α-1,3-岩藻糖基转移酶可用于生产生理活性糖链，例如唾液酸化的路易斯X及其修饰。