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14 条记录 (耗时 0.028 秒)

    NOVEL VECTOR
    5.
    发明公开
    NOVEL VECTOR 失效
    尼古拉维克

    公开(公告)号：EP0121569A1

    公开(公告)日：1984-10-17

    申请号：EP83902695.2

    申请日：1983-08-24

    申请人： KYOWA HAKKO KOGYO CO., LTD. ,  JURIDICAL FOUNDATION JAPANESE FOUNDATION FOR CANCER RESEARCH

    发明人： TANIGUCHI, Tadatsugu ,  SUGANO, Haruo ,  NISHI, Tatsunari ,  SATO, Moriyuki ,  ITO, Seiga

    IPC分类号： C12N15/00 ,  C07H21/04 ,  C12P19/34 ,  C12N1/20

    CPC分类号： C12N15/00 ,  C07K14/565 ,  C12N15/70

    摘要： A vector containing genetic information necessary for starting transcription and translation and a signal of starting translation (ATG or GTG), which is suitable for incorporating a peptide-coding DNA segment and effectively producing the peptide, a process for its preparation, and its utilization.

    摘要翻译： 载体含有启动子（P）; 将该序列中的一些结合位点（RBS）和翻译起始密码子（SC）和（新特征）作为限制酶（I）的识别位点。 用（I）切割后，该部位保持3'-重叠的末端。 县。 SC是ATG或GTG，（I）是SphI，EcoRV，KpHI或SacI。 P可以衍生自原核生物（特别是来自大肠杆菌的trp，lac或λ噬菌体或枯草芽孢杆菌启动子），或者整个P-RBS-SC序列衍生自真核生物。 同样新的是用这些载体或类似载体转化的微生物，外源基因插入其中。 载体不需要合成的DNA片段来调节RBS和SC之间的距离。 外源基因，特别编码干扰素或其衍生物，可插入限制位点。

    NOVEL DNA, NOVEL PROTEIN, AND NOVEL ANTIBODY
    7.
    发明公开
    NOVEL DNA, NOVEL PROTEIN, AND NOVEL ANTIBODY 失效
    NEUE DNA，NEUES蛋白质，NEUERANTIKÖRPER

    公开(公告)号：EP0949271A1

    公开(公告)日：1999-10-13

    申请号：EP97946126.6

    申请日：1997-12-05

    申请人： KYOWA HAKKO KOGYO CO., Ltd.

    发明人： YOSHISUE, Hajime ,  SAITO, Akiko ,  NAKAGAWA, Satoshi ,  KUGA, Tetsuro ,  SHINKAI, Akeo ,  KOIKE, Masamichi ,  NISHI, Tatsunari

    IPC分类号： C07K14/54 ,  C12N15/24 ,  C12N5/10 ,  C12N5/20 ,  C07K16/24 ,  G01N33/577 ,  G01N33/50 ,  A61K39/00 ,  A61K38/19 ,  C12Q1/68 ,  C12Q1/04

    CPC分类号： C07K14/523 ,  A61K38/00 ,  C07K16/24

    摘要： A novel protein capable of activating eosinophile cells; a DNA or oligonucleotides encoding this protein; a recombinant vector containing this DNA; a transformant containing this recombinant vector; a process for producing the above protein by using this transformant; a cell reacting specifically with the above protein; a cell membrane or a receptor binding specifically to the above protein; an agonist or an antagonist to the protein; an antibody binding specifically to the protein; and remedies or diagnostic methods with the use of the same for allergic inflammation, eosinophilic pneumonia, sudden eosinophilia, autoimmune disease, malignant tumor, or vermination.

    摘要翻译： 能够激活嗜酸性粒细胞的新型蛋白质; 编码该蛋白质的DNA或寡核苷酸; 含有该DNA的重组载体; 含有该重组载体的转化体; 通过使用该转化体生产上述蛋白质的方法; 与上述蛋白质特异性反应的细胞; 细胞膜或与上述蛋白质特异性结合的受体; 该蛋白质的激动剂或拮抗剂; 特异性结合蛋白质的抗体; 以及使用过敏性炎症，嗜酸粒细胞性肺炎，突发性嗜酸性粒细胞增多症，自身免疫性疾病，恶性肿瘤或萌发的补救措施或诊断方法。

    $g(a)-1,3-FUCOSYLTRANSFERASE
    9.
    发明公开
    $g(a)-1,3-FUCOSYLTRANSFERASE 失效
    α-1,3-岩藻糖基

    公开(公告)号：EP0643132A1

    公开(公告)日：1995-03-15

    申请号：EP94910547.2

    申请日：1994-03-28

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： SASAKI, Katsutoshi ,  KURATA, Kazumi ,  HANAI, Nobuo ,  NISHI, Tatsunari

    IPC分类号： C12N9/10

    CPC分类号： C12N9/1051

    摘要： A novel α-1,3-fucosyltransferase which is expressed by the gene cloned from animal cells; a cDNA coding for the transferase; a method of detecting α-1,3-fucosyltransferase using the cDNA and inhibiting the production of the transferase; a recombinant vector containing the cDNA integrated thereinto; a cell containing the vector; and processes for producing the above. The α-1,3-fucosyltransferase invented is useful for producing physiologically active sugar chains, such as sialylated Lewis X, and modifications thereof.

    摘要翻译： 由动物细胞克隆的基因表达的新型α-1,3-岩藻糖基转移酶; 编码转移酶的cDNA; 使用cDNA检测α-1,3-岩藻糖基转移酶并抑制转移酶的产生的方法; 包含其中整合的cDNA的重组载体; 含有载体的细胞; 以及制造上述方法。 发明的α-1,3-岩藻糖基转移酶可用于生产生理活性糖链，例如唾液酸化的路易斯X及其修饰。

    PROCESS FOR PREPARING 5'-GUANYLIC ACID
    10.
    发明授权
    PROCESS FOR PREPARING 5'-GUANYLIC ACID 失效
    制备5'-胍酸的方法

    公开(公告)号：EP0185092B1

    公开(公告)日：1992-10-07

    申请号：EP85901555.4

    申请日：1985-03-12

    申请人： KYOWA HAKKO KOGYO CO., LTD.

    发明人： FUJIO, Tatsuro ,  MARUYAMA, Akihiko ,  NISHI, Tatsunari ,  OZAKI, Akio ,  ITO, Seiga ,  OZAKI, Atsuko

    IPC分类号： C12P19/32 ,  C12N15/52

    CPC分类号： C12N9/93 ,  A61K39/00 ,  C07K14/57 ,  C12P19/32

    摘要： GMP can be prepared in a good yield by converting XMP, ammonia and/or L-glutamine in an aqueous solution using a culture product, cells or their treated product of E. coli having GMP synthetase activity and the ability of converting AMP to ATP in the presence of an energy source other than phosphorus oxides, in the presence of the energy source. GMP can also be prepared in a good yield by converting XMP, ammonia and/or L-glutamine to GMP in an aqueous medium in the presence of ATP using a culture product, cells or their treated product of transformant obtained by using a recombinant DNA of a DNA fragment containing GMP synthetase gene and a vector DNA fragment. The process of using transformant having ATP-reproducing ability is extremely advantageous.