公开(公告)号：EP1072683A1

公开(公告)日：2001-01-31

申请号：EP99913662.5

申请日：1999-04-14

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： MIYAKE, Koichiro, Kyowa Apartment C-3 ,  HASHIMOTO, Shinichi, LSP machida 1203 ,  MOTOYAMA, Hiroaki ,  OZAKI, Akio ,  SETO, Haruo ,  KUZUYAMA, Tomohisa ,  TAKAHASHI, Shunji, Greenhouse B 102

IPC分类号： C12N15/52 ,  C12P23/00 ,  C12N9/00 ,  C12N9/10 ,  A01N57/18 ,  C12Q1/25 ,  C12Q1/48

CPC分类号： C12N9/1085 ,  A01N63/02 ,  C12N9/0006 ,  C12N9/1022 ,  C12N15/52 ,  C12P7/66 ,  C12P23/00 ,  C12Q1/18 ,  C12Y202/01007 ,  G01N2430/20

摘要： The present invention provides a process for producing isoprenoid compounds or proteins encoded by DNA using DNA that contains one or more of the DNA encoding proteins having activity to improve efficiency in the biosynthesis of isoprenoid compounds effective in pharmaceuticals for cardiac diseases, osteoporosis, homeostasis, prevention of cancer, and immunopotentiation, health food and anti-fouling paint products against barnacles the DNA; the protein; and a method for screening a substance with antibiotic and weeding activities comprising screening a substance inhibiting enzymatic reaction on the non-mevalonate pathway.

摘要翻译： 本发明提供了使用含有一种或多种具有提高生物合成有效的心血管疾病，骨质疏松症，体内平衡，预防性药物的类异戊二烯化合物的生物合成能力的DNA编码蛋白质的DNA来生产类异戊二烯化合物或由DNA编码的蛋白质的方法 的癌症和免疫增强，保健食品和防污漆产品针对藤壶的DNA; 蛋白质; 以及用于筛选具有抗生素和除草活性的物质的方法，其包括在非甲羟戊酸途径上筛选抑制酶反应的物质。