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    NUCLEIC ACID DETECTION CASSETTE AND NUCLEIC ACID DETECTION APPARATUS
    1.
    发明公开
    NUCLEIC ACID DETECTION CASSETTE AND NUCLEIC ACID DETECTION APPARATUS 审中-公开
    NUKLEINSÄUREDETEKTIONSKASSETTEUNDNUKLEINSÄUREDETEKTIONSVORRICHTUNG

    公开(公告)号：EP1997888A1

    公开(公告)日：2008-12-03

    申请号：EP07739538.2

    申请日：2007-03-23

    申请人： Kabushiki Kaisha Toshiba

    发明人： HONGO, Sadato ,  OKADA, Jun ,  OOKI, Kenji ,  GEMMA, Nobuhiro

    IPC分类号： C12N15/09 ,  C12M1/00 ,  C12Q1/68 ,  G01N27/28 ,  G01N27/327 ,  G01N35/08 ,  G01N37/00

    CPC分类号： G01N35/1095 ,  G01N33/5308 ,  G01N33/54366

    摘要： A nucleic acid cassette includes a main body in which first and second channels are formed. A sample containing a target nucleic acid is input in a sample chamber of the second channel via an injection port. In the cassette, a detecting part is incorporated which includes a detection chamber communicated to the first and second channels and a nucleic detection unit. The first channel has a first reagent reservoir storing a first reagent stored and a second reagent reservoir storing a second reagent. The first and second reagents reservoirs are separated by a gaseous body in the channel. The sample and the first and second reagents are supplied to the detecting part due to an action of a pump part which is communicated to the first and second channels. Accordingly, it is possible to prevent a non-detection target nucleic monocle from being mixed and a nucleic acid sample from being leaked to the outside.

    摘要翻译： 核酸盒包括其中形成有第一和第二通道的主体。 含有靶核酸的样品通过注射口输入到第二通道的样品室中。 在盒中，包括检测部，其包括与第一和第二通道连通的检测室和核酸检测单元。 第一通道具有存储第一试剂储存器的第一试剂储存器和存储第二试剂的第二试剂储存器。 第一和第二试剂容器在通道中被气体体分开。 由于与第一和第二通道连通的泵部的动作，将样品和第一试剂和第二试剂供给到检测部。 因此，可以防止未检测到的靶核酸单核心体被混合，并且核酸样品泄漏到外部。

    NUCLEIC ACID PROBE IMMOBILIZATION SUPPORT AND METHOD OF DETECTING TARGET NUCLEIC ACID USING THE SAME
    5.
    发明公开
    NUCLEIC ACID PROBE IMMOBILIZATION SUPPORT AND METHOD OF DETECTING TARGET NUCLEIC ACID USING THE SAME 审中-公开
    呆滞用于NUCLEIC的检测使用其的样品核酸和方法的固定化

    公开(公告)号：EP1586639A1

    公开(公告)日：2005-10-19

    申请号：EP02760765.4

    申请日：2002-08-28

    申请人： KABUSHIKI KAISHA TOSHIBA

    发明人： TAKAHASHI, Masayoshi ,  OKADA, Jun ,  HASHIMOTO, Koji

    IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/50

    CPC分类号： C12Q1/6837 ,  Y10T436/143333 ,  C12Q2525/197 ,  C12Q2525/161 ,  C12Q2563/107 ,  C12Q2563/113

    摘要： The invention provides a nucleic acid probe-immobilized substrate comprising a substrate and a nucleic acid probe containing a nucleotide sequence complementary to a target sequence and immobilized via a spacer onto the substrate, wherein upon hybridization, with the nucleic acid probe, of a target nucleic acid partially containing the target sequence, the spacer satisfies the relationship: X ≧ Y wherein X is the length of the spacer and Y is the length of the target nucleic acid ranging from the end of the hybridized site at the side of the substrate to the end of the target nucleic acid at the side of the substrate.

    摘要翻译： 本发明提供了核酸探针固定化基底，其包括靶核酸的一个基板和一个核酸探针包含与靶序列互补，并且通过间隔件固定到所述基板，worin杂交时的核苷酸序列，与所述核酸样品 酸部分含有靶序列，间隔SATIS外资企业的关系： X> / = Y worin X是间隔件的长度和Y为所述靶核酸从该杂交的端部的长度 站点的基板的与靶核酸的在所述基板的一侧的端部的一侧。

    BASE SEQUENCING ELECTRODE, BASE SEQUENCING DEVICE AND BASE SEQUENCING METHOD
    6.
    发明公开
    BASE SEQUENCING ELECTRODE, BASE SEQUENCING DEVICE AND BASE SEQUENCING METHOD 有权
    Basensequenzierungselektroden，Basensequenzierungsvorrichtung und Basensequenzierungsverfahren

    公开(公告)号：EP1445609A1

    公开(公告)日：2004-08-11

    申请号：EP02762891.6

    申请日：2002-08-28

    申请人： Kabushiki Kaisha Toshiba

    发明人： OKADA, Jun ,  HASHIMOTO, Koji ,  TAKAHASHI, Masayoshi

    IPC分类号： G01N27/416 ,  G01N27/30

    CPC分类号： C12Q1/6825 ,  C12Q2563/173 ,  C12Q2549/125

    摘要： A conductive detecting electrode (2), first blocking molecules (21) formed so as to cover a surface of the detecting electrode (2), the first blocking molecules decreasing adsorption of an intercalating agent to the surface of the detecting electrode (2), a target-complementary probe (23) immobilized to the detecting electrode (2) via a spacer member (22) comprising straight chain organic molecules, the target-complementary probe including a base sequence complementary to a target base sequence which is an object of detection, a conductive comparison electrode (3), and second blocking molecules (31) formed so as to cover a surface of the comparison electrode (3), the second blocking molecules decreasing adsorption of an intercalating agent to the surface of the comparison electrode (3), are provided.

    摘要翻译： 导电检测电极（2），形成为覆盖检测电极（2）的表面的第一阻挡分子（21），第一阻挡分子减少嵌入剂吸附到检测电极（2）的表面， 经由包含直链有机分子的间隔构件（22）固定在检测电极（2）上的目标互补探针（23），该靶互补探针包括与作为检测对象的目标碱基序列互补的碱基序列 ，导电比较电极（3）和形成为覆盖比较电极（3）的表面的第二阻挡分子（31），第二阻断分子减少插入剂对比较电极（3）的表面的吸附 ）。