公开(公告)号：EP1093818B1

公开(公告)日：2006-03-22

申请号：EP99926887.3

申请日：1999-07-01

申请人： Kirin-Amgen, Inc.

发明人： NOMURA, Hideaki Iyaku Kaihatsu Kenkyusho ,  UEKI, Yosuke Iyaku Kaihatsu Kenkyusho

IPC分类号： A61K38/00 ,  A61K9/14

CPC分类号： A61K9/006 ,  A61K9/0043 ,  A61K38/02 ,  A61K38/162 ,  A61K38/193 ,  A61K38/27 ,  A61K38/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： A powdery preparation for mucosal administration which comprises a polymeric medicine and a cationic polymer. The preparation is formed by adding a cationic polymer [especially an aminoalkyl methacrylate copolymer or poly(vinyl acetal diethylaminoacetate)] to a polymeric medicine, optionally further adding a thickening polymer, and powdering the mixture. Thus, the polymeric medicine can be effectively absorbed through a mucous membrane.

公开(公告)号：EP1093818B9

公开(公告)日：2007-10-17

申请号：EP99926887.3

申请日：1999-07-01

申请人： Kirin-Amgen, Inc.

发明人： NOMURA, Hideaki Iyaku Kaihatsu Kenkyusho ,  UEKI, Yosuke Iyaku Kaihatsu Kenkyusho

IPC分类号： A61K38/00 ,  A61K9/14

CPC分类号： A61K9/006 ,  A61K9/0043 ,  A61K38/02 ,  A61K38/162 ,  A61K38/193 ,  A61K38/27 ,  A61K38/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： A powdery preparation for mucosal administration which comprises a polymeric medicine and a cationic polymer. The preparation is formed by adding a cationic polymer [especially an aminoalkyl methacrylate copolymer or poly(vinyl acetal diethylaminoacetate)] to a polymeric medicine, optionally further adding a thickening polymer, and powdering the mixture. Thus, the polymeric medicine can be effectively absorbed through a mucous membrane.

公开(公告)号：EP1093818A1

公开(公告)日：2001-04-25

申请号：EP99926887.3

申请日：1999-07-01

申请人： Kirin-Amgen Inc.

发明人： NOMURA, Hideaki Iyaku Kaihatsu Kenkyusho ,  UEKI, Yosuke Iyaku Kaihatsu Kenkyusho

IPC分类号： A61K38/00 ,  A61K38/18 ,  A61K38/27 ,  A61K38/28 ,  A61K39/145 ,  A61K39/395 ,  A61K9/14 ,  A61K47/30 ,  A61K47/42

CPC分类号： A61K9/006 ,  A61K9/0043 ,  A61K38/02 ,  A61K38/162 ,  A61K38/193 ,  A61K38/27 ,  A61K38/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/38

摘要： A preparation in powder form for administration through mucosa, comprising a medicine of high molecular weight and a cationic polymer is disclosed.
By adding a cationic polymer (in particular, a copolymer of aminoalkylmethacrylate or polyvinyl acetal diethylaminoacetate) or a cationic polymer plus a viscous polymer to a medicine of high molecular weight for producing a preparation in powder form, it is possible to achieve effective absorption of the medicine of high molecular weight through mucosa.

摘要翻译： 在粉末形式的制剂用于给药通过粘膜，其包括高分子量药物和阳离子聚合物是游离缺失盘。 通过添加阳离子性聚合物（特别是氨基烷基或聚乙烯醇缩醛二乙基氨基乙的共聚物）或阳离子聚合物加上粘性聚合物，以高分子量的药物用于制造粉末形式的制剂，它能够实现的有效吸收 通过粘膜高分子量的药物。