公开(公告)号：EP2844324A1

公开(公告)日：2015-03-11

申请号：EP13784953.5

申请日：2013-04-30

申请人： Klein, Michael ,  Fisher, Joseph ,  Duffin, James ,  Slessarev, Marat ,  Kessler, Cathie ,  Ito, Shoji ,  Sobczyk, Olivia ,  Battisti-Charbonney, Anne ,  Mikulis, David ,  Mandell, Daniel Michael

发明人： Klein, Michael ,  Fisher, Joseph ,  Duffin, James ,  Slessarev, Marat ,  Kessler, Cathie ,  Ito, Shoji ,  Sobczyk, Olivia ,  Battisti-Charbonney, Anne ,  Mikulis, David ,  Mandell, Daniel Michael

IPC分类号： A61M16/00 ,  A61B5/021 ,  A61B5/08 ,  A61B5/091 ,  A61M16/06

CPC分类号： A61M16/0066 ,  A61B5/082 ,  A61B5/091 ,  A61M16/0045 ,  A61M16/026 ,  A61M16/1005 ,  A61M16/12 ,  A61M16/122 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/04 ,  A61M2230/202 ,  A61M2230/205 ,  A61M2230/208 ,  A61M2230/432 ,  A61M2230/435

摘要： An apparatus and method for controlling the end tidal partial pressure of a gas X in a subject's lung, and to the use of such an apparatus and method for research, diagnostic and therapeutic purposes, wherein the method consists of: - obtaining input of a series of logistically attainable PetX values for a series of respective breaths: - determining an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX for each of said respective breaths: and - controlling a gas delivery device to deliver the amount of gas in a volume of gas delivered to the subject in each of said respective breaths to target the respective PetX for that breath.

摘要翻译： 一种用于控制受检者肺中气体X的末端潮气分压的装置和方法以及这种装置和方法用于研究，诊断和治疗目的的用途，其中该方法包括： - 获得一系列的输入 在一系列相应呼吸中可以在物理上可达到的PetX值中： - 确定吸入气体中受试者吸入的气体量X，以针对所述各个呼吸中的每一个呼吸目标PetX：和 - 控制气体输送装置递送 在每次所述各呼吸中递送至对象的气体量中的气体量以针对该呼吸针对相应PetX。

公开(公告)号：EP2788063A1

公开(公告)日：2014-10-15

申请号：EP12856262.6

申请日：2012-12-05

申请人： Klein, Michael ,  Fisher, Joseph ,  Duffin, James ,  Slessarev, Marat ,  Kessler, Cathie ,  Ito, Shoji

发明人： Klein, Michael ,  Fisher, Joseph ,  Duffin, James ,  Slessarev, Marat ,  Kessler, Cathie ,  Ito, Shoji

IPC分类号： A61M16/10 ,  A61B5/08

CPC分类号： A61M16/0051 ,  A61B5/083 ,  A61B5/0833 ,  A61B5/0836 ,  A61B5/4836 ,  A61M16/0003 ,  A61M16/0069 ,  A61M16/026 ,  A61M16/085 ,  A61M16/0883 ,  A61M16/1005 ,  A61M16/12 ,  A61M16/122 ,  A61M2016/0021 ,  A61M2016/0027 ,  A61M2016/102 ,  A61M2016/1025 ,  A61M2016/103 ,  A61M2205/502 ,  A61M2230/43 ,  A61M2230/432 ,  A61M2230/435

摘要： A processor obtains input of a logistically attainable end tidal partial pressure of gas X (PetX[i]T) for one or more respective breaths [i] and input of a prospective computation of an amount of gas X required to be inspired by the subject in an inspired gas to target the PetX[i]T for a respective breath [i] using inputs required to utilize a mass balance relationship, wherein one or more values required to control the amount of gas X in a volume of gas delivered to the subject is output from an expression of the mass balance relationship. The mass balance relationship is expressed in a form which takes into account (prospectively), for a respective breath [i], the amount of gas X in the capillaries surrounding the alveoli and the amount of gas X in the alveoli, optionally based on a model of the lung which accounts for those sub-volumes of gas in the lung which substantially affect the alveolar gas X concentration affecting mass transfer.

公开(公告)号：EP2571422A1

公开(公告)日：2013-03-27

申请号：EP11782808.7

申请日：2011-05-18

申请人： Fisher, Joseph ,  Klein, Michael ,  Duffin, James

发明人： Fisher, Joseph ,  Klein, Michael ,  Duffin, James

IPC分类号： A61B5/08 ,  A61B5/026 ,  G06F19/00

CPC分类号： A61B5/0205 ,  A61B5/026 ,  A61B5/029 ,  A61B5/0813 ,  A61B5/0836 ,  A61B5/7225 ,  A61B5/7278 ,  A61M16/0057 ,  A61M16/12

摘要： A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non- invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a testcriterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.

摘要翻译： 一种使用迭代算法来控制气体输送装置的方法，所述装置可控变量使用迭代算法递送用于非侵入性地确定受试者的肺血流的测试气体（TG），包括迭代生成并评估迭代变量的测试值 算法，以输出满足测试标准的迭代变量的测试值，其中迭代算法的特征在于其定义了至少一个设备可控变量，迭代变量和获得的测试气体的终端潮汐浓度之间的测试数学关系 通过设置装置可控变量，使得迭代算法确定测试值上的迭代是否满足测试标准或迭代地生成逐渐改进的测试值。

公开(公告)号：EP2830693A1

公开(公告)日：2015-02-04

申请号：EP13768347.0

申请日：2013-03-28

申请人： Fisher, Joseph ,  Duffin, James ,  Ironstone, Joel

发明人： Fisher, Joseph ,  Duffin, James ,  Ironstone, Joel

IPC分类号： A61M16/10 ,  A61B5/08 ,  A61M16/00 ,  A61M16/18

CPC分类号： A61M16/183 ,  A61B5/087 ,  A61B5/4821 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/0057 ,  A61M16/0066 ,  A61M16/0075 ,  A61M16/0081 ,  A61M16/0093 ,  A61M16/01 ,  A61M16/024 ,  A61M16/0833 ,  A61M16/0891 ,  A61M16/18 ,  A61M16/22 ,  A61M2016/0027 ,  A61M2016/0039 ,  A61M2016/102 ,  A61M2016/1035 ,  A61M2202/048 ,  A61M2205/3303 ,  A61M2205/3334 ,  A61M2205/3389 ,  A61M2205/502 ,  A61M2230/42 ,  A61M2230/437 ,  A61M2202/0007

摘要： An anesthetic delivery system for use in conjunction with an anesthetic return system for reutilizing anesthetic exhaled by a subject, the system including a measurement system operatively connected to a breathing circuit for continuously measuring at least one flow parameter and anesthetic content of a gas stream reaching the subject and a control system for receiving input from the measurement system and controlling the amount of anesthetic entering the system, the control system including an input device for inputting a setting that corresponds to a desired amount of anesthetic in the gas stream reaching the subject, and utilizing a control algorithm for controlling the amount of anesthetic entering the system based on said desired amount of anesthetic, and flow and anesthetic content parameters as determined by the measurement system, such that the control algorithm is adapted to supplement anesthetic already in gas stream flowing to the subject to attain a level of anesthetic reaching the subject that correspond to the desired amount set via the input device.

摘要翻译： 一种麻醉剂输送系统，与麻醉返回系统一起用于重新利用受试者呼出的麻醉剂，该系统包括可操作地连接到呼吸回路的测量系统，用于连续测量至少一个流量参数和到达 主体和控制系统，用于接收来自测量系统的输入并控制进入系统的麻醉剂的量，控制系统包括输入装置，用于输入对应于到达对象的气体流中的期望量的麻醉剂的设置，以及 利用用于基于所述期望量的麻醉剂来控制进入系统的麻醉剂的量的控制算法，以及由测量系统确定的流量和麻醉剂含量参数，使得控制算法适于补充已经流入气流的麻醉剂 受试者达到麻醉反应水平 切换对应于经由输入装置设定的期望量的对象。

公开(公告)号：EP2827932A1

公开(公告)日：2015-01-28

申请号：EP13764140.3

申请日：2013-03-19

申请人： Klein, Michael ,  Fisher, Joseph

发明人： Klein, Michael ,  Fisher, Joseph

IPC分类号： A61M16/10 ,  A61B5/08 ,  A61B5/087

摘要： A respiratory gas delivery system monitors gas flow over the course of a breath in real time and uses this parameter to simulate, in whole or part, the function of a reference respiratory gas delivery system, in particular structural features, particularly structural components of parts of the reference system, to overcome a structural limitation of the reference system.

公开(公告)号：EP3003446A1

公开(公告)日：2016-04-13

申请号：EP14806925.5

申请日：2014-06-03

申请人： Klein, Michael ,  Fisher, Joseph

发明人： Klein, Michael ,  Fisher, Joseph

IPC分类号： A61M16/10 ,  A61B5/08 ,  A61M16/00

CPC分类号： A61B5/0836 ,  A61B5/0833 ,  A61M16/0045 ,  A61M16/0078 ,  A61M16/026 ,  A61M16/0891 ,  A61M16/104 ,  A61M16/12 ,  A61M16/125 ,  A61M16/208 ,  A61M2016/0027 ,  A61M2016/0036 ,  A61M2016/0039 ,  A61M2202/0208 ,  A61M2202/0225 ,  A61M2202/0241 ,  A61M2205/057 ,  A61M2230/43 ,  A61M2230/432 ,  A61M2230/435 ,  A61M2230/437

摘要： A system for controlling an amount of at least one gas X in a subject's lung to target at least one end tidal partial pressure of at least one gas X (PetX
T ), the system uses a control system for controlling the gas delivery device, wherein the control system implements a sequential gas delivery system and a feedback algorithm which compares a PetX
T for a respective breath [i] of variable size and preferably a respective current PetX value measured by a measurement system, to obtain an error signal, the feedback algorithm adapted for generating a control signal based on the error signal, the control signal determining the amount of gas X to be inspired by the subject in at least a first portion of a respective ensuing respective inspiratory cycle to target PetX
T for the respective interval.

公开(公告)号：EP2563438A1

公开(公告)日：2013-03-06

申请号：EP11774246.0

申请日：2011-05-02

申请人： Forte, Vito ,  Fisher, Joseph

发明人： Forte, Vito ,  Fisher, Joseph

IPC分类号： A61M16/00 ,  A61M16/04 ,  A61M16/20

CPC分类号： A61M16/0434 ,  A61M16/042 ,  A61M16/044 ,  A61M16/0452 ,  A61M16/0833 ,  A61M16/0858 ,  A61M16/204 ,  A61M16/206 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/0027 ,  A61M2016/0413 ,  A61M2016/1025 ,  A61M2202/0275 ,  A61M2202/0283 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/432 ,  A61M2230/50

摘要： Cuff pressure modulation results in decreased severity of injury to the subglottic region and upper trachea. A simple device is capable of modulating the pressure in the cuff of a regular endotracheal tube, by coordinating the pressure level to be maximal during the inspiratory phase and minimal during the expiratory phase. This allowed for regular positive airway pressure ventilation as during inspiration the seal was maintained between the ETT and the tracheal mucosa by the inflated cuff, but during expiration cuff deflation allowed the cuff pressure to drop in the subglottic and tracheal area.

公开(公告)号：EP2283270A1

公开(公告)日：2011-02-16

申请号：EP09737600.8

申请日：2009-05-01

申请人： Tijanic, Vesco ,  Fisher, Joseph ,  Kowalchuk, Bryan ,  Miller, Bryan Drew ,  Ramkhelawan, Kevin ,  Kowalchuk, Kevin ,  Ansel, Cliff ,  Dunn, David ,  Fedorko, Ludwik

发明人： Tijanic, Vesco ,  Fisher, Joseph ,  Kowalchuk, Bryan ,  Miller, Bryan Drew ,  Ramkhelawan, Kevin ,  Kowalchuk, Kevin ,  Ansel, Cliff ,  Dunn, David ,  Fedorko, Ludwik

IPC分类号： F16M13/02 ,  A61G1/04 ,  A61G12/00 ,  A61G7/05 ,  F16M11/04

CPC分类号： A61G1/04 ,  A61G13/101 ,  A61G2220/10

摘要： In one aspect, the invention is directed to a connector for connecting a medical device to a support member on a patient support device, such as a stretcher. The connector includes a support member connector that is fixedly connectable to the support member and a device connector for fixedly connecting to the medical device. The device connector is movable relative to the support member connector between a first position wherein the device connector is positioned to hold the medical device adjacent the patient support device and a second position that is inboard of the first position relative to the patient support device.

公开(公告)号：EP1383565A2

公开(公告)日：2004-01-28

申请号：EP02727094.1

申请日：2002-05-03

申请人： Fisher, Joseph ,  Veseley, Alex ,  Sasano, Hiroshi ,  Iscoe, Steve

发明人： Fisher, Joseph ,  Veseley, Alex ,  Sasano, Hiroshi ,  Iscoe, Steve

IPC分类号： A61M16/08 ,  A61M16/01 ,  A61M16/12 ,  A61B5/087

CPC分类号： A61B5/4821 ,  A61B5/0836 ,  A61B5/087 ,  A61M16/12 ,  A61M16/208 ,  A61M2202/0225 ,  Y10S128/914 ,  A61M2202/0007

摘要： A method is disclosed to maintain isocapnia when breathing exceeds baseline breathing and a circuit therefore. The circuit has a non rebreathing valve, a source of fresh gas, a fresh gas reservoir and a source of gas to be inhaled when minute ventilation exceeds fresh gas flow. The flow of fresh gas is equal to minute ventilation minus anatomic dead space, wherein additional inhaled gas exceeding fresh gas flow has a partial pressure of CO2 equal to the partial pressure of CO2 of arterial blood. Also disclosed is a method to identify the anatomic dead space and alveolar dead space by using a breathing circuit consisting of a non rebreathing valve, a source of fresh gas, a fresh gas reservoir and a source of gas with a partial pressure of CO2 substantially equal to that of arterial blood.

摘要翻译： 公开了一种当呼吸超过基线呼吸和电路时维持等碳酸血症的方法。 当每分钟通风量超过新鲜气体流量时，回路具有非再呼吸阀，新鲜气体源，新鲜气体储存器和气体源。 新鲜气体的流量等于每分通气量减去解剖死腔，其中额外的吸入气体超过新鲜气体流量具有等于动脉血的CO2分压的CO2分压。 还公开了一种通过使用由非再呼吸阀，新鲜气体源，新鲜气体储存器以及具有基本相等的CO2分压的气体源组成的呼吸回路来识别解剖死腔和肺泡死腔的方法 到动脉血。

公开(公告)号：EP1610852B1

公开(公告)日：2018-12-05

申请号：EP04711970.6

申请日：2004-02-18

申请人： Fisher, Joseph ,  Preiss, David ,  Azami, Takafumi ,  Vesely, Alex ,  Prisman, Eitan ,  Iscoe, Steve ,  Somogyi, Ron ,  Nayot, Dan ,  Adams, Tehilla

发明人： Fisher, Joseph ,  Preiss, David ,  Azami, Takafumi ,  Vesely, Alex ,  Prisman, Eitan ,  Iscoe, Steve ,  Somogyi, Ron ,  Nayot, Dan ,  Adams, Tehilla

IPC分类号： A61M16/08 ,  A61M16/20 ,  A61B5/083

CPC分类号： A61B5/4821 ,  A61B5/029 ,  A61B5/083 ,  A61B5/0836 ,  A61M16/0078 ,  A61M16/08 ,  A61M16/0833 ,  A61M16/0858 ,  A61M16/202 ,  A61M16/205 ,  A61M16/206 ,  A61M16/208 ,  A61M16/22 ,  A61M2016/0027

摘要： A breathing circuit for sequential gas delivery of a first gas set (FGS) and a second gas set (SGS) employs an arrangement of conduits and active or passive valves to prevent mixing of the FGS and SGS including a valve triggered by depletion of FGS that makes the SGS available for inspiration after the FGS is depleted.