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公开(公告)号：EP2208045A2
公开(公告)日：2010-07-21
申请号：EP08841093.1
申请日：2008-10-21
发明人： VERSCHUREN, Coen, A. , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J. , MEGENS, Mischa , VEEN, Jeroen , DE BOER, Bart, M. , JANSEN, Theodorus, P., H., G.
IPC分类号： G01N15/06
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a sensor device(100) and a method for the determination of the amount of target particles(1) at a contact surface(112) adjacent to a sample chamber(2). Target particles(1) in the sample chamber are detected by a sensor element(SE) and at least one corresponding sensor-signal (s, s') is provided. An evaluation unit(EU) then determines the amount of target particles(1) in a first zone(Z1) immediately at the contracts surface(112) and a second zone(Z2) a distance(z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidenceq) may be used to extract information about the first and second zones(Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently inthe first and second zone(Z2). Moreover, the temporalcourse of a sensor-signal(s, s') can be evaluated, particularly with respect to stochastic movements ofthe target particles(1).
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公开(公告)号：EP2453792A1
公开(公告)日：2012-05-23
申请号：EP10740334.7
申请日：2010-07-06
发明人： VEEN, Jeroen , MEFTAH, Mohammed , LAMBERT, Nicolaas , DE BOER, Bart, Michiel , FEDDES, Bastiaan , GOURMELON, Lena , RIETMAN, Ronald , HUSEN, Sri, Andari
IPC分类号： A61B5/0428
CPC分类号： A61B5/04284 , A61B5/7214 , A61B2562/0209 , A61B2562/046
摘要： An apparatus and method (4,5,6,7,2) for capacitive measurement of electrophysiological signals (1) suppresses or reduces motion artifacts by providing a feedback mechanism. An average voltage between a capacitive sensor electrode (1) and the body (3) is controlled so as to reduce or minimize motion-induced signals.
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">3.发明授权MONITORING A VITAL PARAMETER OF A PATIENT WITH "IN-SITU" MODULATION SCHEME TO AVOID INTERFERENCE 有权用“现场”调制方案监测患者的重要参数以避免干扰
公开(公告)号：EP2285271B1
公开(公告)日：2011-09-07
申请号：EP09766237.3
申请日：2009-06-09
发明人： VEEN, Jeroen , JANSEN, Theodorus, P., H., G. , VERBERNE, Henricus, R., M. , SCHENK, Tim, C., W. , FERI, Lorenzo
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0059
摘要： The invention relates to a method of monitoring a vital parameter of a patient by measuringattenuation of light emitted onto tissue of the patient, comprising the following steps: modulating the light with a modulation frequency or/and a modulation code; emitting the modulated light onto the tissue of the patient; collecting lightwhich is transmitted through the tissue or/and which is reflected from the tissue; demodulating the collected light; analyzing the demodulated collected light with regard to interference with ambient light; determining amodulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold; and setting the modulation frequency or/and the modulation code for modulating the light according to the determined modulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold. In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided.
摘要翻译： 本发明涉及一种通过测量发射到患者组织上的光的衰减来监测患者的生命参数的方法，包括以下步骤：以调制频率或/和调制码调制光; 将调制的光发射到患者的组织上; 收集透过组织或/和从组织反射的光; 解调收集的光; 分析关于干扰环境光的解调收集的光; 确定对环境光的干扰最小化或落入预定阈值的调制频率或/和调制码; 以及根据所确定的调制频率或/和调制代码设置用于调制光的调制频率或/和调制代码，所述调制代码对环境光的干扰被最小化或落入预定阈值以下。 以这种方式提供了监测具有高信号干扰比的患者的重要参数的通用和可靠的可能性。
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公开(公告)号：EP2005139A2
公开(公告)日：2008-12-24
申请号：EP07735241.7
申请日：2007-03-23
发明人： NIEUWENHUIS, Jeroen, H. , JANSEN, Theodorus, P., H., G. , VEEN, Jeroen , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J.
IPC分类号： G01N15/06 , G01R33/09 , G01N33/543 , G01R33/12 , G01N35/00
CPC分类号： G01R33/09 , B82Y25/00 , G01R33/007 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： A detection system (100, 150) for qualitative or quantitative detection of a magnetic field property of a modulated magnetic field is described. The modulated magnetic field may e.g. stem from an adjacent electrical current (Iadj) or magnetic particles. The detection system (100, 150) comprises at least one magneto resistive sensor element (102), a current controller (104) for providing a sensing current (Isense) flowing through the magnetic sensor element (102) and a controlling means (108). The controlling means (108) is adapted for deriving at a first frequency f1 a temperature-related parameter of the at least one magneto resistive sensor. The controlling means (108) furthermore is adapted for deriving a qualitative or quantitative characteristic of the adjacent electrical current (Iadj) or magnetic particles, taking into account the derived temperature-related parameter. This second frequency (f1) is different from the first frequency (f1}). The invention also relates to a corresponding method.
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5.发明公开
公开(公告)号：EP2175997A1
公开(公告)日：2010-04-21
申请号：EP07826834.9
申请日：2007-10-23
CPC分类号： G01R33/1269 , B01L3/502761 , B01L2200/0636 , B01L2400/043 , G01N21/552 , G01N27/745
摘要： The invention relates to a microelectronic sensor device for manipulating a sample in an exchangeable carrier (111), for example for optically detecting target particles (1) in a sample liquid that is provided in a sample chamber (2) of the carrier (111). The microelectronic sensor device comprises a number of n > 1 magnetic field generators (141-143), e.g. electromagnetic coils, with which magnetic fields can be generated in a target region (110). A control unit (150) is provided that can determine and evaluate the mutual coupling or the self-inductance of the magnetic field generators and/or signals from magnetic field sensors attached to the carrier with respect to the presence and/or state of a carrier (111) in the target region (110). In this way, the control unit (150) can for example detect if the carrier (111) is correctly positioned in the sensor device and/or where a magnetically interactive substance (1, 120) is located.
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6.发明公开
公开(公告)号：EP2095121A2
公开(公告)日：2009-09-02
申请号：EP07849455.6
申请日：2007-12-12
IPC分类号： G01N33/543 , G01R33/09 , G01R33/12
CPC分类号： G01R33/093 , B82Y25/00 , G01R33/1269
摘要： The invention relates to a magnetic sensor device for the determination of magnetized particles (3) which comprises a magnetic field generator (1, 1') (e.g. a conductor wire) that is driven with an excitation current (II) of a first frequency (f1), and a magnetic sensor element (2) (e.g. a GMR resistance), that is driven with a sensor current (I2) of a second frequency (f2) for generating measurement signals (UGMR). A preprocessed signal (uf) is then generated from the measurement signal (UGMR) that comprises a predetermined frequency (Δf), and an evaluation unit (10) separates from this preprocessed signal a spurious component that does not depend on the presence of magnetized particles (3) in the sample chamber. The spurious component (UQ) may particularly be caused by self-magnetization (H2) of the magnetic sensor element (2) in combination with parasitic (capacitive or inductive) cross-talk. Furthermore, an unknown, variable phase-shift (φSP) in the preprocessed signal (uf) may be determined by varying the ratio between the spurious component and a particle-dependent target component. This variation may for example be achieved if, in an optimization stage (OS), the excitation current (I1) is conducted through a bypass resistor (R, R') and/or if an additional capacitor is introduced between the magnetic field generator and the magnetic sensor element. The determined phase shift can then be used to adjust the phase of a demodulation signal (udem) such that the spurious component is suppressed.
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7.发明公开SENSOR DEVICE COMPRISING MEANS FOR DETERMINING THE SAMPLE COVERED AREA OF THE SENSITIVE SURFACE 审中-公开有装置传感器一种用于确定敏感区域的样本覆盖区
公开(公告)号：EP2095099A1
公开(公告)日：2009-09-02
申请号：EP07849424.2
申请日：2007-12-11
CPC分类号： G01N13/00 , G01N27/745 , G01N33/54326 , G01R33/1269
摘要： The invention relates to a microelectronic device (100) with means for the determination of the wetting grade of a sensitive surface (22) that lies adjacent to a sample chamber (1) with a sample fluid. In a particular embodiment, the device may be a magnetic sensor device comprising magnetic excitation wires (11, 13) for the generation of magnetic fields (B) in the sample chamber and a GMR sensor (12) for sensing reaction fields (B') generated by magnetized particles (2). A detector module (30) can optionally be adapted to measure the resistance of conductors (11, 12, 13) which depends, via the dissipation of heat generated by electrical currents, on the wetting grade of the sensitive surface (22). In another embodiment, the capacitance of conductors is measured, which is affected at the sensitive surface by the presence of gas bubbles (4).
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公开(公告)号：EP2440124A1
公开(公告)日：2012-04-18
申请号：EP10727948.1
申请日：2010-06-08
发明人： VEEN, Jeroen , DE WAELE, Stijn
CPC分类号： A61B5/16 , A61B5/0402 , A61B5/04842 , A61B5/04845 , A61B5/04847 , A61N1/00 , A61N1/36
摘要： A system for conditioning an organism by associating a conditioned response with a conditioned stimulus, the system comprising the following. Identifying means for identifying a signal pattern associated with a conditioned response (201). Measuring means for measuring a signal of the organism for obtaining a measured signal (202). A comparer for comparing the measured signal with the signal pattern (203). A stimulus renderer for rendering a conditioned stimulus (204) when the measured signal matches the signal pattern, for conditioning the organism such that it associates the conditioned stimulus with the conditioned response, and for further rendering the conditioned stimulus for evoking the conditioned response, at a time which depends on the measured signal.
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公开(公告)号：EP2208045B9
公开(公告)日：2012-01-04
申请号：EP08841093.1
申请日：2008-10-21
发明人： VERSCHUREN, Coen, A. , KAHLMAN, Josephus, A., H., M. , IMMINK, Albert, H., J. , MEGENS, Mischa , VEEN, Jeroen , DE BOER, Bart, M. , JANSEN, Theodorus, P., H., G.
IPC分类号： G01N15/06
CPC分类号： G01N15/06 , G01N15/0656 , G01N2015/0693 , G01R33/1269
摘要： The invention relates to a sensor device(100) and a method for the determination of the amount of target particles(1) at a contact surface(112) adjacent to a sample chamber(2). Target particles(1) in the sample chamber are detected by a sensor element(SE) and at least one corresponding sensor-signal (s, s') is provided. An evaluation unit(EU) then determines the amount of target particles(1) in a first zone(Z1) immediately at the contracts surface(112) and a second zone(Z2) a distance(z) away from the contact surface based on this sensor-signal. In an optical measurement approach, frustrated total internal reflection taking place under different operating conditions (e.g. wavelength, angle of incidenceq) may be used to extract information about the first and second zones(Z1, Z2). In a magnetic measurement approach, different magnetic excitation fields may be used to excite magnetic target particles differently inthe first and second zone(Z2). Moreover, the temporalcourse of a sensor-signal(s, s') can be evaluated, particularly with respect to stochastic movements ofthe target particles(1).
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">10.发明公开MONITORING A VITAL PARAMETER OF A PATIENT WITH "IN-SITU" MODULATION SCHEME TO AVOID INTERFERENCE 有权监测患者的一个重要参数随原位调制方案避免干扰
公开(公告)号：EP2285271A1
公开(公告)日：2011-02-23
申请号：EP09766237.3
申请日：2009-06-09
发明人： VEEN, Jeroen , JANSEN, Theodorus, P., H., G. , VERBERNE, Henricus, R., M. , SCHENK, Tim, C., W. , FERI, Lorenzo
IPC分类号： A61B5/00
CPC分类号： A61B5/14551 , A61B5/0059
摘要： The invention relates to a method of monitoring a vital parameter of a patient by measuringattenuation of light emitted onto tissue of the patient, comprising the following steps: modulating the light with a modulation frequency or/and a modulation code; emitting the modulated light onto the tissue of the patient; collecting lightwhich is transmitted through the tissue or/and which is reflected from the tissue; demodulating the collected light; analyzing the demodulated collected light with regard to interference with ambient light; determining amodulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold; and setting the modulation frequency or/and the modulation code for modulating the light according to the determined modulation frequency or/and a modulation code for which interference with the ambient light is minimized or falls under a predefined threshold. In this way a versatile and reliable possibility of monitoring a vital parameter of a patient with a high signal-to-interference ratio is provided.
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