公开(公告)号：EP1756742A2

公开(公告)日：2007-02-28

申请号：EP05738386.1

申请日：2005-05-20

申请人： Philips Intellectual Property & Standards GmbH ,  Koninklijke Philips Electronics N.V.

发明人： PELIGRAD, Dragos-Nicolae ,  SPIES, Lothar ,  PAULUS, Timo

IPC分类号： G06F19/00

CPC分类号： G06F19/321 ,  G06F19/00 ,  G16H10/40

摘要： The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (Cp) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (SINJ(t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

公开(公告)号：EP2041720A2

公开(公告)日：2009-04-01

申请号：EP07789837.7

申请日：2007-06-29

申请人： Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

发明人： PAULUS, Timo ,  WENGLER, Mark C.

IPC分类号： G06T7/00

CPC分类号： G06T7/0012 ,  G06T2207/10076 ,  G06T2207/30004

摘要： This relates to a method of automatically selecting preferred voxels from a group of voxels for pharmacokinetic modeling of a biological system, where the voxels contain data points indicating a change of activity-levels over time. For each respective voxel the changes of the data points over time with at least one noise level value, where the comparing is performed in accordance to a pre-defined selection rule. Then, those voxels where the result of the comparing obeys the selection rule are then selected as preferred voxels.

公开(公告)号：EP2050068A2

公开(公告)日：2009-04-22

申请号：EP07805180.2

申请日：2007-07-17

申请人： Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

发明人： WENGLER, Mark Christof ,  PAULUS, Timo ,  FISCHER, Alexander

IPC分类号： G06T7/00

CPC分类号： G06K9/6253 ,  G06K9/6218 ,  G06K9/6292 ,  G06K9/6293 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/143 ,  G06T2207/10072 ,  G06T2207/30004

摘要： This invention relates to a method of combining multiple binary cluster maps into a single cluster map; where each respective binary cluster map represents characteristic information and the single cluster map represent the sum of the characteristic information. Initially, each respective binary cluster map is assigned with a reliability factor for indicating the reliability of the binary cluster map. These factor values are then used to determine a reliability vector comprising reliability factor elements, where each respective reliability factor element is associated to certain cluster map area in the single cluster map and indicates the reliability of the cluster map area. In that way, the single cluster map can be viewed with respect to the reliability.

摘要翻译： 本发明涉及将多个二进制簇映射组合成单个簇映射的方法; 其中每个相应的二进制集群映射表示特征信息，并且单个集群映射表示特征信息的和。 首先，为每个相应的二进制簇映射图分配用于指示二进制簇映射的可靠性的可靠性因子。 然后使用这些因子值来确定包括可靠性因子元素的可靠性向量，其中每个相应的可靠性因素元素与单个集群映射中的某些集群映射区域相关联并且指示集群映射的可靠性。 以这种方式，可以相对于可靠性来查看单个集群映射。

公开(公告)号：EP2174292A1

公开(公告)日：2010-04-14

申请号：EP07805303.0

申请日：2007-08-03

申请人： Koninklijke Philips Electronics N.V. ,  Philips Intellectual Property & Standards GmbH

发明人： PAULUS, Timo ,  FISCHER, Alexander ,  SPIES, Lothar

IPC分类号： G06T7/00

CPC分类号： G06T7/0016 ,  G06T7/207 ,  G06T2207/10076 ,  G06T2207/10104 ,  G06T2207/20016 ,  G06T2207/20021 ,  G06T2207/30004

摘要： An advantageous method, apparatus, computer-readable medium, and use for improving the estimation of relevant initial parameters for parameter reconstruction processes in molecular imaging are disclosed, resulting in shorter process times and more robust results with small confidence intervals.

摘要翻译： 公开了一种有利的方法，装置，计算机可读介质和用于改进分子成像中的参数重建过程的相关初始参数的估计的用途，导致较短的处理时间和更小的置信区间的更稳健的结果。

公开(公告)号：EP1910960A2

公开(公告)日：2008-04-16

申请号：EP06780035.9

申请日：2006-07-11

申请人： Koninklijke Philips Electronics N.V.

发明人： FISCHER, Alexander ,  PAULUS, Timo

IPC分类号： G06F19/00

CPC分类号： G06F17/18 ,  G16H50/50

摘要： This system ( 200 ), apparatus ( 300 ), and method ( 100 ) of the present invention provide an analytic way to solve the (input) estimation problem of pharmacokinetic modeling: estimating parameters of a kinetic model from a series of tracer (radioactively labeled imaging agent) activity measurements (e.g. by positron emission tomography). Since the model describes a biological process its parameters have a direct functional interpretation (e.g. hypoxia for the tracer FMISO) that can be of diagnostic value. The measurements represent the activity distribution in time and space in the form of a 4D data set d(t, x, y, z), t=1, . . . , T. The kinetic parameter estimation procedure ( 205 ) requires knowledge of the tracer input activity. This input activity can either be measured invasively or it can be estimated from the data in a preprocessing step. The estimation problem can be solved efficiently if the model and its input are described analytically. Typically parameterized functions (often sums of exponential terms) ( 204 ) are fitted to the averaged data over a region of interest (ROI) (e.g. an artery or the left ventricular blood pool) in order to obtain an analytical input representation. The input function representation (functional form) ( 204 ) and its initial parameter values ( 205 ) have to be selected/specified prior to the fitting procedure 206 ). The present invention thereby reduces the amount of manual interaction and operator dependence in the evaluation of dynamic procedures.