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    RECOMBINANT MICROORGANISM WITH INCREASED BUTANOL PRODUCTION ABILITY, AND PREPARATION METHOD OF BUTANOL USING SAME
    1.
    发明授权
    RECOMBINANT MICROORGANISM WITH INCREASED BUTANOL PRODUCTION ABILITY, AND PREPARATION METHOD OF BUTANOL USING SAME 有权
    重组微生物提高丁醇生产能力，以及使用相同的丁醇制备方法

    公开(公告)号：EP2481793B1

    公开(公告)日：2017-08-30

    申请号：EP10819056.2

    申请日：2010-09-21

    申请人： Korea Advanced Institute of Science and Technology ,  Biofuelchem Co. ,  GS Caltex Corporation

    发明人： LEE, Sang Yup ,  JANG, Yu-Sin ,  LEE, Jin Young ,  LEE, Joung Min ,  PARK, Jin Hwan

    IPC分类号： C12N1/21 ,  C12P7/16 ,  C12N15/52

    CPC分类号： C12P7/16 ,  C12N9/0006 ,  C12N9/1029 ,  C12Y101/01001 ,  C12Y203/01008 ,  C12Y203/01019 ,  Y02E50/10

    摘要： The present invention relates to recombinant microorganisms having an increased ability to produce butanol, and a method of producing butanol using the same. More specifically, the invention relates to recombinant microorganisms whose ability to produce butanol was increased by manipulation of their metabolic networks, and a method of producing butanol using the same. The recombinant microorganisms having an increased ability to produce butanol comprise a deletion of a gene, which encodes an enzyme that converts acetyl CoA to acetate, in host microorganisms having genes that encode enzymes involved in acetyl CoA and butyryl CoA biosynthetic pathway. The recombinant microorganisms obtained by manipulating the metabolic flux of microorganisms are able to selectively produce butanol with high efficiency, and thus are useful as microorganisms for producing industrial solvents and transportation fuels.

    摘要翻译： 本发明涉及具有提高的丁醇生产能力的重组微生物以及使用该微生物生产丁醇的方法。 更具体地说，本发明涉及通过操作其代谢网络来增加丁醇生产能力的重组微生物，以及使用该微生物生产丁醇的方法。 具有增加的丁醇生产能力的重组微生物包括在编码参与乙酰辅酶A和丁酰辅酶A生物合成途径的酶的基因的宿主微生物中缺失编码将乙酰辅酶A转化为乙酸的酶的基因。 通过操作微生物的代谢流而获得的重组微生物能够高效选择性地生产丁醇，因此可用作用于生产工业溶剂和运输燃料的微生物。