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10 条记录 (耗时 0.016 秒)

    RECOMBINANT MICROORGANISM WITH INCREASED BUTANOL PRODUCTION ABILITY, AND PREPARATION METHOD OF BUTANOL USING SAME
    2.
    发明授权
    RECOMBINANT MICROORGANISM WITH INCREASED BUTANOL PRODUCTION ABILITY, AND PREPARATION METHOD OF BUTANOL USING SAME 有权
    重组微生物提高丁醇生产能力，以及使用相同的丁醇制备方法

    公开(公告)号：EP2481793B1

    公开(公告)日：2017-08-30

    申请号：EP10819056.2

    申请日：2010-09-21

    申请人： Korea Advanced Institute of Science and Technology ,  Biofuelchem Co. ,  GS Caltex Corporation

    发明人： LEE, Sang Yup ,  JANG, Yu-Sin ,  LEE, Jin Young ,  LEE, Joung Min ,  PARK, Jin Hwan

    IPC分类号： C12N1/21 ,  C12P7/16 ,  C12N15/52

    CPC分类号： C12P7/16 ,  C12N9/0006 ,  C12N9/1029 ,  C12Y101/01001 ,  C12Y203/01008 ,  C12Y203/01019 ,  Y02E50/10

    摘要： The present invention relates to recombinant microorganisms having an increased ability to produce butanol, and a method of producing butanol using the same. More specifically, the invention relates to recombinant microorganisms whose ability to produce butanol was increased by manipulation of their metabolic networks, and a method of producing butanol using the same. The recombinant microorganisms having an increased ability to produce butanol comprise a deletion of a gene, which encodes an enzyme that converts acetyl CoA to acetate, in host microorganisms having genes that encode enzymes involved in acetyl CoA and butyryl CoA biosynthetic pathway. The recombinant microorganisms obtained by manipulating the metabolic flux of microorganisms are able to selectively produce butanol with high efficiency, and thus are useful as microorganisms for producing industrial solvents and transportation fuels.

    摘要翻译： 本发明涉及具有提高的丁醇生产能力的重组微生物以及使用该微生物生产丁醇的方法。 更具体地说，本发明涉及通过操作其代谢网络来增加丁醇生产能力的重组微生物，以及使用该微生物生产丁醇的方法。 具有增加的丁醇生产能力的重组微生物包括在编码参与乙酰辅酶A和丁酰辅酶A生物合成途径的酶的基因的宿主微生物中缺失编码将乙酰辅酶A转化为乙酸的酶的基因。 通过操作微生物的代谢流而获得的重组微生物能够高效选择性地生产丁醇，因此可用作用于生产工业溶剂和运输燃料的微生物。

    L-THREONINE OVERPRODUCING MICROORGANISM AND METHOD FOR PREPARING L-THREONINE USING THE SAME
    6.
    发明公开
    L-THREONINE OVERPRODUCING MICROORGANISM AND METHOD FOR PREPARING L-THREONINE USING THE SAME 有权
    L-苏氨酸过量产生微生物及其制备L-苏氨酸的方法

    公开(公告)号：EP2121918A1

    公开(公告)日：2009-11-25

    申请号：EP07768570.9

    申请日：2007-07-02

    申请人： Korea Advanced Institute of Science and Technology

    发明人： LEE, Sang Yup ,  LEE, Kwang Ho ,  PARK, Jin Hwan ,  KIM, Tae Yong, Korea Advanced Institute of Science & Technology

    IPC分类号： C12N15/09 ,  C12N1/21 ,  C12P13/08

    CPC分类号： C12P13/08

    摘要： The present invention relates to a mutant microorganism producing a high concentration of L-threonine in high yield, prepared using site-specific mutation, not random mutation, such as treatment with a mutation inducer, a method for preparing the same, and a method for preparing L-threonine using the mutant microorganism producing L-threonine. By using the mutant microorganism according to the present invention, L-threonine can be prepared at high yield, additional strain development becomes possible and their physiological phenomena can be easily understood since genetic information of L-threonine producing microorganism can be identified.

    摘要翻译： 本发明涉及使用位点特异性突变而不是随机突变（例如用突变诱导剂处理）制备高产率L-苏氨酸的突变体微生物，其制备方法以及用于制备高浓度L-苏氨酸的方法 使用产生L-苏氨酸的突变微生物制备L-苏氨酸。 通过使用根据本发明的突变微生物，可以高收率地制备L-苏氨酸，由于可以鉴定产生L-苏氨酸的微生物的遗传信息，因此可以进一步发展菌株发育并且可以容易地理解它们的生理现象。

    MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME
    7.
    发明公开
    MUTANT MICROORGANISM HAVING IMPROVED PRODUCTION ABILITY OF BRANCHED AMINO ACID AND METHOD FOR PREPARING BRANCHED AMINO ACID USING THE SAME 审中-公开
    支链氨基酸提高生产能力的突变微生物及用其制备支链氨基酸的方法

    公开(公告)号：EP2038403A1

    公开(公告)日：2009-03-25

    申请号：EP07715659.4

    申请日：2007-03-14

    申请人： Korea Advanced Institute of Science and Technology

    发明人： LEE, Sang Yup ,  PARK, Jin Hwan ,  LEE, Kwang Ho ,  KIM, Tae Yong

    IPC分类号： C12N1/16

    CPC分类号： C12P13/08 ,  C12N9/1014 ,  C12Y201/02011

    摘要： The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site- specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine.

    摘要翻译： 本发明涉及具有提高的支链氨基酸生产率的突变微生物以及使用该突变微生物生产支链氨基酸的方法。 更具体地，涉及通过减弱或缺失编码参与L-异亮氨酸生物合成的酶的基因，编码参与L-亮氨酸的酶的基因和编码L-异亮氨酸生物合成酶的基因而产生的L-缬氨酸的生产率提高的突变微生物 参与D-泛酸生物合成的酶，以及编码参与L-缬氨酸生物合成的酶的基因的突变，从而增加其表达，以及使用该突变体微生物生产L-缬氨酸的方法。 通过位点特异性诱变和代谢途径工程产生的本发明的突变微生物可高效生产支链氨基酸，特别是L-缬氨酸，因此可用作生产L-缬氨酸的工业微生物。