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    NOVEL PHENYLPYRIDINE DERIVATIVE AND DRUG CONTAINING SAME
    4.
    发明公开
    NOVEL PHENYLPYRIDINE DERIVATIVE AND DRUG CONTAINING SAME 有权
    关于ARZNEIMITTEL DAMIT的隐形眼镜

    公开(公告)号：EP2687523A1

    公开(公告)日：2014-01-22

    申请号：EP12757676.7

    申请日：2012-03-13

    申请人： Kowa Company Ltd.

    发明人： MIURA, Toru ,  SATO, Seiichi ,  YAMADA, Hajime ,  TAGASHIRA, Junya ,  WATANABE, Toshiaki ,  SEKIMOTO, Ryohei ,  ISHIDA, Rie ,  AOKI, Hitomi ,  OHGIYA, Tadaaki

    IPC分类号： C07D401/14 ,  A61K31/506 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P25/18 ,  A61P27/02 ,  A61P43/00 ,  C07D413/14

    CPC分类号： C07D413/14 ,  A61K31/506 ,  C07D401/14

    摘要： The present invention provides: a compound represented by general formula (I) below, that has both angiotensin II receptor antagonism and a PPARγ activation effect and that is useful as a preventative and/or therapeutic agent for high blood pressure, cardiac disease, arteriosclerosis, type-2 diabetes, and the like; and a drug composition containing the compound. General formula (I) (in the formula: ring A represents a pyridine ring; ring B represents a tetrazole ring or an oxadiazol-5 (4H) -one ring; X represents C-R 5 or a nitrogen atom; R 1 represents an alkyl group; R 2 represents an alkyl group or a cycloalkyl group; and R 3 , R 4 , and R 5 each independently represents a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or similar.

    摘要翻译： 本发明提供：下述通式（I）表示的化合物，其具有血管紧张素II受体拮抗作用和PPAR 3活化作用，并且可用作高血压，心脏病，动脉硬化等的预防和/或治疗剂， 2型糖尿病等; 和含有该化合物的药物组合物。 通式（I）（式中，环A表示吡啶环，环B表示四唑环或恶二唑-5-（4H） - 酮环，X表示CR 5或氮原子，R 1表示烷基 R 2表示烷基或环烷基; R 3，R 4和R 5各自独立地表示氢原子，卤素原子，烷基，烷氧基等。

    NOVEL -PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME
    5.
    发明公开
    NOVEL -PHENOXYBENZENEACETIC ACID DERIVATIVE AND PHARMACEUTICAL PREPARATION COMPRISING SAME 审中-公开
    在药物治疗前必须使用阿尔法 - 苯氧基苯甲酸衍生物

    公开(公告)号：EP2436675A1

    公开(公告)日：2012-04-04

    申请号：EP10780296.9

    申请日：2010-05-28

    申请人： Kowa Company, Ltd.

    发明人： MIURA, Toru ,  ONOGI, Kazuhiro ,  TAGASHIRA, Junya ,  WATANABE, Gen ,  SEKIMOTO, Ryohei ,  ISHIDA, Rie ,  AOKI, Hitomi ,  OHGIYA, Tadaaki

    IPC分类号： C07D239/34 ,  A61K31/505 ,  A61K31/506 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00 ,  C07D239/36 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D413/14

    CPC分类号： C07D401/04 ,  C07D239/34 ,  C07D239/36 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/14

    摘要： An α-phenoxybenzeneacetic acid derivative represented by general formula (I), which has both an angiotensin II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, metabolic syndrome or the like, a salt of the derivative, or a solvate of the derivative or the salt; and a pharmaceutical composition containing the derivative, the salt or the solvate. [In the formula, Q represents a group represented by formula (II) or (III) [wherein R 1 and R 1' independently represent a C 1-6 alkyl group; R 2 and. R 2' independently represent a substituted or unsubstituted C 1-6 alkyl group; R 3 represents a hydrogen atom, a substituted or unsubstituted C 1-6 alkyl group, or a group represented by formula (IV) [wherein X and Y independently represent CH or N; Z represents a C 1-6 alkylene chain, or the like; R 11 represents a hydrogen atom, a C 6-10 aryl group, or the like; and m represents 0 or 1] ; and R 4 represents a substituted C 1-6 alkyl group]; R 5 and R 6 independently represent a C 1-6 alkyl group: R 7 represents a carboxyl group, or the like; R 8 , R 9 and R 10 independently represent a hydrogen atom, a halogen atom, or the like; and n represents an integer of 1 to 3.]

    摘要翻译： 由通式（I）表示的± - 苯氧基苯乙酸衍生物，其具有血管紧张素II受体拮抗作用和PPAR 3活化活性，可用作高血压，代谢综合征等的预防和/或治疗剂，盐 的衍生物，或衍生物或盐的溶剂合物; 和含有衍生物，盐或溶剂化物的药物组合物。 [式中，Q表示由式（II）或（III）表示的基团[其中R 1和R 1'独立地表示C 1-6烷基; R 2和。 R 2'独立地表示取代或未取代的C 1-6烷基; R 3表示氢原子，取代或未取代的C 1-6烷基或由式（IV）表示的基团[其中X和Y独立地表示CH或N; Z表示C 1-6亚烷基链等; R 11表示氢原子，C 6-10芳基等; m表示0或1]; R 4表示取代的C 1-6烷基]; R 5和R 6独立地表示C 1-6烷基：R 7表示羧基等; R 8，R 9和R 10独立地表示氢原子，卤素原子等; n表示1〜3的整数。

    NOVEL PHENYLPYRIDINE DERIVATIVE AND MEDICINAL AGENT COMPRISING SAME
    6.
    发明公开
    NOVEL PHENYLPYRIDINE DERIVATIVE AND MEDICINAL AGENT COMPRISING SAME 有权
    隐形眼镜中的隐形眼镜

    公开(公告)号：EP2484675A1

    公开(公告)日：2012-08-08

    申请号：EP10820125.2

    申请日：2010-09-29

    申请人： Kowa Company, Ltd.

    发明人： MIURA, Toru ,  SATO, Seiichi ,  YAMADA, Hajime ,  TAGASHIRA,Junya ,  SEKIMOTO, Ryohei ,  ISHIDA, Rie ,  AOKI, Hitomi ,  OHGIYA, Tadaaki

    IPC分类号： C07D401/14 ,  A61K31/506 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P25/00 ,  A61P27/02 ,  A61P43/00 ,  C07D413/14

    CPC分类号： C07D401/14 ,  A61K31/422 ,  A61K31/4427 ,  C07D413/14

    摘要： Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C-R 5 or a nitrogen atom; R 1 represents a C 1-6 alkyl group; R 2 represents a C 1-6 alkyl group or a C 3-8 cycloalkyl group; and R 3 , R 4 , R 5 independently represent a hydrogen atom, a halogen atom, a C 1-6 alkyl group, a halo-C 1-6 alkyl group, or a C 1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.

    摘要翻译： 公开了一种对血管紧张素II受体具有拮抗作用和PPAR 3活化活性的新型化合物，因此可用作高血压，心脏病，动脉硬化，2型糖尿病，糖尿病并发症的预防和/或治疗剂 ，代谢综合征等; 和含有该化合物的药物组合物。 具体公开的是：由通式（I）表示的化合物（其中环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示CR 5或氮原子 R 1表示C 1-6烷基; R 2表示C 1-6烷基或C 3-8环烷基; R 3，R 4，R 5独立地表示氢原子，卤素原子， 可以具有取代基的C 1-6烷基，卤代C 1-6烷基或C 1-6烷氧基，化合物的盐或化合物或其盐的溶剂合物; 和含有化合物，盐或溶剂合物的药物组合物。

    NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME
    7.
    发明公开
    NOVEL SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME 审中-公开
    消除药物治疗

    公开(公告)号：EP2471782A1

    公开(公告)日：2012-07-04

    申请号：EP10811524.7

    申请日：2010-08-27

    申请人： Kowa Company, Ltd.

    发明人： MIURA, Toru ,  ONOGI, Kazuhiro ,  GOMI, Noriaki ,  ARAKI, Takaaki ,  TAGASHIRA, Junya ,  SEKIMOTO, Ryohei ,  ISHIDA, Rie ,  AOKI, Hitomi ,  OHGIYA, Tadaaki

    IPC分类号： C07D239/36 ,  A61K31/513 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/10 ,  A61P43/00

    CPC分类号： C07D403/04

    摘要： Disclosed is a novel compound which has both angiotensin II receptor antagonist activity and PPARγ activating activity, and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, kidney diseases, arteriosclerosis, inflammatory diseases, type 2 diabetes, diabetic complication, insulin resistant syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. Also disclosed is a pharmaceutical composition which contains the novel compound. Specifically disclosed are: a sulfonamide derivative represented by general formula (I), a salt thereof, or a solvate of the derivative or salt; and a pharmaceutical composition which contains the sulfonamide derivative, a salt thereof, or a solvate of the derivative or salt. (In the formula, R 1 represents a C 1-6 alkyl group; R 2 and R 3 each represents a C 1-6 alkyl group or the like; and R 4 represents a hydrogen atom, a C 1-6 alkyl group, a C 1-6 alkanoyl group or a C 3-8 cycloalkylcarbonyl group.)

    摘要翻译： 公开了具有血管紧张素II受体拮抗剂活性和PPAR 3活化活性的新型化合物，可用作高血压，心脏病，心绞痛，脑血管障碍，脑循环障碍，缺血性外周循环障碍等的预防和/ 肾脏疾病，动脉硬化，炎性疾病，2型糖尿病，糖尿病并发症，胰岛素抵抗综合征，X综合症，代谢综合征和高胰岛素血症。 还公开了含有新化合物的药物组合物。 具体公开的是：由通式（I）表示的磺酰胺衍生物，其盐或衍生物或盐的溶剂合物; 以及含有磺酰胺衍生物，其盐或衍生物或盐的溶剂合物的药物组合物。 （式中，R 1表示C 1-6烷基，R 2和R 3各自表示C 1-6烷基等，R 4表示氢原子，C 1-6烷基， C 1-6烷酰基或C 3-8环烷基羰基）