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1.发明公开NOUVEAUX ANTICORPS HUMANISES 12G4 MUTES ET LEURS FRAGMENTS DIRIGES CONTRE LE RECEPTEUR HUMAIN DE L'HORMONE ANTI-MULLERIENNE DE TYPE II 有权新突变型从人性化的12G4抗体和片段中抗人抗MUELLER激素II型受体
公开(公告)号：EP2569333A1
公开(公告)日：2013-03-20
申请号：EP11718450.7
申请日：2011-04-01
申请人： LFB Biotechnologies , Université Montpellier I , Centre National de Lutte contre le Cancer , INSERM (Institut National de la Santé et de la Recherche Médicale)
CPC分类号： C07K16/2863 , A61K31/282 , A61K31/337 , A61K31/7088 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2869 , C07K16/46 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/92 , G01N33/57449 , G01N2333/72
摘要： The invention relates to novel mutated humanized 12G4 antibodies and to the fragments thereof against the anti-Müllerian hormone receptor type II.
摘要翻译： 新颖突变的人源化抗体12G4，以及它们的片段，针对抗苗勒激素II型受体。
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2.发明授权NOUVEAUX ANTICORPS HUMANISES 12G4 MUTES ET LEURS FRAGMENTS DIRIGES CONTRE LE RECEPTEUR HUMAIN DE L'HORMONE ANTI-MULLERIENNE DE TYPE II 有权新型12G4突变型人源化抗体及其片段指向人类II型抗甲状腺激素受体
公开(公告)号：EP2569333B1
公开(公告)日：2017-12-13
申请号：EP11718450.7
申请日：2011-04-01
申请人： Laboratoire Français du Fractionnement et des Biotechnologies , Université Montpellier I , Centre Régional de Lutte contre le Cancer , INSERM (Institut National de la Santé et de la Recherche Médicale)
IPC分类号： C07K16/00 , C07K16/28 , C07K16/30 , A61K31/282 , A61K39/395 , A61K31/337 , A61K31/7088 , A61K33/24 , C07K16/46 , A61K39/00
CPC分类号： C07K16/2863 , A61K31/282 , A61K31/337 , A61K31/7088 , A61K33/24 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2869 , C07K16/46 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/92 , G01N33/57449 , G01N2333/72
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公开(公告)号：EP2408813A2
公开(公告)日：2012-01-25
申请号：EP10709546.5
申请日：2010-03-19
申请人： LFB Biotechnologies
发明人： BEHRENS, Christian , JORIEUX, Sylvie , KHARRAT, Abdelhakim , BOUAYADI, Khalil , MONDON, Philippe , MONNET-MARS, Céline
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/92
摘要： The invention relates to a variant of a parent polypeptide comprising an Fc region, which variant exhibits increased binding to FcRn as compared to said parent polypeptide and comprises at least one amino acid modification in the Fc region.
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4.发明授权ANTICORPS ANTI-IDIOTYPIQUES NEUTRALISANT L'ACTIVITE INHIBITRICE D'UN ANTICORPS INHIBITEUR DIRIGE CONTRE LE DOMAINE C1 DU FACTEUR VIII 有权抗独特型抗体，A抑制作用AGAINST C1结构域的因子VIII抑制的效果LOOKING抗体中和的
公开(公告)号：EP1996626B1
公开(公告)日：2011-10-26
申请号：EP07731046.4
申请日：2007-02-26
申请人： LFB Biotechnologies
IPC分类号： C07K16/42 , C12N5/12 , C12N15/13 , A61K39/395 , G01N33/577 , A61P7/04
CPC分类号： C07K16/4241 , A61K2039/505
摘要： The present invention relates to an anti-idiotypic monoclonal antibody directed against a factor VIII-inhibiting antibody which binds to the C1 domain of factor VIII, and also to a cell line which produces this anti-idiotypic monoclonal antibody, to the use of this anti-idiotypic monoclonal antibody as a medicament, and more particularly to its use for the manufacture of a medicament for use in the treatment of haemophilia A.
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公开(公告)号：EP2167544A2
公开(公告)日：2010-03-31
申请号：EP07872460.6
申请日：2007-12-28
CPC分类号： C07K16/28 , C07K16/2833 , C07K2317/24 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75
摘要： The invention relates to a monoclonal antibody directed against the human LDL (Low Density Lipoprotein) receptor, in which the variable region of each of the light chains is coded by the murine nucleic acid sequence SEQ ID NO : 5, the variable region of each of the heavy chains is coded by the murine nucleic acid sequence SEQ ID NO : 7, or by nucleic acid sequences having a sufficient homology with the sequences SEQ ID NO : 5 and SEQ ID NO : 7 so that the nature and the affinity of the bond between the antibody and its antigene are not modified, while the constant regions of the light chains and the heavy chains thereof are constant regions from a non-murine species.
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6.发明公开IMMUNOGLOBULINE G CONTRE LES TOXINES DU CHARBON 有权GEGEN ANTHRAXTOXINE EINGESETZTES G-IMMUNOGLOBULIN
公开(公告)号：EP2235057A2
公开(公告)日：2010-10-06
申请号：EP08856851.4
申请日：2008-11-28
IPC分类号： C07K16/12 , C12N15/13 , A61K39/395 , A61P31/04 , A61K47/42 , G01N33/569 , C12N15/63
CPC分类号： C07K16/1278 , A61K2039/505 , A61K2039/545 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The invention relates to a G-class immunoglobulin (IgG) directed against the protective antigen (PA) of the anthrax toxin, that includes: a light-chain variable region including an amino-acid sequence that is at least 90% identical in terms of amino-acids with the sequence SEQ ID N °1 as defined in the description; and a heavy-chain variable region including an amino acid sequence that is at least 90% identical in terms of amino-acids with the sequence SEQ ID N °2 as defined in the description; characterised in that it consists of an IgG1 or an IgG2.
摘要翻译： 针对针对炭疽毒素的保护性抗原（PA）的G类（IgG）的免疫球蛋白包括：轻链可变区，其包含与序列SEQ ID号至少90％氨基酸同一性的氨基酸序列 如描述中定义的No1，以及包含与描述中定义的序列SEQ ID No2具有至少90％氨基酸同一性的氨基酸序列的重链可变区，其特征在于其由 IgG1或IgG2。
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7.发明公开ANTICORPS ANTI-IDIOTYPIQUES NEUTRALISANT L'ACTIVITE INHIBITRICE D'UN ANTICORPS INHIBITEUR DIRIGE CONTRE LE DOMAINE C1 DU FACTEUR VIII 有权抗独特型抗体，A抑制作用AGAINST C1结构域的因子VIII抑制的效果LOOKING抗体中和的
公开(公告)号：EP1996626A1
公开(公告)日：2008-12-03
申请号：EP07731046.4
申请日：2007-02-26
申请人： LFB Biotechnologies
IPC分类号： C07K16/42 , C12N5/12 , C12N15/13 , A61K39/395 , G01N33/577 , A61P7/04
CPC分类号： C07K16/4241 , A61K2039/505
摘要： The present invention relates to an anti-idiotypic monoclonal antibody directed against a factor VIII-inhibiting antibody which binds to the C1 domain of factor VIII, and also to a cell line which produces this anti-idiotypic monoclonal antibody, to the use of this anti-idiotypic monoclonal antibody as a medicament, and more particularly to its use for the manufacture of a medicament for use in the treatment of haemophilia A.
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8.发明公开ANTICORPS ANTI-IDIOTYPIGUES NEUTRALISANT L'ACTIVITE INHIBITRICE D'UN ANTICORPS INHIBITEUR DIRIGE CONTRE LE DOMAINE C1 DU FACTEUR VIII 审中-公开抗独特型抗体的C1结构域的因子VIII抑制的抑制活性抗体展望中性
公开(公告)号：EP2190881A1
公开(公告)日：2010-06-02
申请号：EP07823446.5
申请日：2007-08-23
申请人： LFB Biotechnologies
CPC分类号： C07K16/4241 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an anti-idiotypic monoclonal antibody directed against a factor VIII-inhibiting antibody which binds to the C1 domain of factor VIII, and also relates to a cell line producing this anti-idiotypic monoclonal antibody, to the use of this anti-idiotypic monoclonal antibody as a medicament, and more particularly to the use thereof for the manufacture of a medicament for the treatment of haemophilia A.
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