摘要:
The invention provides testing devices useful in colorimeteric measurements of analytes in which at least a portion of the device's support is of a reflectivity that will not interfere with the meter's error detecting means.
摘要:
A reagent strip for measuring glucose concentration in whole blood has reduced interference of hematocrit with the glucose measurement. When a biological fluid contacts the strip, it causes, in a reagent impregnated in the strip, a color change that is a measure of the glucose concentration in the fluid. However, the color change is also affected by the red blood cell concentration (hematocrit), thereby reducing the accuracy of the glucose measurement. The hematocrit effect is reduced by adding to the reagent an acrylic acid polymer.
摘要:
A reagent strip for measuring glucose concentration in whole blood has reduced interference of hematocrit with the glucose measurement. When a biological fluid contacts the strip, it causes, in a reagent impregnated in the strip, a color change that is a measure of the glucose concentration in the fluid. However, the color change is also affected by the red blood cell concentration (hematocrit), thereby reducing the accuracy of the glucose measurement. The hematocrit effect is reduced by adding to the reagent an acrylic acid polymer.
摘要:
A test strip for detecting an analyte (e.g., blood glucose) in a liquid sample (e.g., whole blood) includes an analytical portion (e.g., a reagent pad), a first edge with a first edge indentation and a second edge with a second edge indentation. The test strip also includes a first capillary channel adapted for providing fluid communication between the first edge indentation and the analytical portion, as well as a second capillary channel adapted for providing fluid communication between the second edge indentation and the analytical portion. Furthermore, the first and second edges are in an opposing relationship (e.g., on left-hand and right-hand sides of the test strip). Also, a test strip and meter combination for detecting an analyte in a liquid sample. The combination includes a test strip with an analytical portion and first and second edges. The first and second edges of the test strip each include an edge indentation with a sample application region. The test strip also includes a first capillary channel adapted for providing fluid communication between the sample application region of the first edge indentation and the analytical portion, as well as a second capillary channel adapted for providing fluid communication between the sample application region of the second edge indentation and the analytical portion. The meter includes a test strip holder configured to receive the test strip in the absence of contact between the sample application regions of the first and second edge indentations and the test strip holder.
摘要:
A chemical timer for a direct-reading reagent test strip changes color a predetermined time after a biological fluid is applied to the strip. The strip measures the concentration of an analyte in the fluid. The timer is a dry coating of an indicator, an enzyme-containing reagent that when hydrated can react with glucose to change the color of the indicator, an inhibitor to inhibit the change in color of the indicator, glucose, and optionally, an aldose that does not react with the enzyme in the reagent. Preferably, the reagent and glucose are present in excess in the coating, and the time it takes for the timer color to change can be controlled by the inhibitor concentration. The aldose provides timer stability, probably by interfering with glycosylation by the glucose in the dry state.
摘要:
A reagent test strip is adapted for use in a blood glucose meter. A sample of whole blood is applied to one surface of a matrix on the strip and the meter measures the reflectance of the opposite surface of the matrix at about 635 nm and 700 nm and calculates from the reflectance the concentration of glucose in the sample. The portion of the applied sample that penetrates the matrix and is visible from the testing surface does not absorb to any appreciable extent at 700 nm. Nevertheless, the glucose-containing sample interacts with the components of the reagent-containing matrix to cause a change in reflectance at 700 nm that simulates the effect of the blood color. As a result, the strip can be used in meters that measure glucose concentration in whole blood samples in the presence of optically visible hemoglobin.