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    GLUCOSE SENSOR CALIBRATION
    1.
    发明公开
    GLUCOSE SENSOR CALIBRATION 审中-公开
    GLUCOSESENSORKALIBRIERUNG

    公开(公告)号：EP3102106A1

    公开(公告)日：2016-12-14

    申请号：EP15704080.9

    申请日：2015-02-03

    申请人： LIGHTSHIP MEDICAL LIMITED

    发明人： CRANE, Barry Colin ,  BARWELL, Nicholas Paul ,  PATERSON, William

    IPC分类号： A61B5/1495 ,  A61B5/145 ,  A61B5/1459

    CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/1459 ,  A61B2560/0233

    摘要： A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.

    BARRIER LAYER FOR GLUCOSE SENSOR
    3.
    发明公开
    BARRIER LAYER FOR GLUCOSE SENSOR 审中-公开
    BARRIERESCHICHTFÜREINEN GLUKOSEMESSER

    公开(公告)号：EP2744909A1

    公开(公告)日：2014-06-25

    申请号：EP12761768.6

    申请日：2012-08-08

    申请人： LIGHTSHIP MEDICAL LIMITED

    发明人： CRANE, Barry ,  PATERSON, William ,  BARWELL, Nicholas Paul

    IPC分类号： C12Q1/00 ,  G01N21/77 ,  G01N27/40 ,  G01N27/404 ,  G01N21/64

    CPC分类号： G01N33/66 ,  G01N21/6428 ,  G01N21/7703 ,  G01N33/582 ,  G01N2021/6434 ,  G01N2021/772 ,  G01N2021/7786 ,  Y10T29/49

    摘要： An optical glucose sensor for detecting and/or quantifying the amount of glucose in a sample comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a glucose-permeable barrier layer comprising a semi-permeable membrane having pores and a hydrophilic polymer within the pores of the semi-permeable membrane, the barrier layer overlying at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through the glucose-permeable barrier layer, and an ROS-quenching agent is present in the sensing region and/or the glucose-permeable barrier layer.

    摘要翻译： 一种用于检测和/或定量样品中葡萄糖量的光学葡萄糖传感器，包括：包含与葡萄糖结合的硼酸受体的感测区域和与所述受体相关的荧光团; 用于将入射光引导到感测区域上的光波导; 以及葡萄糖可渗透阻隔层，其包含在所述半透膜的孔内具有孔和亲水性聚合物的半透膜，所述阻挡层覆盖所述感测区域的至少一部分; 其中所述传感器适于使得葡萄糖通过所述葡萄糖可渗透阻隔层进入所述传感器的感测区域，并且所述感测区域和/或所述葡萄糖可渗透阻挡层中存在ROS猝灭剂。

    OPTICAL GLUCOSE BIOSENSOR CALIBRATION USING DIFFERENT TEMPERATURE CALIBRATION SOLUTIONS
    6.
    发明公开
    OPTICAL GLUCOSE BIOSENSOR CALIBRATION USING DIFFERENT TEMPERATURE CALIBRATION SOLUTIONS 审中-公开
    光学葡萄糖生物传感器校准使用不同的温度校准解决方案

    公开(公告)号：EP2715369A1

    公开(公告)日：2014-04-09

    申请号：EP12729693.7

    申请日：2012-05-25

    申请人： LIGHTSHIP MEDICAL LIMITED

    发明人： BARWELL, Nicholas Paul ,  EDGLEY, Peter ,  MACKENZIE, Alasdair Allan ,  PATERSON, William ,  CRANE, Barry Colin

    IPC分类号： G01N33/58 ,  G01N33/66

    CPC分类号： G01K15/005 ,  G01N33/5438 ,  G01N33/582 ,  G01N33/66

    摘要： A method of calibrating a reversible-binding sensor for detecting an analyte includes: (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.

    摘要翻译： 校准用于检测分析物的可逆结合传感器的方法包括：（i）当第一校准溶液与第一校准溶液接触时，将第一校准溶液的温度从第一温度（T1）改变到第二温度（T2） 传感器的感测区域; （ii）确定作为温度函数的第一校准溶液的传感器输出; （iii）当所述第二校准溶液与所述感测区域接触时，将第二校准溶液的温度从第三温度（T3）改变为第四温度（T4），所述第二校准溶液具有不同的分析物浓度 从第一个校准解决方案的; （iv）根据温度确定第二校准溶液的传感器输出; 和（v）使用步骤（ii）和（iv）中确定的传感器输出来校准传感器。