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    FLUORESCENCE MEASUREMENT
    1.
    发明公开
    FLUORESCENCE MEASUREMENT 审中-公开
    FLUORESZENZMESSUNG

    公开(公告)号：EP2596336A2

    公开(公告)日：2013-05-29

    申请号：EP11704832.2

    申请日：2011-02-15

    申请人： LIGHTSHIP MEDICAL LIMITED

    发明人： CRANE, Barry Colin ,  GILCHRIST, John ,  CAIRNS, Neil

    IPC分类号： G01N21/64 ,  G01N21/77 ,  C07F5/02

    CPC分类号： G01N21/6486 ,  G01N21/6408 ,  G01N21/7703 ,  G01N33/66 ,  G01N2021/6484 ,  G01N2021/772 ,  G01N2021/7786

    摘要： A sensor for fluorescence measurement comprising: a light source arranged for emitting light to a sample region, wherein the light source intensity is modulatable; an indicator system located at the sample region, said indicator system comprising: a receptor for an analyte; and a fluorophore associated with said receptor, wherein the fluorophore has a fluorescence lifetime that changes in response to the presence of analyte at the receptor; a single photon avalanche diode arranged to receive fluorescence light emitted from said sample region in response to the light incident on the sample region from the light source, and to generate an output signal; a driver arranged to modulate the light source intensity at a first frequency; a bias voltage source arranged to apply a bias voltage to the single photon avalanche diode, wherein the bias voltage is modulated at a second frequency, different from the first frequency, and wherein the bias voltage is above the breakdown voltage of the single photon avalanche diode; and a signal processor arranged to determine information related to a fluorescence lifetime of the fluorophore based on at least the output signal of the single photon avalanche diode.

    GLUCOSE SENSOR CALIBRATION
    2.
    发明公开
    GLUCOSE SENSOR CALIBRATION 审中-公开
    GLUCOSESENSORKALIBRIERUNG

    公开(公告)号：EP3102106A1

    公开(公告)日：2016-12-14

    申请号：EP15704080.9

    申请日：2015-02-03

    申请人： LIGHTSHIP MEDICAL LIMITED

    发明人： CRANE, Barry Colin ,  BARWELL, Nicholas Paul ,  PATERSON, William

    IPC分类号： A61B5/1495 ,  A61B5/145 ,  A61B5/1459

    CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/1459 ,  A61B2560/0233

    摘要： A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.

    GLUCOSE SENSOR CALIBRATION
    6.
    发明公开
    GLUCOSE SENSOR CALIBRATION 审中-公开
    葡萄糖传感器校准

    公开(公告)号：EP2780715A1

    公开(公告)日：2014-09-24

    申请号：EP12798346.8

    申请日：2012-11-16

    申请人： Lightship Medical Limited

    发明人： CRANE, Barry Colin ,  PATERSON, William

    IPC分类号： G01N33/66 ,  A61B5/145 ,  A61B5/1495 ,  G01N27/327

    CPC分类号： G01N27/3274 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  G01N33/66

    摘要： A method of calibrating a glucose sensor, which method comprises: (a) preparing a first glucose-containing calibration solution by combining water or an aqueous solution with alpha and beta glucose, the alpha and beta glucose being provided in solid form; (b) exposing a glucose sensor to said first glucose-containing calibration solution and determining the sensor output; (c) exposing the glucose sensor to one or more further calibration solutions having different glucose concentrations from each other and from said first glucose-containing calibration solution and determining the sensor output for the or each calibration solution; and (d) determining a calibration curve from the sensor output data collected in steps (b) and (c); wherein the first glucose-containing calibration solution of step (a),and if used the or each glucose-containing calibration solution of step (c), is prepared using 25 to 50 % alpha glucose and 50 to 75 % beta glucose, and wherein the first glucose-containing calibration solution of step (a), and if used the or each glucose-containing calibration solution of step (c), is prepared by combining water or an aqueous solution with freeze-dried glucose.

    OPTICAL GLUCOSE BIOSENSOR CALIBRATION USING DIFFERENT TEMPERATURE CALIBRATION SOLUTIONS
    7.
    发明公开
    OPTICAL GLUCOSE BIOSENSOR CALIBRATION USING DIFFERENT TEMPERATURE CALIBRATION SOLUTIONS 审中-公开
    光学葡萄糖生物传感器校准使用不同的温度校准解决方案

    公开(公告)号：EP2715369A1

    公开(公告)日：2014-04-09

    申请号：EP12729693.7

    申请日：2012-05-25

    申请人： LIGHTSHIP MEDICAL LIMITED

    发明人： BARWELL, Nicholas Paul ,  EDGLEY, Peter ,  MACKENZIE, Alasdair Allan ,  PATERSON, William ,  CRANE, Barry Colin

    IPC分类号： G01N33/58 ,  G01N33/66

    CPC分类号： G01K15/005 ,  G01N33/5438 ,  G01N33/582 ,  G01N33/66

    摘要： A method of calibrating a reversible-binding sensor for detecting an analyte includes: (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.

    摘要翻译： 校准用于检测分析物的可逆结合传感器的方法包括：（i）当第一校准溶液与第一校准溶液接触时，将第一校准溶液的温度从第一温度（T1）改变到第二温度（T2） 传感器的感测区域; （ii）确定作为温度函数的第一校准溶液的传感器输出; （iii）当所述第二校准溶液与所述感测区域接触时，将第二校准溶液的温度从第三温度（T3）改变为第四温度（T4），所述第二校准溶液具有不同的分析物浓度 从第一个校准解决方案的; （iv）根据温度确定第二校准溶液的传感器输出; 和（v）使用步骤（ii）和（iv）中确定的传感器输出来校准传感器。