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公开(公告)号：EP2596336A2
公开(公告)日：2013-05-29
申请号：EP11704832.2
申请日：2011-02-15
CPC分类号： G01N21/6486 , G01N21/6408 , G01N21/7703 , G01N33/66 , G01N2021/6484 , G01N2021/772 , G01N2021/7786
摘要： A sensor for fluorescence measurement comprising: a light source arranged for emitting light to a sample region, wherein the light source intensity is modulatable; an indicator system located at the sample region, said indicator system comprising: a receptor for an analyte; and a fluorophore associated with said receptor, wherein the fluorophore has a fluorescence lifetime that changes in response to the presence of analyte at the receptor; a single photon avalanche diode arranged to receive fluorescence light emitted from said sample region in response to the light incident on the sample region from the light source, and to generate an output signal; a driver arranged to modulate the light source intensity at a first frequency; a bias voltage source arranged to apply a bias voltage to the single photon avalanche diode, wherein the bias voltage is modulated at a second frequency, different from the first frequency, and wherein the bias voltage is above the breakdown voltage of the single photon avalanche diode; and a signal processor arranged to determine information related to a fluorescence lifetime of the fluorophore based on at least the output signal of the single photon avalanche diode.
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公开(公告)号：EP2537034A1
公开(公告)日：2012-12-26
申请号：EP11704831.4
申请日：2011-02-15
发明人： CRANE, Barry , PATERSON, William , CULBERT, Bruce
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , B01D63/00 , B01L2200/027 , G01N21/7703 , G01N2021/772 , G01N2021/775 , G01N2021/7786 , Y10T29/49826
摘要： An optical glucose sensor comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a hydrophilic, polymeric, glucose-permeable barrier layer which is provided on at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through said barrier layer.
摘要翻译： 一种光学葡萄糖传感器，包括：包含用于结合葡萄糖的硼酸受体和与所述受体相关联的荧光团的感测区域; 用于将入射光引导到感测区域上的光波导; 以及设置在所述感测区域的至少一部分上的亲水性，聚合物，葡萄糖可渗透屏障层; 其中所述传感器适于使得葡萄糖通过所述阻挡层进入所述传感器的感测区域。
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公开(公告)号：EP2663570B1
公开(公告)日：2018-07-18
申请号：EP12701018.9
申请日：2012-01-10
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1455 , A61B5/1495 , C07F5/025 , G01N2400/00
摘要： The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.
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4.发明公开FLUOROPHORE AND FLUORESCENT SENSOR COMPOUND CONTAINING SAME 审中-公开FLUORPHOR UND FLUORESZENZSENSORVERBINDUNG DAMIT
公开(公告)号：EP3053914A1
公开(公告)日：2016-08-10
申请号：EP16155522.2
申请日：2010-04-08
IPC分类号： C07D221/18 , C07F5/02 , G01N33/58 , C09K11/06
CPC分类号： G01N33/582 , C07C311/39 , C07D221/18 , C09B5/14 , C09B57/001 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , G01N2400/00 , Y10T436/144444
摘要： The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety:
There is further provided a method of sensing the presence of a target analyte using the fluorescent sensor compound, as well as the use of the fluorescent sensor compounds to sense a target analyte.摘要翻译： 本发明提供式（I）和（II）的荧光团，以及包含基于这样的荧光团与受体部分组合的荧光团部分的荧光传感器化合物：还提供了一种使用荧光传感器感测目标分析物的存在的方法 化合物，以及使用荧光传感器化合物来感测目标分析物。
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公开(公告)号：EP2663570A1
公开(公告)日：2013-11-20
申请号：EP12701018.9
申请日：2012-01-10
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1455 , A61B5/1495 , C07F5/025 , G01N2400/00
摘要： The present invention provides a glucose sensor having a glucose receptor containing a binding site of formula (I): wherein X, n, m and R1 are defined herein. Also provided is a glucose sensor molecule for use in such a glucose sensor, the glucose sensor molecule containing the binding site of formula (I). The binding site has been found to have particularly good selectivity for glucose.
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公开(公告)号：EP2041562B1
公开(公告)日：2019-05-01
申请号：EP07733404.3
申请日：2007-06-28
发明人： CRANE, Barry , FRANCIS, Ian , PERKINS, Robert , PATERSON, William
IPC分类号： A61B5/145 , G01N35/00 , G01N27/327 , A61B5/1459 , A61B5/1495
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公开(公告)号：EP2537034B1
公开(公告)日：2019-01-02
申请号：EP11704831.4
申请日：2011-02-15
发明人： CRANE, Barry , PATERSON, William , CULBERT, Bruce
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公开(公告)号：EP3102106A1
公开(公告)日：2016-12-14
申请号：EP15704080.9
申请日：2015-02-03
IPC分类号： A61B5/1495 , A61B5/145 , A61B5/1459
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1459 , A61B2560/0233
摘要： A process for calibrating a glucose sensor under sterile conditions includes providing separate, sterile, glucose-containing calibration fluids, each having a different glucose concentration, and in turn providing these fluids to a sensing zone containing a sensing probe of a glucose sensor. Each solution is typically, in turn, propelled into the sensing zone, thus flushing out used fluid already present in the sensing zone. The process provides rapid calibration of a glucose sensor in a sterile fashion and is therefore appropriate for point-of-use calibration.
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9.发明公开SENSOR FOR DETECTING THE AMOUNT OF ANALYTE IN A SAMPLE 审中-公开SENSOR ZUR ERFASSUNG DER MENGE EINES ANALYTEN IN EINER PROBE
公开(公告)号：EP2825095A2
公开(公告)日：2015-01-21
申请号：EP13707903.4
申请日：2013-02-20
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/14735 , G01N21/6428 , G01N21/7703 , G01N33/542 , G01N33/54366 , G01N33/84 , Y10T436/144444 , Y10T436/206664 , Y10T436/255
摘要： A sensor for detecting and/or quantifying the amount of analyte in a sample, the sensor including: a sensing region; and a barrier layer including a reactive oxygen species (ROS)-quenching, analyte-permeable membrane having an ROS-quenching agent adsorbed to the membrane; wherein the sensor is adapted so that the sample enters the sensing region of the sensor through the barrier layer.
摘要翻译： 一种用于检测和/或定量样品中分析物的量的传感器，所述传感器包括：感测区域; 以及包含活性氧（ROS）淬火的阻隔层，具有吸附在膜上的ROS猝灭剂的分析物可渗透膜; 其中所述传感器适于使得所述样品通过所述阻挡层进入所述传感器的感测区域。
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公开(公告)号：EP2715369B1
公开(公告)日：2018-11-21
申请号：EP12729693.7
申请日：2012-05-25
发明人： BARWELL, Nicholas Paul , EDGLEY, Peter , MACKENZIE, Alasdair Allan , PATERSON, William , CRANE, Barry Colin
CPC分类号： G01K15/005 , G01N33/5438 , G01N33/582 , G01N33/66
摘要： A method of calibrating a reversible-binding sensor for detecting an analyte includes: (i) varying the temperature of a first calibration solution from a first temperature (T1) to a second temperature (T2) while the first calibration solution is in contact with a sensing region of the sensor; (ii) determining the sensor output for the first calibration solution as a function of temperature; (iii) varying the temperature of a second calibration solution from a third temperature (T3) to a fourth temperature (T4) while the second calibration solution is in contact with the sensing region, the second calibration solution having a concentration of analyte which is different from that of the first calibration solution; (iv) determining the sensor output for the second calibration solution as a function of temperature; and (v) using the determined sensor output from steps (ii) and (iv) to calibrate the sensor.
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