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公开(公告)号：EP3027650A1
公开(公告)日：2016-06-08
申请号：EP14748185.7
申请日：2014-08-01
发明人： LUCAS, Sophie , COULIE, Pierre , CUENDE VILLASUR, Julia , DUMOUTIER, Laure , RENAULD, Jean-Christophe , VAN DE WONING, Sebastian , SAUNDERS, Michael , DE HAARD, Hans , DE BOECK, Gitte
CPC分类号： C07K16/2875 , A61K2039/505 , C07K16/28 , C07K16/30 , C07K2317/22 , C07K2317/24 , C07K2317/31 , C07K2317/32 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to an antibody binding to the transmembrane protein ‘glycoprotein A repetitions predominant’ (GARP) in the presence of TGF-β and uses thereof.
摘要翻译： 本发明涉及在TGF-β存在下与跨膜蛋白“重复占优势”（GARP）结合的抗体及其用途。
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公开(公告)号：EP1527178A2
公开(公告)日：2005-05-04
申请号：EP02756665.2
申请日：2002-07-24
CPC分类号： G01N33/5011 , C07K14/54 , C07K14/7155 , G01N33/5008 , G01N33/5044 , G01N33/566 , G01N2333/715 , G01N2500/02 , G01N2500/20
摘要： A new class II cytokine receptor has been identified, which comprises an interleukin-22 receptor molecule, and an interleukin-20 receptor β molecule. The complex binds to cytokines homologous to IL-10, including mda-7 and IL-20. Also described are methods for inhibiting effect of interleukin-20, mda-7, and IL-19 on cells. The latter is especially useful in treatment of, e.g., skin diseases such as psoriasis.
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3.发明公开ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE A SOLUBLE IL-TIF/IL-22 RECEPTOR OR BINDING PROTEIN WHICH BINDS TO IL-TIF/IL-22 AND USES THEREOF 审中-公开分离的核酸分子可溶性IL-TIF / IL-22受体结合蛋白或WHAT TO IL-TIF / IL-22 TIES，CODE
公开(公告)号：EP1320605A2
公开(公告)日：2003-06-25
申请号：EP01973326.0
申请日：2001-09-21
IPC分类号： C12N15/12 , C12N5/10 , C12N5/20 , C12Q1/68 , C07K14/715 , C07K16/18 , G01N33/68 , G01N33/53 , A61K38/17
CPC分类号： C07K14/7155 , A01K2217/05 , A61K38/00 , C07K2319/30
摘要： The invention relates to soluble proteins which bind to the molecule known as IL-TIF/IL-22. The proteins can antagonize the effect of IL-TIF/IL-22 on target cells. The nucleic acid molecules encoding the proteins, and uses of the protein, are also described.
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4.发明公开ISOLATED NUCLEIC ACID MOLECULES WHICH ENCODE T CELL INDUCIBLE FACTORS (TIFs), THE PROTEINS ENCODED, AND USES THEREOF 有权分离的核酸分子中的T细胞诱导因子CODE（TIF），CODED蛋白及其应用
公开(公告)号：EP1131333A1
公开(公告)日：2001-09-12
申请号：EP99953231.0
申请日：1999-10-18
CPC分类号： C07K14/52
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors.
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5.发明公开
公开(公告)号：EP3786187A1
公开(公告)日：2021-03-03
申请号：EP20201515.2
申请日：2014-08-01
发明人： LUCAS, Sophie , COULIE, Pierre , CUENDE VILLASUR, Julia , DUMOUTIER, Laure , RENAULD, Jean-Christophe , VAN DER WONING, Sebastian , SAUNDERS, Michael , DE HAARD, Hans , DE BOECK, Gitte
摘要： The present invention relates to a protein binding to GARP in the presence of TGF-β and uses thereof.
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公开(公告)号：EP1537211A2
公开(公告)日：2005-06-08
申请号：EP02791396.1
申请日：2002-12-09
发明人： RENAULD, Jean-Christophe , FICKENSICHER, H.,Inst. f. Klinische u. Molekulare , DUMOUTIER, Laure , HOR, S.,Inst. f. Klinische und Molekulare
IPC分类号： C12N15/12 , C12N5/10 , C12P21/02 , C07K14/47 , C07K14/705
CPC分类号： C07K14/715 , A61K38/00
摘要： The invention relates to new members of the Class II cytokine receptor family, such as LICR-2. The new member binds to AK155, and mediates STAT activation.
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7.发明公开
公开(公告)号：EP1305419A2
公开(公告)日：2003-05-02
申请号：EP01952260.6
申请日：2001-06-27
CPC分类号： G01N33/6869 , A61K38/00 , C07K14/54 , G01N33/505
摘要： The invention involves isolation of nucleic acid molecules, the expression of which are upregulated by interleukin-9. The amino acid sequences of the proteins which correspond to the nucleic acid molecules show some structural features of cytokines. In addition to the nucleic acid molecules and the proteins, various uses of the molecules are disclosed. The molecules are referred to as T cell inducible factors. The molecules are implicated in activation of STAT molecules, acute phase proteins, and inflammation.
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