公开(公告)号：EP4404961A1

公开(公告)日：2024-07-31

申请号：EP22869532.6

申请日：2022-09-20

申请人： Laboratorio Avi-Mex, S.A. De C.V. ,  Consejo Nacional De Humanidades, Ciencias Y Tecnologías ,  Icahn School of Medicine at Mount Sinai

发明人： LOZANO DUBERNARD, Bernardo ,  SOTO PRIANTE, Ernesto ,  SARFATI MIZRAHI, David ,  CHAGOYA CORTES, Hector Elias ,  LOPEZ MACIAS, Constantino III Roberto ,  PALESE, Peter ,  GARCIA-SASTRE, Adolfo ,  KRAMMER, Florian ,  SUN, Weina ,  TORRES ROJAS, Martha

IPC分类号： A61K39/215 ,  A61K31/51 ,  A61K39/17 ,  C12N7/01 ,  C12N15/50 ,  C12N15/86

CPC分类号： C12N15/86 ,  C07K14/005 ,  C12N2770/2002220130101 ,  C12N2770/2003420130101 ,  C12N2760/1814320130101 ,  A61K39/12 ,  A61K2039/57220130101 ,  A61K2039/57520130101

公开(公告)号：EP4151232A1

公开(公告)日：2023-03-22

申请号：EP21804807.2

申请日：2021-02-22

申请人： Laboratorio Avi-Mex, S.A. De C.V. ,  Icahn School of Medicine at Mount Sinai

发明人： LOZANO-DUBERNARD, Bernardo ,  SOTO-PRIANTE, Ernesto ,  SARFATI-MIZRAHI, David ,  CASTRO-PERALTA, Felipa ,  PAZ-DE LA ROSA, Georgina ,  PALESE, Peter ,  GARCIA-SASTRE, Adolfo ,  KRAMMER, Florian ,  SUN, Weina

IPC分类号： A61K39/215 ,  C12N15/86 ,  A61P31/14

摘要： An active or inactivated recombinant vaccine against COVID-19 is described that comprises a Newcastle disease viral vector and a pharmaceutically acceptable carrier, adjuvant and/or excipient, characterized in that the viral vector is a virus capable of generating a cellular immune response that has a SARS-CoV-2 exogenous nucleotide sequence inserted.

公开(公告)号：EP4146674A2

公开(公告)日：2023-03-15

申请号：EP21800838.1

申请日：2021-05-06

申请人： Icahn School of Medicine at Mount Sinai

发明人： SUN, Weina ,  KRAMMER, Florian ,  GARCIA-SASTRE, Adolfo ,  PALESE, Peter

IPC分类号： C07K14/165 ,  C07K14/005

公开(公告)号：EP2536425B1

公开(公告)日：2019-06-19

申请号：EP11745345.6

申请日：2011-02-18

申请人： Icahn School of Medicine at Mount Sinai

发明人： GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  WANG, Taia, T. ,  TAN, Gene, S.

IPC分类号： A61K38/16 ,  A61K38/00 ,  A61K39/12 ,  C07K14/005 ,  C07K14/11 ,  A61K39/00

公开(公告)号：EP3471767A1

公开(公告)日：2019-04-24

申请号：EP17813990.3

申请日：2017-06-14

申请人： Icahn School of Medicine at Mount Sinai

发明人： PALESE, Peter ,  GARCIA-SASTRE, Adolfo ,  KRAMMER, Florian ,  ERMLER, Megan

IPC分类号： A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N7/00

公开(公告)号：EP2987856B1

公开(公告)日：2018-07-25

申请号：EP15162322.0

申请日：2010-02-05

申请人： Icahn School of Medicine at Mount Sinai ,  Memorial Sloan Kettering Cancer Center

发明人： ZAMARIN, Dmitriy ,  GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  FONG, Yuman

IPC分类号： C12N7/00 ,  A61K35/76 ,  C07K14/125 ,  C07K14/11

CPC分类号： C12N7/00 ,  A61K35/13 ,  A61K39/0011 ,  A61K39/17 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/18121 ,  C12N2760/18122 ,  C12N2760/18132 ,  C12N2760/18143 ,  C12N2760/18171

摘要： The invention provides chimeric Newcastle disease viruses (NDV) engineered to express a heterologous interferon antagonist, a modified F protein, and a cytokine. Further provided are pharmaceutical compositions comprising such chimeric viruses, methods for producing said pharmaceutical compositions and their use in a method for treating cancer in a subject. Provided are also cells and non-human embryonated eggs comprising the chimeric NDV viruses of the invention.

公开(公告)号：EP3959216A1

公开(公告)日：2022-03-02

申请号：EP20796161.6

申请日：2020-04-23

申请人： Icahn School of Medicine at Mount Sinai

发明人： KRAMMER, Florian ,  WOHLBOLD, Teddy, John ,  GARCIA-SASTRE, Adolfo ,  PALESE, Peter

IPC分类号： C07F5/02

公开(公告)号：EP3900740A1

公开(公告)日：2021-10-27

申请号：EP21153235.3

申请日：2011-03-30

申请人： Icahn School of Medicine at Mount Sinai

发明人： GARCIA-SASTRE, Adolfo ,  LOWEN, Anice C. ,  PALESE, Peter ,  STEEL, John

IPC分类号： A61K39/145 ,  A61P31/16 ,  C07K14/11

摘要： The invention provides hemagglutinin stem domain polypeptides, nucleic acids encoding the same, host cells expressing the same and viruses comprising the same. The invention also provides a viral-like particle comprising the polypeptides of the invention. The invention further provides immunogenic compositions comprising the polypeptides, viruses or viral-like particles of the invention. The invention also provides immunogenic compositions for use in immunizing a subject against influenza virus, and for use in preventing and treating an influenza virus infection or disease.

公开(公告)号：EP3820492A1

公开(公告)日：2021-05-19

申请号：EP19834094.5

申请日：2019-07-12

申请人： Icahn School of Medicine at Mount Sinai

发明人： GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  CUADRADO, CASTAÑO, Sara

IPC分类号： A61K35/768 ,  C07K14/005 ,  C12N7/00

公开(公告)号：EP3810634A1

公开(公告)日：2021-04-28

申请号：EP19821724.2

申请日：2019-06-20

申请人： Icahn School of Medicine at Mount Sinai

发明人： GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  KRAMMER, Florian ,  BRÖCKER, Felix ,  SUN, Weina

IPC分类号： C07K14/005 ,  A61K39/145 ,  C12N15/63