公开(公告)号：EP1409486A1

公开(公告)日：2004-04-21

申请号：EP02767534.7

申请日：2002-06-28

申请人： LES LABORATOIRES SERVIER

发明人： PRUDHOMME, Michelle ,  MARMINON, Christelle ,  ROUTIER, Sylvain ,  COUDERT, Gérard ,  MEROUR, Jean-Yves ,  HICKMAN, John ,  PIERRE, Alain ,  RENARD, Pierre ,  PFEIFFER, Bruno

IPC分类号： C07D471/22 ,  C07D498/22 ,  A61K31/44

CPC分类号： C07H15/252

摘要： Compounds of formula (I) wherein: WI and W2 represent, with the carbon atoms to which they are bound, a phenyl group or a pyridinyl group, and at least one of the groups W1 or W2 represent a pyridinyl group; R1 and R2 each represent a group of formula U-V as defined in the description, X and X1 each represent a hydrogen atom, a hydroxy, alkoxy, mercapto or alkylthio group; Y and Y1 each represent a hydrogen atom; or X and Y, X1 and Y1 represent, together with the carbon atom that they include, a carbonyl or thiocarbonyl group; R4 and R5 are as defined in the description; Q1, Q2 represent a hydrogen atom, or Q1 and Q2, together with the carbon atoms that they include, form an aromatic link. The inventive compounds are used in medicaments.

公开(公告)号：EP1556387A1

公开(公告)日：2005-07-27

申请号：EP03809362.1

申请日：2003-10-17

申请人： Les Laboratoires Servier

发明人： COUDERT, Gérard ,  LEPIFRE, Franck ,  CAIGNARD, Daniel-Henri ,  RENARD, Pierre ,  HICKMAN, John ,  PIERRE, Alain ,  KRAUS-BERTHIER, Laurence

IPC分类号： C07D498/04 ,  A61K31/535 ,  C07D498/14 ,  C07D265/38

CPC分类号： C07D497/04 ,  C07D497/14

摘要： The invention concerns compounds of formula (I), wherein: W1 represents with the carbon atoms whereto it is bound, a phenyl group or a pyridinyl group; Z represents a group selected among a hydrogen atom, halogen, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 arylalkyl, aryloxy, linear or branched C1-C6 arylalkoxy, hydroxy, linear or branched C1-C6 alkoxy group; R1 is such as defined in the description; R2 represents a hydrogen atom or a group of formula -CH2CH2O-R8; R3, R4 represent each a hydrogen atom, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 aryalkyl group; n represents an integer between 1 and 6 inclusive. The invention is useful for preparing medicines.

公开(公告)号：EP1587810A1

公开(公告)日：2005-10-26

申请号：EP03809363.9

申请日：2003-10-17

申请人： Les Laboratoires Servier

发明人： COUDERT, Gérard ,  AYERBE, Nathalie ,  LEPIFRE, Franck ,  ROUTIER, Sylvain ,  CAIGNARD, Daniel-Henri ,  RENARD, Pierre ,  HICKMAN, John ,  PIERRE, Alain ,  LEONCE, Stéphane

IPC分类号： C07D498/14 ,  C07D498/22 ,  C07D491/14 ,  C07D487/04 ,  A61P35/00 ,  A61K31/5365

CPC分类号： C07D471/14 ,  C07D487/04 ,  C07D491/14

摘要： The invention concerns compounds of formula (I), wherein: A is such as described in the description; Y represents a group selected among an oxygen atom or a methylene group; R2 represents a hydrogen atom, in which case: R3 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or SO2CF3, or R2 and R3 form a bond; R1 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or a linear or branched C1-C6 alkylene chain; Z1 and Z2 represent each a hydrogen atom or Z1 and Z2 form together, with the carbon atoms bearing them, a phenyl group. The invention is useful for preparing medicines.

公开(公告)号：EP1556387B1

公开(公告)日：2007-04-04

申请号：EP03809362.1

申请日：2003-10-17

申请人： Les Laboratoires Servier

发明人： COUDERT, Gérard ,  LEPIFRE, Franck ,  CAIGNARD, Daniel-Henri ,  RENARD, Pierre ,  HICKMAN, John ,  PIERRE, Alain ,  KRAUS-BERTHIER, Laurence

IPC分类号： C07D498/04 ,  A61K31/535 ,  C07D498/14 ,  C07D265/38

CPC分类号： C07D497/04 ,  C07D497/14

摘要： The invention concerns compounds of formula (I), wherein: W1 represents with the carbon atoms whereto it is bound, a phenyl group or a pyridinyl group; Z represents a group selected among a hydrogen atom, halogen, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 arylalkyl, aryloxy, linear or branched C1-C6 arylalkoxy, hydroxy, linear or branched C1-C6 alkoxy group; R1 is such as defined in the description; R2 represents a hydrogen atom or a group of formula -CH2CH2O-R8; R3, R4 represent each a hydrogen atom, a linear or branched C1-C6 alkyl, aryl, linear or branched C1-C6 aryalkyl group; n represents an integer between 1 and 6 inclusive. The invention is useful for preparing medicines.

公开(公告)号：EP1587810B1

公开(公告)日：2006-11-08

申请号：EP03809363.9

申请日：2003-10-17

申请人： Les Laboratoires Servier

发明人： COUDERT, Gérard ,  AYERBE, Nathalie ,  LEPIFRE, Franck ,  ROUTIER, Sylvain ,  CAIGNARD, Daniel-Henri ,  RENARD, Pierre ,  HICKMAN, John ,  PIERRE, Alain ,  LEONCE, Stéphane

IPC分类号： C07D498/14 ,  C07D498/22 ,  C07D491/14 ,  C07D487/04 ,  A61P35/00 ,  A61K31/5365

CPC分类号： C07D471/14 ,  C07D487/04 ,  C07D491/14

摘要： The invention concerns compounds of formula (I), wherein: A is such as described in the description; Y represents a group selected among an oxygen atom or a methylene group; R2 represents a hydrogen atom, in which case: R3 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or SO2CF3, or R2 and R3 form a bond; R1 represents a group selected among a hydrogen atom, a C1-C6 linear or branched alkyl, aryl, linear or branched C1-C6 arylalkyl group, or a linear or branched C1-C6 alkylene chain; Z1 and Z2 represent each a hydrogen atom or Z1 and Z2 form together, with the carbon atoms bearing them, a phenyl group. The invention is useful for preparing medicines.