公开(公告)号：EP1491144A1

公开(公告)日：2004-12-29

申请号：EP04253352.1

申请日：2004-06-04

申请人： LIFESCAN, INC.

发明人： Racchini, Joel ,  Hilgers, Michael ,  Stout, Phil ,  Rademacher, Thomas ,  Mechelke, Joel ,  Hanson, Cass A.

IPC分类号： A61B5/15 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/002 ,  A61B5/022 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150824 ,  A61B5/15087 ,  A61B5/15117 ,  A61B5/15144 ,  A61B5/157 ,  A61B5/6824 ,  A61B2560/0431 ,  A61B2562/0295

摘要： A system for extracting a bodily fluid sample (e.g., an interstitial fluid [ISF] sample) and monitoring an analyte therein includes a disposable cartridge and a local controller module. The disposable cartridge includes a sampling module adapted to extract a bodily fluid sample and an analysis module adapted to measure an analyte (e.g., glucose) in the bodily fluid sample. The local controller module is in electronic communication with the disposable cartridge and is adapted to receive and store measurement data from the analysis module. An ISF extraction device includes a penetration member configured for penetrating and residing in a target site of a user's skin layer and, subsequently, extracting an ISF sample therefrom. The device also includes a pressure ring(s) adapted for applying pressure to the user's skin layer in the vicinity of the target site. The device is configured such that the pressure ring(s) is capable of applying pressure in an oscillating manner whereby an ISF glucose lag of the ISF sample extracted by the penetration member is mitigated. A method for extracting ISF includes providing an ISF fluid extraction device with a penetration member and a pressure ring(s). Next, a user's skin layer is contacted by the pressure ring(s) and penetrated by the penetration member. An ISF sample is then extracted from the user's skin layer while pressure is being applied in an oscillating manner by the pressure ring(s). The oscillating pressure mitigates an ISF glucose lag of the extracted ISF sample extracted.

公开(公告)号：EP1752097A1

公开(公告)日：2007-02-14

申请号：EP06254209.7

申请日：2006-08-10

申请人： LifeScan, Inc.

发明人： Mechelke, Joel ,  Rademacher, Thomas C. ,  Hilgers, Michael Edward ,  Stout, Phil

IPC分类号： A61B5/151

CPC分类号： A61B5/1519 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150114 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117 ,  A61B10/0045 ,  A61B2010/008

摘要： A method for extracting interstitial fluid from a target site of a user includes adhesively attaching a floating ring of a sampling module for extracting interstitial fluid to the user in the vicinity of a target site and then mounting the sampling module to the floating ring and attaching the sampling module to the user. Subsequently, the target site is penetrated with a penetration member of the sampling module. Pressure is then applied in another vicinity of the target site by a pressure ring of the sampling module and, thereafter, ISF extracted from the target site via a penetration member of the sampling module.

摘要翻译： 从用户的目标部位提取组织液的方法包括将用于在目标部位附近的使用者提取组织液的取样模块的浮环粘附，然后将取样模块安装在浮环上， 采样模块给用户。 随后，用采样模块的穿透部件穿透目标部位。 然后通过采样模块的压力环将压力施加在目标位置的另一个附近，然后通过采样模块的穿透构件从目标位置提取ISF。

公开(公告)号：EP1752096A2

公开(公告)日：2007-02-14

申请号：EP06254203.0

申请日：2006-08-10

申请人： LifeScan, Inc.

发明人： Mechelke, Joel ,  Rademacher, Thomas C. ,  Hilgers, Michael Edward ,  Stout, Phil

IPC分类号： A61B5/15 ,  A61B10/00

CPC分类号： A61B5/1519 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150114 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117 ,  A61B10/0045 ,  A61B2010/008

摘要： A sampling module for extracting interstitial fluid (ISF) from a user's body includes a housing assembly and a pressure ring assembly operatively contained within the housing assembly. The pressure ring assembly includes a penetration member configured for penetrating a target site of the user's body and, subsequently, residing in the target site and extracting ISF therefrom. The pressure ring assembly also includes a pressure ring configured for applying pressure to the user's body in a first vicinity of the target site and a floating ring with an adhesive layer disposed on it's distal end. The adhesive layer of the sampling module provides for adhesive attachment of the floating ring to the user's body in a second vicinity of the target site, thereby influencing target site deformation during use of the sampling module.

摘要翻译： 用于从使用者身体提取组织液（ISF）的采样模块包括壳体组件和可操作地容纳在壳体组件内的压力环组件。 所述压力环组件包括穿透构件，所述穿透构件被构造用于穿透使用者身体的目标部位，并且随后驻留在所述目标部位并从其中提取ISF。 压力环组件还包括压力环，该压力环被配置为在目标位置的第一附近向使用者的身体施加压力，以及具有设置在其远端上的粘合剂层的浮动环。 采样模块的粘合剂层在目标位置的第二附近提供浮动环粘合到使用者的身体上，从而在采样模块的使用期间影响目标位置的变形。

公开(公告)号：EP1752096A3

公开(公告)日：2007-03-21

申请号：EP06254203.0

申请日：2006-08-10

申请人： LifeScan, Inc.

发明人： Mechelke, Joel ,  Rademacher, Thomas C. ,  Hilgers, Michael Edward ,  Stout, Phil

IPC分类号： A61B5/151 ,  A61B10/00

CPC分类号： A61B5/1519 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150114 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/15107 ,  A61B5/15117 ,  A61B10/0045 ,  A61B2010/008

摘要： A sampling module for extracting interstitial fluid (ISF) from a user's body includes a housing assembly and a pressure ring assembly operatively contained within the housing assembly. The pressure ring assembly includes a penetration member configured for penetrating a target site of the user's body and, subsequently, residing in the target site and extracting ISF therefrom. The pressure ring assembly also includes a pressure ring configured for applying pressure to the user's body in a first vicinity of the target site and a floating ring with an adhesive layer disposed on it's distal end. The adhesive layer of the sampling module provides for adhesive attachment of the floating ring to the user's body in a second vicinity of the target site, thereby influencing target site deformation during use of the sampling module.

公开(公告)号：EP1510171A1

公开(公告)日：2005-03-02

申请号：EP04255207.5

申请日：2004-08-27

申请人： LIFESCAN, INC.

发明人： Stout, Phil ,  Melander, Todd

IPC分类号： A61B5/00 ,  A61B5/15

CPC分类号： A61B5/0002 ,  A61B5/022 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  A61B5/6824 ,  A61B2560/0431 ,  A61B2562/0295 ,  Y10T436/11

摘要： An analytical device for predicting a subject's whole blood analyte concentration based on the subject's interstitial fluid (ISF) analyte concentration includes an ISF sampling module, an analysis module and a prediction module. The ISF sampling module is configured to sequentially extract a plurality of ISF samples from a subject. The analysis module is configured to sequentially determining an ISF analyte concentration (e.g., ISF glucose concentration) in each of the ISF samples, resulting in a series of ISF analyte concentrations. The prediction module is configured for storing the series of ISF analyte concentrations and predicting the subject's whole blood analyte concentration based on the series by performing at least one algorithm. A method for predicting a subject's whole blood analyte concentration based on the subject's interstitial fluid analyte concentration includes extracting a plurality of interstitial fluid (ISF) samples from a subject in a sequential manner and sequentially determining an ISF analyte concentration in each of the plurality of ISF samples to create a series of ISF analyte concentrations. The subject's blood analyte concentration is then predicted based on the series of ISF analyte concentrations by performing at least one algorithm.

摘要翻译： 基于受试者的间质液（ISF）分析物浓度来预测受试者的全血分析物浓度的分析装置包括ISF采样模块，分析模块和预测模块。 ISF采样模块被配置为从对象顺序地提取多个ISF样本。 分析模块被配置为依次确定每个ISF样品中的ISF分析物浓度（例如，ISF葡萄糖浓度），得到一系列ISF分析物浓度。 预测模块被配置为存储一系列ISF分析物浓度，并且通过执行至少一种算法来基于该系列预测受试者的全血分析物浓度。 基于受试者的间质液分析物浓度来预测受试者的全血分析物浓度的方法包括以顺序方式从受试者中提取多个间质液样品，并依次确定多个ISF中的每一个的ISF分析物浓度 样品产生一系列ISF分析物浓度。 然后通过执行至少一种算法，基于ISF分析物浓度的一系列来预测受试者的血液分析物浓度。