公开(公告)号：EP2678327B9

公开(公告)日：2016-12-28

申请号：EP12709965.3

申请日：2012-02-22

申请人： Lupin Limited

发明人： SINHA, Neelima ,  JANA, Gourhari ,  SACHCHIDANAND, Sachchidanand ,  KURHADE, Sanjay, Pralhad ,  KARCHE, Navnath, Popat ,  HAJARE, Anil, Kashiram ,  TILEKAR, Ajay, Ramchandra ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D333/22 ,  C07D409/04 ,  A61K31/381 ,  A61P25/28

CPC分类号： A61K31/5377 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/496 ,  A61K45/06 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D307/68 ,  C07D333/22 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38 ,  C07D409/04 ,  A61K2300/00

公开(公告)号：EP2678327B8

公开(公告)日：2016-09-28

申请号：EP12709965.3

申请日：2012-02-22

申请人： Lupin Limited

发明人： SINHA, Neelima ,  JANA, Gourhari ,  SACHCHIDANAND, Sachchidanand ,  KURHADE, Sanjay, Pralhad ,  KARCHE, Navnath, Popat ,  HAJARE, Anil, Kashiram ,  TILEKAR, Ajay, Ramchandra ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D333/22 ,  C07D409/04 ,  A61K31/381 ,  A61P25/28

CPC分类号： A61K31/5377 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/496 ,  A61K45/06 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D307/68 ,  C07D333/22 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38 ,  C07D409/04 ,  A61K2300/00

公开(公告)号：EP2678327B1

公开(公告)日：2016-08-17

申请号：EP12709965.3

申请日：2012-02-22

申请人： Lupin Limited

发明人： SINHA, Neelima ,  JANA, Gourhari ,  SACHCHIDANAND, Sachchidanand ,  KURHADE, Sanjay, Pralhad ,  KARCHE, Navnath, Popat ,  HAJARE, Anil, Kashiram ,  TILEKAR, Ajay, Ramchandra ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D333/22 ,  C07D409/04 ,  A61K31/381 ,  A61P25/28

CPC分类号： A61K31/5377 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/496 ,  A61K45/06 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D307/68 ,  C07D333/22 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38 ,  C07D409/04 ,  A61K2300/00

公开(公告)号：EP2870140B1

公开(公告)日：2016-07-27

申请号：EP13742752.2

申请日：2013-07-09

申请人： Lupin Limited

发明人： JANA, Gourhari ,  KURHADE, Sanjay, Pralhad ,  JAGDALE, Arun, Rangnath ,  KUKREJA, Gagan ,  SINHA, Neelima ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D239/90 ,  C07D239/88 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D487/08 ,  A61K31/517 ,  A61K31/527 ,  A61K45/06 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D401/12

公开(公告)号：EP3337802A1

公开(公告)日：2018-06-27

申请号：EP16763958.2

申请日：2016-08-13

申请人： Lupin Limited

发明人： KARCHE, Navnath, Popat ,  TILEKAR, Ajay, Ramchandra ,  KURHADE, Sanjay, Pralhad ,  JADHAV, Ganesh, Rajaram ,  GUPTA, Nishant, Ramniwasji ,  SINHA, Neelima ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D471/04 ,  A61K31/4365 ,  A61K31/4375 ,  C07D495/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61K31/196 ,  A61K31/198 ,  A61K31/255 ,  A61K31/337 ,  A61K31/454 ,  A61K31/475 ,  A61K31/495 ,  A61K31/497 ,  A61K31/498 ,  A61K31/517 ,  A61K31/675 ,  C07D495/04 ,  A61K2300/00

摘要： Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein ring Ar, ring B, R1-R5, X, Y, p, q, r, and s are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject.

公开(公告)号：EP2870140B8

公开(公告)日：2016-09-28

申请号：EP13742752.2

申请日：2013-07-09

申请人： Lupin Limited

发明人： JANA, Gourhari ,  KURHADE, Sanjay, Pralhad ,  JAGDALE, Arun, Rangnath ,  KUKREJA, Gagan ,  SINHA, Neelima ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D239/90 ,  C07D239/88 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D487/08 ,  A61K31/517 ,  A61K31/527 ,  A61K45/06 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D401/12

公开(公告)号：EP4081521A1

公开(公告)日：2022-11-02

申请号：EP20842043.0

申请日：2020-12-27

申请人： Lupin Limited

发明人： KURHADE, Sanjay, Pralhad ,  NAIR, Prathap, Sreedharan ,  SETHI, Sachin ,  SHUKLA, Manojkumar, Ramprasad ,  SINDKHEDKAR, Milind, Dattatraya ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar ,  PHUKAN, Samiron ,  PATIL, Pradeep, Rangrao ,  MAJID, Sayyed ,  PHADATARE, Ramesh ,  WALKE, Navnath ,  PACHPUTE, Vipul ,  GORE, Balasaheb ,  TAMBE, Vikas ,  LIMAYE, Rohan ,  BHOSALE, Avadhut ,  MAHANGARE, Sachin

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D491/107 ,  C07D498/04 ,  A61P35/00 ,  A61K31/519

公开(公告)号：EP2870140A1

公开(公告)日：2015-05-13

申请号：EP13742752.2

申请日：2013-07-09

申请人： Lupin Limited

发明人： JANA, Gourhari ,  KURHADE, Sanjay, Pralhad ,  JAGDALE, Arun, Rangnath ,  KUKREJA, Gagan ,  SINHA, Neelima ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D239/90 ,  C07D239/88 ,  A61K31/517 ,  A61P35/00

CPC分类号： C07D487/08 ,  A61K31/517 ,  A61K31/527 ,  A61K45/06 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D401/12

摘要： Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R
1 -R
6 , R
7a-d , R
8a-d , A, M, n, and p are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject.

公开(公告)号：EP2678327A1

公开(公告)日：2014-01-01

申请号：EP12709965.3

申请日：2012-02-22

申请人： Lupin Limited

发明人： SINHA, Neelima ,  JANA, Gourhari ,  SACHCHIDANAND, Sachchidanand ,  KURHADE, Sanjay, Pralhad ,  KARCHE, Navnath, Popat ,  HAJARE, Anil, Kashiram ,  TILEKAR, Ajay, Ramchandra ,  PALLE, Venkata, P. ,  KAMBOJ, Rajender, Kumar

IPC分类号： C07D333/22 ,  C07D409/04 ,  A61K31/381 ,  A61P25/28

CPC分类号： A61K31/5377 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4436 ,  A61K31/4535 ,  A61K31/496 ,  A61K45/06 ,  C07D207/32 ,  C07D207/333 ,  C07D207/337 ,  C07D307/68 ,  C07D333/22 ,  C07D333/26 ,  C07D333/36 ,  C07D333/38 ,  C07D409/04 ,  A61K2300/00

摘要： Disclosed is a compound of formula (I), wherein Z, m and R
1 -R
6 are as described herein, as a modulator of nicotinic acetylcholine receptors particularly the α7 subtype, in a subject in need thereof, as well as analogues, prodrugs, isotopically substituted analogs, metabolites, pharmaceutically acceptable salts, polymorphs, solvates, isomers, clathrates, and co-crystal thereofs, for use either alone or in combinations with suitable other medicaments, and pharmaceutical compositions containing such compounds and analogues. Also disclosed are a process of preparation of the compounds and the intended uses thereof in therapy, particularly in the prophylaxis and therapy of disorders such as Alzheimer's disease, mild cognitive impairment, senile dementia, and the like.