公开(公告)号：EP3821818A2

公开(公告)日：2021-05-19

申请号：EP20199089.2

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B17/00 ,  A61B18/24 ,  A61F2/00 ,  A61B17/12 ,  A61B18/00 ,  A61B18/22

摘要： An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect ( e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.

公开(公告)号：EP4232012A1

公开(公告)日：2023-08-30

申请号：EP21884062.7

申请日：2021-10-25

申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

发明人： MEAD, Benjamin ,  SHALEK, Alexander, K. ,  KARP, Jeffrey ,  HATTORI, Kazuki

IPC分类号： A61K31/015 ,  A61K31/047 ,  A61K31/706 ,  A61K31/7068 ,  C12N5/071 ,  C12N5/074

公开(公告)号：EP3821818A3

公开(公告)日：2021-07-21

申请号：EP20199089.2

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B17/00 ,  A61B18/24 ,  A61F2/00 ,  A61B17/12 ,  A61B18/00 ,  A61B18/22

摘要： An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect ( e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.

公开(公告)号：EP3142586B1

公开(公告)日：2020-09-30

申请号：EP15792211.3

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute Of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B18/24 ,  A61B18/22 ,  A61B17/12 ,  A61M25/10 ,  A61M25/00 ,  A61B18/00 ,  A61B17/00

公开(公告)号：EP3142586A1

公开(公告)日：2017-03-22

申请号：EP15792211.3

申请日：2015-05-13

申请人： President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Children's Medical Center Corporation ,  Massachusetts Institute Of Technology

发明人： WALSH, Conor ,  ROCHE, Ellen ,  POLYGERINOS, Panagiotis ,  SCHUSTER, Lucia ,  KARP, Jeffrey ,  LEE, Yuhan ,  DEL NIDO, Pedro ,  ASSUNTA, Fabozzo ,  FRIEHS, Ingeborg ,  WASSERMAN, Steven

IPC分类号： A61B18/22

摘要： An insertable light-dispensing catheter device, comprising a shaft including a proximal and distal end, a light guide extending through the shaft, and a mirror displaceably extendable from the catheter into a position where the mirror receives and reflects light emitted from the light guide. The mirror can be in the form of a coating on an inflatable balloon; and the balloon, when inflated, can press a patch against a defect (e.g., a ventricular septical defect), while the light cures an adhesive that binds the patch to the structure with the defect, thereby remedying the defect.

摘要翻译： 一种可插入的光分配导管装置，包括一个包括近端和远端的轴，延伸穿过该轴的光导，以及可从该导管可移位地延伸到该镜容纳和反射从该光导发出的光的位置的镜。 镜子可以是充气气球上的涂层的形式; 并且当充气时，气囊可以将贴片压在缺陷（例如，心室脓肿缺损）上，同时光固化粘合剂，使贴片与具有缺陷的结构结合，从而补救缺陷。

公开(公告)号：EP2214590B1

公开(公告)日：2016-08-31

申请号：EP08852120.8

申请日：2008-11-19

申请人： Massachusetts Institute of Technology ,  The Charles Stark Draper Laboratory, Inc.

发明人： KARP, Jeffrey ,  ALBORZ, Mahdavi ,  FERREIRA, Lino ,  CARTER, David ,  ZUMBUEHL, Andreas ,  BORENSTEIN, Jeffrey ,  CHAN, Edwin ,  BETTINGER, Christopher ,  LANGER, Robert

IPC分类号： A61F2/02 ,  A61L31/00 ,  A61L31/14 ,  A61L15/42 ,  A61L15/58 ,  A61L15/64 ,  A61F13/00

CPC分类号： A61F2/0077 ,  A61F2002/30448 ,  A61F2013/00774 ,  A61F2220/0016 ,  A61F2220/005 ,  A61K9/0019 ,  A61L15/42 ,  A61L15/58 ,  A61L15/64 ,  A61L31/005 ,  A61L31/14 ,  A61L31/148 ,  B29C65/18 ,  B29C65/52 ,  B29C66/1122 ,  B31B70/81 ,  B31B2160/10 ,  C04B37/005

公开(公告)号：EP2214590A1

公开(公告)日：2010-08-11

申请号：EP08852120.8

申请日：2008-11-19

申请人： Massachusetts Institute of Technology ,  The Charles Stark Draper Laboratory, Inc.

发明人： KARP, Jeffrey ,  ALBORZ, Mahdavi ,  FERREIRA, Lino ,  CARTER, David ,  ZUMBUEHL, Andreas ,  BORENSTEIN, Jeffrey ,  CHAN, Edwin ,  BETTINGER, Christopher ,  LANGER, Robert

IPC分类号： A61F2/02

CPC分类号： A61F2/0077 ,  A61F2002/30448 ,  A61F2013/00774 ,  A61F2220/0016 ,  A61F2220/005 ,  A61K9/0019 ,  A61L15/42 ,  A61L15/58 ,  A61L15/64 ,  A61L31/005 ,  A61L31/14 ,  A61L31/148 ,  B29C65/18 ,  B29C65/52 ,  B29C66/1122 ,  B31B70/81 ,  B31B2160/10 ,  C04B37/005

摘要： An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.

公开(公告)号：EP1973493A2

公开(公告)日：2008-10-01

申请号：EP07717803.6

申请日：2007-01-12

申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY

发明人： BETTINGER, Christopher, J. ,  KARP, Jeffrey ,  KIM, Sonia, J. ,  LANGER, Robert, S. ,  ZUMBUEHL, Andreas ,  BRUGGEMAN, Joost, P. ,  DA SILVA-FERREIRA, Lino ,  NIJST, Christiaan ,  BURDICK, Jason

IPC分类号： A61F2/00

CPC分类号： A61L31/06 ,  A61K35/12 ,  A61K35/48 ,  A61K45/06 ,  A61L27/18 ,  A61L27/38 ,  A61L27/58 ,  A61L31/148 ,  C08G63/6854 ,  C08J3/24 ,  C08J3/246 ,  C08J2367/00 ,  C08J2367/07 ,  C08K5/0025 ,  C12N11/08 ,  C08L67/00 ,  C08L67/07

摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.