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公开(公告)号：EP1912679A2
公开(公告)日：2008-04-23
申请号：EP06784878.8
申请日：2006-06-14
发明人： ANDERSON, Daniel G. , ZUMBUEHL, Andreas , LESHCHINER, Elizaveta Sergeyevna , LANGER, Robert S. , GOLDBERG, Michael
IPC分类号： A61K48/00
CPC分类号： C07D233/61 , A61K9/1617 , A61K47/18 , A61K47/22 , A61K48/00 , A61K48/0033 , C07C227/10 , C07C229/12 , C07C229/14 , C07C229/16 , C07C229/18 , C07C231/12 , C07C237/06 , C07D211/26 , C07D243/08 , C07D295/12 , C07D307/14 , C07D317/28 , C12N15/88
摘要： Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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公开(公告)号：EP2037851A2
公开(公告)日：2009-03-25
申请号：EP07796554.9
申请日：2007-06-28
发明人： ZUMBUEHL, Andreas , DA SILVA FERREIRA, Lino , KOHANE, Danial, S. , LANGER, Robert, S. , FINK, Gerald, R.
CPC分类号： A61L27/54 , A61L27/34 , A61L2300/404 , A61L2300/602
摘要： This invention is directed to substrates, materials and devices coated with a gel, foam, film, particle or composition comprising a polymei solvent and effector compounds attached thereto, processes of producing the same, and methods of use thereof, of in, inter-alia, biological applications, including preventing infection and the treatment of various diseases.
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3.发明公开
公开(公告)号：EP1991245A2
公开(公告)日：2008-11-19
申请号：EP07751170.7
申请日：2007-02-15
发明人： FERREIRA, Lino , LANGER, Robert, S. , LOOSE, Christopher, R. , O'SHAUGHNESSY, William, Shannan , ZUMBUEHL, Andreas , STEPHANOPOLOUS, Gregory
IPC分类号： A61K38/00
CPC分类号： A61L27/54 , A61K38/10 , A61L2/16 , A61L2/232 , A61L15/46 , A61L27/227 , A61L27/34 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/404
摘要： Antimicrobial peptides enable an alternate approach to developing antimicrobial coatings due to their targeting of the membranes of the bacteria. High specific activity is achieved by orienting the peptides so that the antimicrobial ends of the peptides maximally contact the bacteria. In one embodiment, one end of the peptide is covalently attached directly to the substrate. In another embodiment, the peptides are immobilized on the substrate using a coupling agent or tether. Non-covalent methods include coating the peptide onto the substrate or physiochemically immobilizing the peptides on the substrate using highly specific interactions, such as the biotin/avidin or streptavidin system. The compositions are substantially non-leaching, antifouling, and non-hemolytic. The immobilized peptides retain sufficient flexibility and mobility to interact with and be endocytosed by the bacteria, viruses, and/or fungi upon exposure. Immobilizing the peptides to the substrate reduces concerns regarding toxicity of the peptides and the development of antimicrobial resistance, while presenting substantially all of the peptide at the site of action at the surface of the substrate.
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公开(公告)号：EP2214590B1
公开(公告)日：2016-08-31
申请号：EP08852120.8
申请日：2008-11-19
发明人： KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
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公开(公告)号：EP2214590A1
公开(公告)日：2010-08-11
申请号：EP08852120.8
申请日：2008-11-19
发明人： KARP, Jeffrey , ALBORZ, Mahdavi , FERREIRA, Lino , CARTER, David , ZUMBUEHL, Andreas , BORENSTEIN, Jeffrey , CHAN, Edwin , BETTINGER, Christopher , LANGER, Robert
IPC分类号： A61F2/02
CPC分类号： A61F2/0077 , A61F2002/30448 , A61F2013/00774 , A61F2220/0016 , A61F2220/005 , A61K9/0019 , A61L15/42 , A61L15/58 , A61L15/64 , A61L31/005 , A61L31/14 , A61L31/148 , B29C65/18 , B29C65/52 , B29C66/1122 , B31B70/81 , B31B2160/10 , C04B37/005
摘要： An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
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公开(公告)号：EP1973493A2
公开(公告)日：2008-10-01
申请号：EP07717803.6
申请日：2007-01-12
发明人： BETTINGER, Christopher, J. , KARP, Jeffrey , KIM, Sonia, J. , LANGER, Robert, S. , ZUMBUEHL, Andreas , BRUGGEMAN, Joost, P. , DA SILVA-FERREIRA, Lino , NIJST, Christiaan , BURDICK, Jason
IPC分类号： A61F2/00
CPC分类号： A61L31/06 , A61K35/12 , A61K35/48 , A61K45/06 , A61L27/18 , A61L27/38 , A61L27/58 , A61L31/148 , C08G63/6854 , C08J3/24 , C08J3/246 , C08J2367/00 , C08J2367/07 , C08K5/0025 , C12N11/08 , C08L67/00 , C08L67/07
摘要： The present inventions in various aspects provide elastic biodegradable polymers. In various embodiments, the polymers are formed by the reaction of a multifunctional alcohol or ether and a difunctional or higher order acid to form a pre-polymer, which is cross-linked to form the elastic biodegradable polymer. In preferred embodiments, the cross-linking is performed by functionalization of one or more OR groups on the pre-polymer backbone with vinyl, followed by photopolymerization to form the elastic biodegradable polymer composition or material. Preferably, acrylate is used to add one or more vinyls to the backbone of the pre-polymer to form an acrylated pre-polymer. In various embodiments, acrylated pre-polymers are co-polymerized with one or more acrylated co-polymers.
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