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1.发明公开Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents 失效用于制造放射免疫技术的细胞毒素BISAMIDE BISTHIOL化合物
公开(公告)号：EP0135160A3
公开(公告)日：1985-05-22
申请号：EP84109831
申请日：1984-08-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION
IPC分类号： A61K49/02 , C07F13/00 , C07K05/06 , C07K05/08 , C07C149/247 , C07C149/24 , C07C149/22 , C07D207/46 , C07C149/23 , C07C103/38
CPC分类号： C07K5/0806 , A61K51/0478 , A61K2123/00 , C07C321/00 , C07C323/25 , C07F13/005 , C07K5/0606
摘要： A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide 99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.
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公开(公告)号：EP0200492B1
公开(公告)日：1989-08-02
申请号：EP86303131.6
申请日：1986-04-25
申请人： THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , The Children's Medical Center Corporation
IPC分类号： C07C149/14 , A61K49/02
CPC分类号： C07F13/005 , A61K51/04 , A61K2123/00
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3.发明授权Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents 失效用于制造放射性核素细胞毒物的双嘧啶双酚化合物
公开(公告)号：EP0135160B1
公开(公告)日：1989-04-26
申请号：EP84109831.2
申请日：1984-08-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION
IPC分类号： A61K49/02 , C07F13/00 , C07K5/06 , C07K5/08 , C07C149/247 , C07C149/24
CPC分类号： C07K5/0806 , A61K51/0478 , A61K2123/00 , C07C321/00 , C07C323/25 , C07F13/005 , C07K5/0606
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公开(公告)号：EP0200492A1
公开(公告)日：1986-12-10
申请号：EP86303131.6
申请日：1986-04-25
申请人： THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , The Children's Medical Center Corporation
IPC分类号： C07C149/14 , A61K49/02
摘要： A bisamide-bisthiol ligand containing fatty acid substituted thiol useful for producing Tc-labelled radiodiagnostic imaging agents is described. The ligand forms a complex with the radionuclide 99m Tc suitable for administration as a radiopharmaceutical to obtain images of the heart for diagnosis of myo- ' cardial disfunction. I
摘要翻译： 描述了用于生产Tc标记的放射性诊断显像剂的含有脂肪酸取代的巯基的双酰胺 - 双硫醇配体。 该配体与放射性核素99mTc形成复合物，适合作为放射性药物给药以获得心脏图像以诊断心肌梗塞性功能障碍。 一世
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5.发明公开Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents 失效双酰胺二硫醇化合物在生产用于肾脏含锝放射性诊断剂是有用的。
公开(公告)号：EP0135160A2
公开(公告)日：1985-03-27
申请号：EP84109831.2
申请日：1984-08-17
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , CHILDREN'S MEDICAL CENTER CORPORATION
IPC分类号： A61K49/02 , C07F13/00 , C07K5/06 , C07K5/08 , C07C149/247 , C07C149/24
CPC分类号： C07K5/0806 , A61K51/0478 , A61K2123/00 , C07C321/00 , C07C323/25 , C07F13/005 , C07K5/0606
摘要： A radiodiagnostic bisamido-bisthio ligand useful for producing Tc-labelled radiodiagnostic renal agents is described. The ligand forms a complex with the radionuclide 99m Tc suitable for administration as a radiopharmaceutical to obtain images of the kidney for diagnosis of kidney disfunction.
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6.发明授权Carboxy, carboalkoxy and carbamyl substituted isonitrile radionuclide complexes 失效碳氧化物，碳氧化物和碳水化合物取代的异黄酮放射性核素复合物
公开(公告)号：EP0213945B1
公开(公告)日：1990-09-26
申请号：EP86306694.0
申请日：1986-08-29
IPC分类号： C07C265/04 , C07F13/00 , C07F15/00 , A61K49/02
CPC分类号： C07F13/005 , A61K51/0476 , A61K2123/00 , C07C251/00
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7.发明公开Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents 失效金属异腈加合物在制备用于标记和成像剂的放射性络合物。
公开(公告)号：EP0183555A2
公开(公告)日：1986-06-04
申请号：EP85308681.7
申请日：1985-11-28
IPC分类号： A61K49/02
CPC分类号： C07F13/00 , A61K51/0476 , A61K2123/00 , C07F3/06
摘要： A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, lr, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, TI, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.
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8.发明授权Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents 失效用于制备标记和成像剂的放射性核素复合物的金属 - 异黄酮添加剂
公开(公告)号：EP0183555B1
公开(公告)日：1992-01-22
申请号：EP85308681.7
申请日：1985-11-28
IPC分类号： A61K49/02
CPC分类号： C07F13/00 , A61K51/0476 , A61K2123/00 , C07F3/06
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9.发明公开Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents 失效用于制备标记和成像剂的放射性核素复合物的金属 - 异黄酮添加剂
公开(公告)号：EP0183555A3
公开(公告)日：1988-08-17
申请号：EP85308681
申请日：1985-11-28
IPC分类号： A61K49/02
CPC分类号： C07F13/00 , A61K51/0476 , A61K2123/00 , C07F3/06
摘要： A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, lr, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, TI, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.
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10.发明公开Carboxy, carboalkoxy and carbamyl substituted isonitrile radionuclide complexes 失效羧基，烷氧羰基和氨甲酰取代的异腈的放射性核素配合物。
公开(公告)号：EP0213945A2
公开(公告)日：1987-03-11
申请号：EP86306694.0
申请日：1986-08-29
IPC分类号： C07C265/04 , C07F13/00 , C07F15/00 , A61K49/02
CPC分类号： C07F13/005 , A61K51/0476 , A61K2123/00 , C07C251/00
摘要： A coordination complex is disclosed comprising a radionuclide selected from radioactive isotopes of Tc, Ru, Co. Pt and Re and an isonitrile ligand of the formula:
where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from COOR' and CONR 2 R 3 where R 1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, R 2 , and R 3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R 2 and R 3 can be the same or different. Kits that can be used to form these complexes are also disclosed.
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