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15 条记录 (耗时 0.013 秒)

    Sialic acid-bonded octapeptide and preparation thereof
    1.
    发明公开
    Sialic acid-bonded octapeptide and preparation thereof 失效
    An Sial-Säuregebundenes Oktapeptid und dessen Herstellung。

    公开(公告)号：EP0348892A2

    公开(公告)日：1990-01-03

    申请号：EP89111675.8

    申请日：1989-06-27

    申请人： MECT CORPORATION ,  MITSUI TOATSU CHEMICALS, Inc.

    发明人： Nagai, Yoshitaka ,  Shibayama, Shohei ,  Numata, Masaaki ,  Yoshimura, Shoji ,  Tanaka, Makoto ,  Ito, Masayoshi ,  Awaya, Akira ,  Kobayashi, Hisashi ,  Abe, Hayao ,  Ishizuka, Yusaku ,  Ogawa, Tomoya

    IPC分类号： C07K15/00 ,  C07K9/00 ,  C07K7/06

    CPC分类号： C07K9/005 ,  C07K9/001 ,  Y02P20/55

    摘要： A sialic acid-bonded octapeptide represented by the following general formula (I):
    wherein R represents a hydrogen atom or an acetyl group; and R′ represents a lower alkyl group, an aralkyl group, a hydrogen atom or an alkali metal atom, is herein desclosed. The peptide chain of the sialic acid-bonded octapeptide is constituted by 8 amino acid molecules on the C-terminus side of FTS and the compounds represented by formula (I) can be obtained by bonding sialic acid to the amino terminus of the peptide chain according to condensation. These octapeptides show excellent physiological activity comparable to FTS and a half life in blood longer than that of FTS and it is expected that the affinity of the peptide to lymphocytes is also enhanced. Thus they can effectively be used as medicines for treating the lowering and abnormality of functions of the thymus.

    摘要翻译： 由以下通式（I）表示的唾液酸键合八肽：其中R表示氢原子或乙酰基; R min表示低级烷基，芳烷基，氢原子或碱金属原子。 唾液酸键合的八肽的肽链由FTS的C末端侧的8个氨基酸分子构成，通过将唾液酸键合到肽链的氨基末端，可以得到式（I）所示的化合物， 冷凝。 这些八肽显示与FTS相当的优异的生理活性和血液中的半衰期比FTS更长，并且预期肽对淋巴细胞的亲和力也增强。 因此，它们可以有效地用作治疗胸腺功能降低和异常的药物。

    Glycolipid containing N-glycolylneuraminic acid and method of procuding the same
    10.
    发明公开
    Glycolipid containing N-glycolylneuraminic acid and method of procuding the same 失效
    N-Glykoneuraminsäureenthaltendes Glykolipid und Verfahren zu dessen Herstellung。

    公开(公告)号：EP0264889A2

    公开(公告)日：1988-04-27

    申请号：EP87115283.1

    申请日：1987-10-19

    申请人： MECT CORPORATION

    发明人： Ogawa, Tomoya ,  Numata, Masaaki ,  Sugimoto, Mamoru ,  Shibayama, Shohei ,  Yoshimura, Shoji ,  Ito, Masayoshi ,  Shitori, Yoshiyasu

    IPC分类号： C07H15/10

    CPC分类号： C07H15/10

    摘要： The present invention provides ganglioside-related compounds expressed by the following formula:
    (wherein R 1 denotes a hydrogen atom or SiR 3 R 4 R 5 (wherein R 3 and R 4 each denotes a methyl or phenyl group, and R 5 denotes a tertiary butyl or dimethylphenylmethyl group), and R 2 denotes a hydrogen atom, a trityl group, or
    (wherein M denotes an alkali metal atom)) and methods of producing the same. These ganglioside-related compounds are useful as markers for the early detection of cancer and in the immunotherapy for cancer.

    摘要翻译： 本发明提供由下式表示的神经节苷脂相关化合物：（其中R表示氢原子或SiR 3 R 4 R 5（其中R 3和R 4各自表示甲基或苯基，R 5表示叔丁基或二甲基苯基甲基）， R2表示氢原子，三苯甲基或者CHEM（其中M表示碱金属原子））及其制造方法。 这些神经节苷脂相关化合物可用作早期检测癌症和癌症免疫治疗的标志物。