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公开(公告)号：EP1802635B1
公开(公告)日：2012-06-06
申请号：EP05793907.6
申请日：2005-10-10
IPC分类号： C07D498/18 , C07H19/01
CPC分类号： C07D498/18 , C07H19/01 , Y02P20/55
摘要： A process for the production of 33-Epi-33-chloro-FR 520 in one step from FR520 wherein protecting groups are avoided.
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公开(公告)号：EP1802635B8
公开(公告)日：2013-04-17
申请号：EP05793907.6
申请日：2005-10-10
申请人： MEDA Pharma S.à.r.l.
IPC分类号： C07D498/18 , C07H19/01
CPC分类号： C07D498/18 , C07H19/01 , Y02P20/55
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3.发明公开COMBINATION OF A MACROLIDE AND A LOCAL ANESTHETIC FOR THE TREATMENT OF DERMATOLOGICAL DISEASES 审中-公开组合和局部麻醉剂，用于治疗皮肤疾病的一种大环内酯类
公开(公告)号：EP1613317A1
公开(公告)日：2006-01-11
申请号：EP04725354.7
申请日：2004-04-02
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： A61K31/436 , A61K31/167 , A61K31/08 , A61P17/00
CPC分类号： A61K31/08 , A61K31/167 , A61K31/436 , A61K2300/00
摘要： Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a local anaesthetic such as lidocaine, polidocanol or prilocaine are provided, which are useful in particular in the treatment of dermatological diseases such as atopic, contact or seborrhoeic dermatitis, psoriasis, acne, rosacea, post-peel, pruritus, skin burning, or itching; and associated pain.
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公开(公告)号：EP0994880B1
公开(公告)日：2005-01-19
申请号：EP98936392.4
申请日：1998-06-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： DOSENBACH, Cornelia , GRASSBERGER, Maximilian , HARTMANN, Otto , HORVATH, Amarylla , MUTZ, Jean-Paul , PENN, Gerhard , PFEFFER, Sabine , WIECKHUSEN, Dierk
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C30B7/00
摘要： 33-Epichloro-33-desoxyascomycin of formula (I) and various tautomeric or solvated forms thereof, in crystalline form, such as Form A and Form B. Their preparation involves appropriately converting amorphous compound of formula (I), or compound of formula (I) in other than Form A, or compound of formula (I) in other than Form B, respectively, from a solution thereof under crystallization-inducing conditions or conditions inducing preferential crystallization of Form A or B, respectively. Such crystals are particularly indicated for use in the preparation of topical galenical forms of the compound for pharmaceutical use, e.g. creams, emulsions and ointments.
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公开(公告)号：EP1802635A2
公开(公告)日：2007-07-04
申请号：EP05793907.6
申请日：2005-10-10
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C07H19/01 , Y02P20/55
摘要： A process for the production of 33-Epi-33-chloro-FR 520 in one step from FR520 wherein protecting groups are avoided.
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公开(公告)号：EP1638558A2
公开(公告)日：2006-03-29
申请号：EP04725363.8
申请日：2004-04-02
申请人： Novartis AG , Novartis Pharma GmbH
发明人： GRASSBERGER, Maximilian , HIRSCH, Stefan , MAYER, Friedrich, Karl , SEKKAT, Nabila , STÜTZ, Anton
IPC分类号： A61K31/436 , A61K31/164 , A61P37/00 , A61P17/00
CPC分类号： A61K31/164 , A61K39/39 , A61K2300/00
摘要： Synergistic combination of a macrolide T -cell immunomodulator or immunosuppressant such as 33-epichloro-33desoxyascomycin and a ceramide such as ceramide 3, LPC-9S or linoleic acid are provided, which are useful in particular in the treatment of dermatological or mucosal diseases such as atopic or contact dermatitis or dry skin, asteatotic eczema or xerosis.
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7.发明公开COMBINATION OF A MACROLIDE T-CELL IMMUNOMODULATOR AND A CALCIFEROL FOR THE TREATMENT OF SKIN DISEASES OR OF INFLAMMATORY BOWEL DISEASE 审中-公开大环内酯类T细胞免疫调节剂的WITH A骨化醇FOR皮肤疾病或炎症性肠疾病的治疗组合
公开(公告)号：EP1613330A1
公开(公告)日：2006-01-11
申请号：EP04725344.8
申请日：2004-04-02
申请人： Novartis AG , Novartis Pharma GmbH
发明人： GRASSBERGER, Maximilian , HIRSCH, Stefan , MAYER, Friedrich, Karl , MEINGASSNER, Josef, Gottfried , PAUL, Carle , SEKKAT, Nabila
IPC分类号： A61K31/593 , A61K31/453 , A61P17/00 , A61P1/00
CPC分类号： A61K31/453 , A61K31/593 , A61K2300/00
摘要： Synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and a calciferol such as calcipotriol or tacalcitol are provided, which are useful in particular in the treatment of dermatological diseases such as atopic dermatitis, acne and psoriasis, or of inflammatory bowel disease (IBD).
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