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    APPARATUS TO MINIMIZE THE EFFECTS OF A CARDIAC INSULT
    6.
    发明授权
    APPARATUS TO MINIMIZE THE EFFECTS OF A CARDIAC INSULT 有权
    减少心脏病的影响的设备

    公开(公告)号：EP1339451B1

    公开(公告)日：2009-09-30

    申请号：EP01988608.4

    申请日：2001-10-26

    申请人： MEDTRONIC, INC.

    发明人： HILL, Michael, R., S. ,  KING, Gary, W. ,  MULLEN, Thomas, J. ,  ZHOU, Xiaohong ,  MEHRA, Rahul

    IPC分类号： A61N1/36 ,  A61N1/365

    CPC分类号： A61N1/36114 ,  A61N1/3627

    摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided to peripheral nerves, intrinsic cardiac nerves, sympathetic ganglia, cranial nerves, and may generally be directed to the vertebral column, or within the chest wall of the patient.

    摘要翻译： 提供了用于保护心脏组织免受伤害的方法和设备。 该方法包括识别侮辱（例如心脏病发作）的发生，并且响应于识别侮辱的发生将电刺激传递到患者体内的一个或多个预定神经。 刺激可以被提供给外周神经，内在心脏神经，交感神经节，颅神经，并且可以通常被引导到脊柱或在患者的胸壁内。

    IMPLANTABLE MEDICAL DEVICE FOR TREATING CARDIAC MECHANICAL DYSFUNCTION BY ELECTRICAL STIMULATION
    7.
    发明授权
    IMPLANTABLE MEDICAL DEVICE FOR TREATING CARDIAC MECHANICAL DYSFUNCTION BY ELECTRICAL STIMULATION 有权
    医疗设备，植入机械心功能不全者通过电刺激治疗

    公开(公告)号：EP1347704B1

    公开(公告)日：2007-12-19

    申请号：EP01985621.0

    申请日：2001-12-26

    申请人： MEDTRONIC, INC.

    发明人： DENO, D., Curtis ,  BENNETT, Tom, D. ,  MULLIGAN, Lawrence, J. ,  SHAW, Richard, J. ,  IGEL, David ,  HILL, Michael, R., S.

    IPC分类号： A61B5/00

    CPC分类号： A61N1/3627 ,  A61N1/36564

    摘要： An implantable stimulator and monitor measures a group of heart failure parameters indicative of the state of heart failure employing EGM signals, measures of blood pressure including absolute pressure P, developed pressure (DP = systolic P diastolic P), and/or dP/dt, and measures of heart chamber volume (V) over one or more cardiac cycles. These parameters include: (1) relaxation or contraction time constant tau (t); (2) mechanical restitution (MR), ie., the mechanical response of a heart chamber to premature stimuli applied to the heart chamber; (3) recirculation fraction (RF), i.e., the rate of decay of PESP effects over a series of the heart cycles; and (4) end systolic elastance (EES), i.e., the ratios of end systolic blood pressure P to volume V. These heart failure parameters are determined periodically regardless of patient posture and activity level. The physician can determine whether a particular therapy is appropriate, prescribe the therapy for a period of time while again accumulating the stored patient data for a later review and assessment to determine whether the applied therapy is beneficial or not, thereby enabling periodic changes in therapy, if appropriate. Drug therapies and electrical stimulation therapies, including PESP stimulation, and pacing therapies including single chamber, dual chamber and multi-chamber (bi-atrial and/or bi-ventricular) pacing can be delivered. In patient's prone to malignant tachyarrhythmias, the assessment of heart failure state can be taken into account in setting parameters of detection or classification of tachyarrhythmias and the therapies that are delivered.

    SYSTEM FOR BI-VENTRICULAR FUSION PACING
    8.
    发明授权
    SYSTEM FOR BI-VENTRICULAR FUSION PACING 有权
    双室融合起搏系统

    公开(公告)号：EP1446191B1

    公开(公告)日：2007-11-28

    申请号：EP02763809.7

    申请日：2002-10-01

    申请人： MEDTRONIC, INC.

    发明人： HILL, Michael, R., S.

    IPC分类号： A61N1/368

    CPC分类号： A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    摘要： Bi-ventricular cardiac pacing systems and systems for improving cardiac function for heart failure patients that pace and sense in right and left ventricles of the heart and particularly pace in one of the right and left ventricles after an AV delay timed from a preceding atrial event and after a spontaneous depolarization in the other of the right and left ventricles to achieve fusion pacing. An A-RVp delay and an A-LVp delay are each determined from an intrinsic sensed A-RVs delay and an intrinsic A-LVs delay. If the derived A-LVp delay becomes substantially equal to or shorter than the intrinsic A-RVs delay, then the A-RVp delay is decremented to be shorter than the A-LVp delay. Bi-ventricular pacing of the RV and LV is then established closely timed to the intrinsic RV and LV depolarizations.

    摘要翻译： 用于改善心脏衰竭患者的心脏功能的双心室心脏起搏系统和系统，其在心脏的右心室和左心室中起搏和感觉，并且特别是在从前一个心房事件开始的AV延迟之后的右心室和左心室之一中的起搏，以及 在另一个右心室和左心室自发去极化后实现融合起搏。 A-RVp延迟和A-LVp延迟各自根据内在感测的A-RV延迟和内在A-LV延迟来确定。 如果导出的A-LVp延迟基本上等于或短于固有A-RVs延迟，则A-RVp延迟减少为比A-LVp延迟短。 然后建立RV和LV的双心室起搏，密切定时到固有的RV和LV去极化。

    SENSING CARDIAC ACTIVITY VIA NEUROLOGICAL STIMULATION THERAPY SYSTEM
    9.
    发明公开
    SENSING CARDIAC ACTIVITY VIA NEUROLOGICAL STIMULATION THERAPY SYSTEM 审中-公开
    心脏活动的神经起搏治疗系统测量

    公开(公告)号：EP1827578A1

    公开(公告)日：2007-09-05

    申请号：EP05814824.8

    申请日：2005-10-31

    申请人： Medtronic,Inc.

    发明人： ZHOU, Xiaohong ,  MULLEN, Thomas, J. ,  HILL, Michael, R., S. ,  LAPORTE, Steve, R. ,  KING, Gary, W.

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0551 ,  A61N1/36114 ,  A61N1/36135

    摘要： According to the present invention at least a pair of neurological stimulation electrodes (106) are disposed in, on, about, adjacent and/or within excitable neural tissue (108) of a subject. Cardiac activity of a patient is detected using one or more electrodes (106) adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes (106) deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.