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1.发明授权
公开(公告)号：EP1585573B1
公开(公告)日：2011-08-31
申请号：EP03814252.7
申请日：2003-12-19
申请人： Medtronic, Inc.
IPC分类号： A61N1/00
CPC分类号： A61B5/0452 , A61N1/362 , G06F19/00
摘要： An implantable medical device (IMD) for gauging the severity of ischemia in a patient's heart includes a data collection module configured to receive data about the patient's heart, a data processing module configured to process the data to identify an episode of ischemia in the patient and to determine if the episode is stable or unstable, and a reporting module configured to provide an alarm to the patient if the episode is unstable. A method executable by an implantable medical device to detect ischemia in a human heart suitably includes the steps of receiving data about the heart at the implantable medical device, processing the data within the implantable medical device to determine the severity of ischemia, and providing a response from the implantable medical device to the patient if ischemia is indicated.
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2.发明授权APPARATUS FOR ELECTRICALLY STIMULATING THE NERVOUS SYSTEM TO IMPROVE VENTRICULAR DYSFUNCTION, HEART FAILURE, AND OTHER CARDIAC CONDITIONS 有权DEVICE神经系统电刺激用于治疗心室故障，心力衰竭等心脏条件
公开(公告)号：EP1331965B1
公开(公告)日：2008-07-16
申请号：EP01989165.4
申请日：2001-10-26
申请人： MEDTRONIC, INC.
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are used to provide therapy to a patient experiencing ventricular dysfunction or heart failure. At least one electrode is located in a region associated with nervous tissue, such as nerve bundles T1-T4, in a patient's body. Electrical stimulation is applied to the at least one electrode to improve the cardiac efficiency of the patient's heart. One or more predetermined physiologic parameters of the patient are monitored, and the electrical stimulation is adjusted based on the one or more predetermined physiologic parameters.
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3.发明授权APPARATUS FOR ADJUSTING THE LOCUS OF EXCITATION OF ELECTRICALLY EXCITABLE TISSUE 失效DEVICE FOR SETTING电兴奋性组织的步伐PLACE
公开(公告)号：EP1007148B1
公开(公告)日：2007-04-04
申请号：EP98906426.6
申请日：1998-02-17
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/36017 , A61N1/3615 , A61N1/36167
摘要： The locus of electrically excitable tissue where action potentials are induced, can be controlled. A first pulse (P1) having a first amplitude and a first pulse width is applied to a first electrode (18A) adjacent the tissue to generate a first subthreshold potential area (L10A) within the tissue. A second pulse (P2) having a second amplitude and a second pulse width is applied to a second electrode (16A) adapted to be adjacent the tissue to generate a second subthreshold potential area (L11A) within the tissue. The locus (L12A) within the tissue where action potentials are induced is determined by a superposition of the first and second subthreshold areas according to the physiological principle of electrotonus. The location and size of this locus can be controlled by adjusting at least one of the first and second amplitudes and the first and second pulse widths or the time delay between the first and second pulses.
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公开(公告)号：EP1444003A1
公开(公告)日：2004-08-11
申请号：EP02709759.1
申请日：2002-02-21
申请人： Medtronic, Inc.
发明人： KING, Gary, W.
IPC分类号： A61N1/05
CPC分类号： A61N1/056
摘要： An implantable lead for electrical stimulation of tissue has wire-like extendable members whose tips curl back upon themselves in open tissue spaces to form 2- or 3-dimensional electrodes. The electrodes may be positioned axially or in other directions from the lead body. Traction on the lead body or extendable members allows easy withdrawal as the member tip electrodes uncurl, allowing removal without major surgery. This apparatus and method is useful for minimally invasive insertion of electrodes or electrode arrays, especially through a narrow body lumen or Tuohy needle, providing therapeutic stimulation of nervous tissue, muscle or organs.
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5.发明公开CLOSED-LOOP NEUROMODULATION FOR PREVENTION AND TREATMENT OF CARDIAC CONDITIONS 审中-公开神经调节的闭环为防止及治疗心脏疾病的
公开(公告)号：EP1395335A1
公开(公告)日：2004-03-10
申请号：EP01995332.2
申请日：2001-10-26
申请人： Medtronic, Inc.
CPC分类号： A61N1/36114 , A61N1/3627
摘要： a method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering electrical stimulation to one or more predetermined portions of the nervous system in a patient's body; and monitoring one or more physiologic indices of the body to determine whether the delivered therapy is effective. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the patient's body, and then the physiologic response of the patient is monitored to determine the efficacy of the stimulation.
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公开(公告)号：EP1904173B8
公开(公告)日：2016-06-08
申请号：EP06772860.0
申请日：2006-06-09
申请人： Medtronic, Inc.
发明人： ROONEY, Ethan, A. , WAHLSTRAND, Carl, D. , KING, Gary, W. , CROSS, Thomas, E. , STONE, Richard, T.
CPC分类号： A61N1/375 , A61N1/0504 , A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36071 , A61N1/3756
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公开(公告)号：EP2318091A1
公开(公告)日：2011-05-11
申请号：EP09743106.8
申请日：2009-01-23
申请人： MEDTRONIC, INC.
发明人： KING, Gary, W. , GOETZ, Steven, M. , HOUCHINS, Andrew, H. , KEACHER, Jeffrey, T. , GREENBERG, Jordan, J. , HERUTH, Kenneth, T. , LENT, Mark, S. , WACNIK, Paul, W.
IPC分类号： A61N1/34
CPC分类号： A61N1/36139 , A61N1/36057 , A61N1/36071
摘要： Peripheral nerve field stimulation (PNFS) may be controlled based on detected physiological effects of the PNFS, which may be an efferent response to the PNFS. In some examples, a closed-loop therapy system may include a sensing module that senses a physiological parameter of the patient, which may be indicative of the patient's response to the PNFS. Based on a signal generated by the sensing module, the PNFS may be activated, deactivated or modified. Example physiological parameters of the patient include heart rate, respiratory rate, electrodermal activity, muscle activity, blood flow rate, sweat gland activity, pilomotor reflex, or thermal activity of the patient's body. In some examples, a patient pain state may be detected based on a signal generated by the sensing module, and therapy may be controlled based on the detection of the pain state.
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公开(公告)号：EP1904154B1
公开(公告)日：2011-01-26
申请号：EP06760740.8
申请日：2006-06-09
申请人： Medtronic, Inc.
发明人： ROONEY, Ethan, A. , WAHLSTRAND, Carl, D. , KING, Gary, W. , CROSS, Thomas, E. , STONE, Richard, T.
IPC分类号： A61N1/05
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0553 , A61N1/36071 , A61N1/37211
摘要： The disclosure describes an implantable medical lead for delivering stimulation to a patient. Electrodes may be located on two or more surfaces of the lead to, for example, selectively deliver stimulation to one or more tissue layers within the patient. The lead may be implanted within or between intra-dermal, deep dermal, or subcutaneous tissue layers, and may be used to, for example, deliver peripheral nerve field stimulation to treat pain experienced by the patient at the site at which the lead is implanted. The lead may comprise a paddle lead or a multiple level lead, e.g., a lead having a plurality of flat or paddle shaped lead bodies arranged in substantially parallel planes. Further, the lead may include fixation structures on the distal end, proximal end, or both ends to prevent migration.
摘要翻译： 本公开描述了用于向患者传递刺激的可植入医疗导线。 电极可以位于引线的两个或更多个表面上，以例如选择性地向患者体内的一个或多个组织层递送刺激。 引线可以被植入到真皮内，深层真皮或皮下组织层内或真皮层，深层真皮层或皮下组织层内，并且可以用于例如递送周围神经区刺激以治疗患者在植入引线的部位所经历的疼痛 。 引线可以包括桨形引线或多级引线，例如具有布置在基本上平行的平面中的多个扁平或桨形引线体的引线。 此外，引线可以在远端，近端或两端包括固定结构以防止迁移。
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公开(公告)号：EP1330287B1
公开(公告)日：2009-07-29
申请号：EP01988607.6
申请日：2001-10-26
申请人： MEDTRONIC, INC.
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in patient's body in response to identifying the occurrence of the insult. The stimulation may be provided at the spinal canal or on the chest wall of the patient through cutaneous electrodes.
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公开(公告)号：EP1075307B1
公开(公告)日：2008-07-09
申请号：EP99918478.1
申请日：1999-04-09
申请人： MEDTRONIC, INC.
发明人： KING, Gary, W.
IPC分类号： A61N1/36
CPC分类号： A61N1/3605 , A61N1/36071 , A61N1/36117
摘要： The present invention discloses techniques for therapeutically treating peripheral vascular disease. A sensor is implemented for sensing the extent of blood flow in a patient's limb or ischemic pain and generating a corresponding sensor signal. The signal is processed to determine the level of spinal cord stimulation or perihperal nerve stimulation to be applied. This information is provided to a signal generator which thereby provides electrical stimulation energy to one or more stimulation leads. Stimulation of the spinal cord, peripheral nerve or neural tissue ganglia thereby improves blood flow, helps restore tissue health and reduces the extent of ischemic pain in the limbs of a PVD patient or organs of other patients. The present invention thereby allows the stimulation to be adjusted automatically to account for changing conditions of the patient throughout the day.
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