公开(公告)号：EP0525199A4

公开(公告)日：1994-08-17

申请号：EP92903328

申请日：1992-01-17

申请人： MEITO SANGYO KK

发明人： KITO KYOJI BENTENGAOKA ,  NAGAE HIDEO - HIGASHINO-CHO -C ,  HASEGAWA MASAKATSU DOUTOKUSHIN ,  ITO YOSHIO - YAMAHANA-CHO SHOW ,  MIZUTANI AKIHIRO TOGAN-CHO -CH ,  HIROSE KIMIO AWANONISHI -CHOME ,  OHGAI MASAHIRO SHIGA-CHO -CHOM ,  YAMASHITA YASUJI SASAZUKA-CHO ,  TOZAWA NAHOKO - HIGASHIYAMA-CH ,  YAMADA KEIKO - MAKISHINDEN-CHO ,  HOKUKOKU SHUSABURO WAKABADAI -

IPC分类号： A61K9/50 ,  A61K47/48 ,  A61K49/18 ,  A61K49/00

CPC分类号： A61K49/1863 ,  A61K9/5094 ,  G01N2400/22 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/80 ,  Y10S436/806 ,  Y10T436/24

摘要： A composition containing ultrafine particles of a magnetic metal oxide, characterized by comprising an aqueous sol of a composite consisting of the ultrafine particles and a polysaccharide, its derivative and/or a protein, and an organic monocarboxylic acid. This composition is useful in the fields of medicines, diagnostic chemicals and so forth, because it is free from side effects such as platelet agglutination, is excellent in the safety for living organism, and does not adversely affect the living organisms even when administered in the blood vessel.

公开(公告)号：EP0543020B1

公开(公告)日：1997-12-29

申请号：EP92911159

申请日：1992-06-08

申请人： MEITO SANGYO KK

发明人： HASEGAWA MASAKATSU ,  NAGAE HIDEO ,  ITO YOSHIO ,  MIZUTANI AKIHIRO ,  HIROSE KIMIO ,  OHGAI MASAHIRO ,  YAMASHITA YASUJI ,  TOZAWA NAHOKO ,  YAMADA KEITO ,  KITO KYOJI BENTENGAOKA MORIYAM ,  HOKUKOKU SHUSABURO WAKABADAI -

IPC分类号： C07D239/34 ,  A01N43/54 ,  A01N43/66 ,  A61K33/26 ,  A61K41/00 ,  A61K49/18 ,  C07D239/38 ,  C07D239/47 ,  C07D239/56 ,  C07D239/60 ,  C07D251/30 ,  C07F9/6512 ,  C07F9/6521 ,  C08B31/18 ,  C08B37/02 ,  C08K3/22 ,  C08L3/10 ,  C08L5/00 ,  A61K49/00 ,  C08B37/00 ,  C08B37/12 ,  C08B37/18

CPC分类号： A61K49/1863 ,  A01N43/54 ,  A01N43/66 ,  A61K33/26 ,  A61K41/0052 ,  C07D239/60 ,  C07D251/30 ,  C07F9/65122 ,  C08B37/0021 ,  C08K3/22 ,  C08L3/10 ,  C08L5/00 ,  G01N2400/16 ,  G01N2400/22 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/86 ,  Y10T436/24 ,  A61K31/715 ,  A61K2300/00

摘要： An oxidized composite comprising a water-soluble carboxypolysaccharide and ultrafine magnetic iron oxide particles. It has an extremely reduces toxicity and an excellent stability, exhibits scarcely any or no hypotensive activity even if directly administered into the blood vessel of an animal, is reduced in the activity of platelet agglutination, and is useful in the medical field as, for example, a contrast medium for MRI and a pyrogenic agent for thermotherapy.