公开(公告)号：EP1896857A4

公开(公告)日：2008-12-31

申请号：EP06780818

申请日：2006-06-29

申请人： FUJIFILM CORP

发明人： ABE YOSHIHIKO ,  KAGEYAMA SHIGEKI ,  HIRAI HIROYUKI ,  KOJIMA MASAYOSHI

IPC分类号： G01N33/92 ,  G01N33/48

CPC分类号： G01N33/5434 ,  G01N33/92 ,  G01N2446/80

摘要： An object to be achieved by the present invention is to provide a method for determining the amount of a component contained in a specific lipoprotein fraction in a biological sample using an automatic analyzer, without the requirement of a step of fractionating a sample by centrifugation. The present invention provides a method for separating a target component in a biological sample, which comprises the steps of: (1) causing a biological sample to come into contact with independently dispersed magnetic nanoparticles having a particle size of 50 nm or less, which have anionic functional groups on their surfaces, so as to form an agglutinate of the magnetic nanoparticles and biomolecules capable of interacting with the magnetic nanoparticles; and (2) collecting the agglutinate by an external magnetic field.

公开(公告)号：EP1407268A2

公开(公告)日：2004-04-14

申请号：EP02758194.1

申请日：2002-05-14

申请人： Nimbus Biotechnologie Gmbh

发明人： SCHMITT, Johannes ,  NÖLLER, Joachim

IPC分类号： G01N33/543

CPC分类号： G01N33/553 ,  G01N33/54326 ,  G01N33/54386 ,  G01N33/552 ,  G01N2446/80

摘要： The invention relates to a method suitable for the production of immobilized double lipid layers, comprising an inner and an outer lipid layer. The inner and outer lipid layer of said double lipid layers have a defined orientation on the surface of a solid body and are immobilized on the surface of said solid body in a substantially stable and dynamic manner. In order to carry out the inventive method, the surface of a solid body is initially modified in such a way that a surface is formed which preferably interacts with only one of the two lipid layers. In a second step, a double lipid layer is deposited on said modified surface. Preferably, other components, especially protein, are inserted into the double lipid layer.

公开(公告)号：EP0525199B2

公开(公告)日：2004-04-14

申请号：EP92903328.0

申请日：1992-01-17

申请人： MEITO SANGYO KABUSHIKI KAISHA

发明人： KITO, Kyoji 701, Bentengaoka ,  NAGAE, Hideo 8-7, Higashino-cho 2-chome ,  HASEGAWA, Masakatsu 29, Doutokushin-machi 5-chome ,  ITO, Yoshio 203-3, Yamahana-cho Showa-ku ,  MIZUTANI, Akihiro 48, Togan-cho 2-chome Nishi-ku ,  HIROSE, Kimio 433, Awanonishi 1-chome ,  OHGAI, Masahiro 68, Shiga-cho 2-chome Kita-ku ,  YAMASHITA, Yasuji 7, Sasazuka-cho 1-chome ,  TOZAWA, Nahoko 170-4, Higashiyama-cho 1-chome ,  YAMADA, Keiko 10-2, Makishinden-cho ,  HOKUKOKU, Shusaburo 55, Wakabadai 8-chome

IPC分类号： A61K49/00

CPC分类号： A61K49/1863 ,  A61K9/5094 ,  G01N2400/22 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/80 ,  Y10S436/806 ,  Y10T436/24

摘要： A composition containing ultrafine particles of a magnetic metal oxide, characterized by comprising an aqueous sol of a composite consisting of the ultrafine particles and a polysaccharide, its derivative and/or a protein, and an organic monocarboxylic acid. This composition is useful in the fields of medicines, diagnostic chemicals and so forth, because it is free from side effects such as platelet agglutination, is excellent in the safety for living organism, and does not adversely affect the living organisms even when administered in the blood vessel.

公开(公告)号：EP0489119B1

公开(公告)日：1996-05-08

申请号：EP90914444.6

申请日：1990-08-14

申请人： IMMUNICON CORPORATION

发明人： LIBERTI, Paul, A. ,  PINO, Maria, A.

IPC分类号： C12Q1/10 ,  G01N33/53 ,  C12N11/06 ,  G01N33/553 ,  B32B5/16 ,  A01N1/02 ,  C01G49/08 ,  B01D35/06

CPC分类号： H01F1/445 ,  A61K9/5094 ,  A61K49/1833 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1869 ,  A61K49/1875 ,  B03C1/01 ,  C12N11/14 ,  G01N33/54333 ,  G01N33/5434 ,  G01N33/54393 ,  G01N2333/765 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/80 ,  Y10T428/2982 ,  Y10T428/2991

摘要： Stable suspensions of coated magnetic particles, preferably resuspendable bioactive particles particularly useful in Magnetic Resonance Imaging, are produced by disrupting, what are presumed to be, crystalline agglomerates of a parent particulate magnetic starting material in the presence of a coating material, such that coating can take place during the disruption. The particles are generally coated in suspension yielding a stable suspension of subdivided particles. With the proper selection of a coating material, preferably a protein or other biochemically or biologically active polymer such as an antibody, a resuspendable (colloidal) bioactive product is obtained.

公开(公告)号：EP0343934A3

公开(公告)日：1990-11-22

申请号：EP89305215.9

申请日：1989-05-23

申请人： ANAGEN (U.K.) LIMITED

发明人： Sang, Jean Victor ,  Groves, Paul ,  Burrell, Robert Edward ,  Flynn, Gerard

IPC分类号： H01F1/36 ,  H01F1/37

CPC分类号： G01N33/5434 ,  B03C1/01 ,  G01N2446/20 ,  G01N2446/80 ,  H01F1/36 ,  H01F1/445 ,  Y10T428/2989

摘要： Magnetically attractable particles comprise a core of magnetic material encapsulated in a metal oxide coating. They may be made by emulsifying an aqueous solution or dispersion of the magnetic material or precursor, and an aqueous solution or sol of a coating inorganic oxide or precursor, in an inert water-­immiscible liquid. The aqueous droplets are gelled, e.g. by ammonia or an amine, recovered, and heated at 250 - 2000 o C. The resulting particles are generally smooth spheres below 100 microns in diameter and often of sub-micron size.

公开(公告)号：EP1988928A1

公开(公告)日：2008-11-12

申请号：EP07709086.8

申请日：2007-02-23

申请人： Atgen Co.Ltd.

发明人： HAM, Seung-Joo ,  SUH, Jin-Suck ,  HUH, Yong-Min ,  YOON, Ho-Geun ,  YANG, Jae-Moon

IPC分类号： A61K49/06

CPC分类号： G01N33/574 ,  A61K41/0052 ,  A61K47/593 ,  A61K47/60 ,  A61K47/6923 ,  A61K49/1806 ,  A61K49/1833 ,  A61K49/1836 ,  A61K49/1839 ,  A61K49/1851 ,  A61K49/1857 ,  A61K49/186 ,  A61K49/1875 ,  A61K49/1887 ,  B82Y5/00 ,  G01N33/5434 ,  G01N2446/80

摘要： The present invention relates to water soluble magnetic nanocomposite using an amphiphilic compound. Specifically, the present invention relates to water soluble magnetic nanocomposite which may be not only used as a contrast agent for magnetic resonance imaging (MRI), an intelligent contrast agent for diagnosing cancer characterized by binding a tissue-specific binder ingredient, a drug delivery system for simultaneous diagnosis and treatment by polymerizing or enveloping drugs and binding a tissue-specific binder ingredient, but also used for separating a target substance using magnetism, and a process for preparing the same.

公开(公告)号：EP1896857A1

公开(公告)日：2008-03-12

申请号：EP06780818.8

申请日：2006-06-29

申请人： FUJIFILM Corporation

发明人： ABE, Yoshihiko, c/o Fuji Film Corporation ,  KAGEYAMA, Shigeki, c/o Fuji Film Corporation ,  HIRAI, Hiroyuki, c/o Fuji Film Corporation ,  KOJIMA, Masayoshi, c/o Fuji Film Corporation

IPC分类号： G01N33/92 ,  G01N33/48

CPC分类号： G01N33/5434 ,  G01N33/92 ,  G01N2446/80

摘要： An object to be achieved by the present invention is to provide a method for determining the amount of a component contained in a specific lipoprotein fraction in a biological sample using an automatic analyzer, without the requirement of a step of fractionating a sample by centrifugation. The present invention provides a method for separating a target component in a biological sample, which comprises the steps of: (1) causing a biological sample to come into contact with independently dispersed magnetic nanoparticles having a particle size of 50 nm or less, which have anionic functional groups on their surfaces, so as to form an agglutinate of the magnetic nanoparticles and biomolecules capable of interacting with the magnetic nanoparticles; and (2) collecting the agglutinate by an external magnetic field.

摘要翻译： 本发明要实现的目的是提供一种使用自动分析仪测定生物样品中特定脂蛋白级分中所含成分的量的方法，而不需要通过离心分离样品的步骤。 本发明提供了一种用于分离生物样品中的目标组分的方法，其包括以下步骤：（1）使生物样品与独立分散的具有50nm或更小粒径的磁性纳米粒子接触，所述磁性纳米粒子具有50nm或更小的粒径 阴离子官能团，从而形成磁性纳米颗粒和能够与磁性纳米颗粒相互作用的生物分子的凝集物; 和（2）通过外部磁场收集凝集物。

公开(公告)号：EP0811652A3

公开(公告)日：1998-01-14

申请号：EP97109178.0

申请日：1997-06-06

申请人： BOEHRINGER MANNHEIM GMBH

发明人： Harttig, Herbert, Dr.

IPC分类号： C08J3/12 ,  B03C1/01

CPC分类号： B03C1/01 ,  C08J3/124 ,  G01N33/5434 ,  G01N2446/80

摘要： Die Erfindung betrifft ein Verfahren zur Herstellung einer trockenen Polymerbeadzubereitung. Hierzu werden die Polymerbeads mit einer Schicht eines leichtlöslichen Stoffes überzogen, welcher sich bei Resuspension der Polymerbeads in einer Flüssigkeit wieder auflöst. Die Resuspension ist dadurch weitgehend agglomeratfrei möglich.

摘要翻译： 本发明涉及制备干聚合物珠粒制备物的方法。 为此目的，聚合物珠涂覆有易溶物质层，在将聚合物珠再悬浮于液体中的情况下再次溶解。 重新悬浮在很大程度上可能是免费的团聚。

公开(公告)号：EP0489119A4

公开(公告)日：1992-07-01

申请号：EP90914444

申请日：1990-08-14

申请人： IMMUNICON CORPORATION

发明人： LIBERTI, PAUL, A. ,  PINO, MARIA, A.

IPC分类号： A61K49/00 ,  A61K9/50 ,  A61K49/18 ,  B01D35/06 ,  B03C1/01 ,  C12N1/02 ,  C12N11/14 ,  G01N33/543 ,  G01R33/28 ,  H01F1/34 ,  H01F1/44 ,  C12Q1/10 ,  A01N1/02 ,  B32B5/16 ,  C01G49/08 ,  C12N11/06 ,  G01N33/53 ,  G01N33/553

CPC分类号： H01F1/445 ,  A61K9/5094 ,  A61K49/1833 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1869 ,  A61K49/1875 ,  B03C1/01 ,  C12N11/14 ,  G01N33/54333 ,  G01N33/5434 ,  G01N33/54393 ,  G01N2333/765 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/80 ,  Y10T428/2982 ,  Y10T428/2991

摘要： Stable suspensions of coated magnetic particles, preferably resuspendable bioactive particles particularly useful in Magnetic Resonance Imaging, are produced by disrupting, what are presumed to be, crystalline agglomerates of a parent particulate magnetic starting material in the presence of a coating material, such that coating can take place during the disruption. The particles are generally coated in suspension yielding a stable suspension of subdivided particles. With the proper selection of a coating material, preferably a protein or other biochemically or biologically active polymer such as an antibody, a resuspendable (colloidal) bioactive product is obtained.

公开(公告)号：EP0284549A3

公开(公告)日：1989-09-13

申请号：EP88730073.9

申请日：1988-03-23

申请人： SILICA GEL GESELLSCHAFT MBH ADSORPTIONS-TECHNIK, APPARATEBAU ,  Pilgrimm, Herbert Dr.

发明人： Pilgrimm, Herbert, Dr.

IPC分类号： A61K49/00 ,  A61K49/02 ,  A61K49/04 ,  A61K47/00

CPC分类号： A61K33/26 ,  A61K9/5094 ,  A61K49/1806 ,  G01N2446/20 ,  G01N2446/80 ,  G01N2446/90 ,  Y10T436/24

摘要： Die magnetischen Flüssigkeitzusammensetzungen bestehen aus physiologisch verträglichen, magnetfeldstabilen Dis­persionen von superparamagnetischen Teilchen in Wasser. Die Herstellung der magnetischen Flüssigkeitszusammenset­zungen erfolgt durch eine chemische Bindung von Stabili­satorsubstanzen, diagnostisch und pharmakologisch wirk­samen Substanzen auf der Oberfläche von superparamagneti­schen Teilchen. Die magnetischen Flüssigkeitszusammenset­zungen sind in der Medizin und Veterinärmedizin für die in vitro und in vivo Diagnostik und Therapie sowie in vielen Bereichen der Wissenschaft und Technik anwendbar.