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1.发明公开OXIDIZED COMPOSITE COMPRISING WATER-SOLUBLE CARBOXYPOLYSACCHARIDE AND MAGNETIC IRON OXIDE 失效氧化成分含有水溶性羧基的多糖和磁性氧化铁。
公开(公告)号：EP0543020A1
公开(公告)日：1993-05-26
申请号：EP92911159.9
申请日：1992-06-08
发明人： HASEGAWA, Masakatsu, 29, Doutokushin-machi 5-chome , NAGAE, Hideo, 8-7, Higashino-cho 2-chome , ITO, Yoshio, 203-3, Yamahana-cho Showa-ku , MIZUTANI, Akihiro, 48, Togan-cho 2-chome Nishi-ku , HIROSE, Kimio, 433, Awanonishi 1-chome , OHGAI, Masahiro, 68, Shiga-cho 2-chome Kita-ku , YAMASHITA, Yasuji, 7, Sasazuka-cho 1-chome , TOZAWA, Nahoko, 170-4, Higashiyama-cho 1-chome , YAMADA, Keito, 10-2, Makishinden-cho , KITO, Kyoji, 701, Bentengaoka Moriyama-ku , HOKUKOKU, Shusaburo, 55, Wakabadai 8-chome
CPC分类号： A61K49/1863 , A01N43/54 , A01N43/66 , A61K33/26 , A61K41/0052 , C07D239/60 , C07D251/30 , C07F9/65122 , C08B37/0021 , C08K3/22 , C08L3/10 , C08L5/00 , G01N2400/16 , G01N2400/22 , G01N2446/20 , G01N2446/30 , G01N2446/86 , Y10T436/24 , A61K31/715 , A61K2300/00
摘要： An oxidized composite comprising a water-soluble carboxypolysaccharide and ultrafine magnetic iron oxide particles. It has an extremely reduces toxicity and an excellent stability, exhibits scarcely any or no hypotensive activity even if directly administered into the blood vessel of an animal, is reduced in the activity of platelet agglutination, and is useful in the medical field as, for example, a contrast medium for MRI and a pyrogenic agent for thermotherapy.
摘要翻译： 氧化复合物，包括水溶性羧基多糖和超细的磁性氧化铁颗粒。 它具有非常降低的毒性和优良的稳定性，展品几乎没有任何或即使直接施用到动物中的血管没有降血压活性，血小板凝集的活性降低，是在医学领域是有用的，对于实施例 用于MRI的造影剂和用于热疗有发热剂。
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2.发明公开OXIDIZED COMPOSITE COMPRISING WATER-SOLUBLE CARBOXYPOLYSACCHARIDE AND MAGNETIC IRON OXIDE 失效包含水溶性碳氧化物和氧化铁的氧化复合材料
公开(公告)号：EP0543020A4
公开(公告)日：1993-12-01
申请号：EP92911159
申请日：1992-06-08
发明人： HASEGAWA, MASAKATSU, 29, DOUTOKUSHIN-MACHI 5-CHOME , NAGAE, HIDEO, 8-7, HIGASHINO-CHO 2-CHOME , ITO, YOSHIO, 203-3, YAMAHANA-CHO SHOWA-KU , MIZUTANI, AKIHIRO, 48, TOGAN-CHO 2-CHOME NISHI-KU , HIROSE, KIMIO, 433, AWANONISHI 1-CHOME , OHGAI, MASAHIRO, 68, SHIGA-CHO 2-CHOME KITA-KU , YAMASHITA, YASUJI, 7, SASAZUKA-CHO 1-CHOME , TOZAWA, NAHOKO, 170-4, HIGASHIYAMA-CHO 1-CHOME , YAMADA, KEITO, 10-2, MAKISHINDEN-CHO , KITO, KYOJI, 701, BENTENGAOKA MORIYAMA-KU , HOKUKOKU, SHUSABURO, 55, WAKABADAI 8-CHOME
IPC分类号： C07D239/34 , A01N43/54 , A01N43/66 , A61K33/26 , A61K41/00 , A61K49/18 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60 , C07D251/30 , C07F9/6512 , C07F9/6521 , C08B31/18 , C08B37/02 , C08K3/22 , C08L3/10 , C08L5/00
CPC分类号： A61K49/1863 , A01N43/54 , A01N43/66 , A61K33/26 , A61K41/0052 , C07D239/60 , C07D251/30 , C07F9/65122 , C08B37/0021 , C08K3/22 , C08L3/10 , C08L5/00 , G01N2400/16 , G01N2400/22 , G01N2446/20 , G01N2446/30 , G01N2446/86 , Y10T436/24 , A61K31/715 , A61K2300/00
摘要： An oxidized composite comprising a water-soluble carboxypolysaccharide and ultrafine magnetic iron oxide particles. It has an extremely reduces toxicity and an excellent stability, exhibits scarcely any or no hypotensive activity even if directly administered into the blood vessel of an animal, is reduced in the activity of platelet agglutination, and is useful in the medical field as, for example, a contrast medium for MRI and a pyrogenic agent for thermotherapy.
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公开(公告)号：EP1048739B1
公开(公告)日：2005-09-07
申请号：EP98956015.6
申请日：1998-12-01
申请人： KIKKOMAN CORPORATION
发明人： HATTORI, Noriaki, Kikkoman Corporation , YAJITATE, Keiko, Kikkoman Corporation , NAKAJIMA, Motoo, Kikkoman Corporation , MURAKAMI, Seiji, Kikkoman Corporation
IPC分类号： C12Q1/66
CPC分类号： G01N33/66 , C12Q1/66 , C12Q2304/60 , G01N2400/16 , G01N2400/18
摘要： A method for analyzing intracellular components characterized by involving the following steps; and kits containing (a) an extractant, (b) a branched dextrin or its derivative, and (c) a reagent for analyzing intracellular components: (1) the step of adding the extractant to a sample containing cells to thereby extract intracellular components; (2) the step of adding the branched dextrin or its derivative to the sample containing the extractant; and (3) the step of analyzing the thus extracted intracellular components. The use of the branched dextrin or its derivative makes it possible to prevent the extractant from inhibiting the analysis steps.
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4.发明公开
公开(公告)号：EP1048739A4
公开(公告)日：2004-06-30
申请号：EP98956015
申请日：1998-12-01
申请人： KIKKOMAN CORP
CPC分类号： G01N33/66 , C12Q1/66 , C12Q2304/60 , G01N2400/16 , G01N2400/18
摘要： A method for analyzing intracellular components characterized by involving the following steps; and kits containing (a) an extractant, (b) a branched dextrin or its derivative, and (c) a reagent for analyzing intracellular components: (1) the step of adding the extractant to a sample containing cells to thereby extract intracellular components; (2) the step of adding the branched dextrin or its derivative to the sample containing the extractant; and (3) the step of analyzing the thus extracted intracellular components. The use of the branched dextrin or its derivative makes it possible to prevent the extractant from inhibiting the analysis steps.
摘要翻译： 一种分析细胞内成分的方法，其特征在于包括以下步骤： 和（a）提取剂，（b）支链糊精或其衍生物的试剂盒和（c）用于分析细胞内成分的试剂：（1）将提取剂加入到含有细胞的样品中从而提取细胞内成分的步骤; （2）将分支糊精或其衍生物加入含有萃取剂的样品的步骤; 和（3）分析由此提取的细胞内组分的步骤。 使用分支糊精或其衍生物可以防止萃取剂抑制分析步骤。
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公开(公告)号：EP1048739A1
公开(公告)日：2000-11-02
申请号：EP98956015
申请日：1998-12-01
申请人： KIKKOMAN CORP
CPC分类号： G01N33/66 , C12Q1/66 , C12Q2304/60 , G01N2400/16 , G01N2400/18
摘要： A method for analyzing intracellular components characterized by involving the following steps; and kits containing (a) an extractant, (b) a branched dextrin or its derivative, and (c) a reagent for analyzing intracellular components: (1) the step of adding the extractant to a sample containing cells to thereby extract intracellular components; (2) the step of adding the branched dextrin or its derivative to the sample containing the extractant; and (3) the step of analyzing the thus extracted intracellular components. The use of the branched dextrin or its derivative makes it possible to prevent the extractant from inhibiting the analysis steps.
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6.发明授权OXIDIZED COMPOSITE COMPRISING WATER-SOLUBLE CARBOXYPOLYSACCHARIDE AND MAGNETIC IRON OXIDE 失效氧化成分含有水溶性carboxypolysaccharide和磁性氧化铁
公开(公告)号：EP0543020B1
公开(公告)日：1997-12-29
申请号：EP92911159
申请日：1992-06-08
申请人： MEITO SANGYO KK
发明人： HASEGAWA MASAKATSU , NAGAE HIDEO , ITO YOSHIO , MIZUTANI AKIHIRO , HIROSE KIMIO , OHGAI MASAHIRO , YAMASHITA YASUJI , TOZAWA NAHOKO , YAMADA KEITO , KITO KYOJI BENTENGAOKA MORIYAM , HOKUKOKU SHUSABURO WAKABADAI -
IPC分类号： C07D239/34 , A01N43/54 , A01N43/66 , A61K33/26 , A61K41/00 , A61K49/18 , C07D239/38 , C07D239/47 , C07D239/56 , C07D239/60 , C07D251/30 , C07F9/6512 , C07F9/6521 , C08B31/18 , C08B37/02 , C08K3/22 , C08L3/10 , C08L5/00 , A61K49/00 , C08B37/00 , C08B37/12 , C08B37/18
CPC分类号： A61K49/1863 , A01N43/54 , A01N43/66 , A61K33/26 , A61K41/0052 , C07D239/60 , C07D251/30 , C07F9/65122 , C08B37/0021 , C08K3/22 , C08L3/10 , C08L5/00 , G01N2400/16 , G01N2400/22 , G01N2446/20 , G01N2446/30 , G01N2446/86 , Y10T436/24 , A61K31/715 , A61K2300/00
摘要： An oxidized composite comprising a water-soluble carboxypolysaccharide and ultrafine magnetic iron oxide particles. It has an extremely reduces toxicity and an excellent stability, exhibits scarcely any or no hypotensive activity even if directly administered into the blood vessel of an animal, is reduced in the activity of platelet agglutination, and is useful in the medical field as, for example, a contrast medium for MRI and a pyrogenic agent for thermotherapy.
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