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    ANTIVIRAL RESISTANCE MUTANTS AND APPLICATIONS THEREOF
    2.
    发明公开
    ANTIVIRAL RESISTANCE MUTANTS AND APPLICATIONS THEREOF 有权
    抗病毒耐药性突变体及其应用

    公开(公告)号：EP1948800A4

    公开(公告)日：2010-07-21

    申请号：EP06790408

    申请日：2006-10-20

    申请人： MELBOURNE HEALTH ,  AUSTIN HEALTH

    发明人： BARTHOLOMEUSZ ANGELINE INGRID ,  LOCARNINI STEPHEN ,  AYRES ANNA ,  LITTLEJOHN MARGARET ,  ANGUS PETER WILLIAM

    IPC分类号： C12N15/51 ,  A61K35/76 ,  C12N7/06

    CPC分类号： A61K35/76 ,  C12N7/00 ,  C12N2730/10132 ,  C12Q1/18

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to agents such as nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs or other DNA polymerase antagonists and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

    VARIANTS OF HEPATITIS B VIRUS WITH RESISTANCE TO ANTI-VIRAL NUCLEOSIDE AGENTS AND APPLICATIONS THEREOF
    4.
    发明公开
    VARIANTS OF HEPATITIS B VIRUS WITH RESISTANCE TO ANTI-VIRAL NUCLEOSIDE AGENTS AND APPLICATIONS THEREOF 审中-公开
    乙型肝炎病毒与抗抗病毒NUKLEOSIDAGENTIEN和变化及其用途

    公开(公告)号：EP1874923A4

    公开(公告)日：2010-08-04

    申请号：EP06721332

    申请日：2006-04-04

    申请人： MELBOURNE HEALTH ,  ST VINCENTS HOSP MELBOURNE LTD ,  AUSTIN HEALTH

    发明人： BARTHOLOMEUSZ ANGELINE INGRID ,  LOCARNINI STEPHEN ,  AYRES ANNA ,  LITTLEJOHN MARGARET ,  DESMOND PAUL ,  ANGUS PETER WILLIAM

    IPC分类号： C12N7/01 ,  A61K39/00 ,  C12N15/01 ,  C12N15/36 ,  C12N15/51 ,  C12Q1/70

    CPC分类号： C12N15/86 ,  A61K2039/525 ,  C07K14/005 ,  C12N7/00 ,  C12N2730/10122 ,  C12Q1/706

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus (HBV) variants exhibiting complete or partial resistance to nucleoside or nucleotide analogs and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity to these antibodies. The present invention further contemplates assays for detecting such viral variants, which assays are useful in monitoring anti-viral therapeutic regimens and in developing new or modified vaccines directed against viral agents and in particular HBV variants. The present invention also contemplates the use of the viral variants to screen for and/or develop or design agents capable of inhibiting infection, replication and/or release of the virus.

    摘要翻译： 本发明涉及基因的反弹到病毒变异体表现出降低的对特定药剂和/或与免疫学试剂减少交互的灵敏度。 更具体地，本发明涉及乙型肝炎病毒（HBV）的变体参展完整或部分抗核苷或核苷酸类似物和/或降低的交互性的抗体对病毒表面组分包括减少与抗体合成的灵敏度。 本发明还考虑了用于检测测定法检测病毒变体，其测定是在监测抗病毒治疗方案和在显影针对病毒剂，特别是HBV变异株的新的或修饰的疫苗是有用的。 因此，本发明考虑使用的病毒变异体的筛选和/或开发或设计能够剂感染抑制，复制和/或病毒的释放。