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公开(公告)号：EP0450812B1
公开(公告)日：1994-04-27
申请号：EP91302458.4
申请日：1991-03-21
申请人： Merck & Co., Inc.
发明人： Bergstrom, James D. , Liesch, Jerrold M. , Hensens, Otto D. , Onishi, Janet C. , Huang, Leeyuan , Vanmiddlesworth, Frank L. , Diez, Maria T. , Bartizal, Kenneth F. , Nallin, Mary , Rozdilsky, Walter , Perez, Fernando Pelaez
IPC分类号： C07D493/08 , A61K31/335 , A01N43/24 , C12P17/04
CPC分类号： C07D493/08 , A01N43/90 , C12N9/1085 , C12P9/00 , C12P17/181 , C12R1/645
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公开(公告)号：EP0311193B1
公开(公告)日：1993-12-01
申请号：EP88202137.1
申请日：1988-09-29
申请人： Merck & Co., Inc.
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公开(公告)号：EP0494515A1
公开(公告)日：1992-07-15
申请号：EP91311530.9
申请日：1991-12-11
申请人： MERCK & CO. INC.
发明人： Schwartz, Robert E. , Hallada, Thomas C. , Masurekar, Prakash S. , Hensens, Otto D. , Liesch, Jerrold M. , Sesin, David F.
摘要： A new antibiotic cyclic lipopeptide having the formula
wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.摘要翻译： 描述了具有式CHEM的新型抗生素环状脂肽，其中R是H或OH及其制备方法。 该药剂对人类病原体的活性非常高，哺乳动物的毒性非常低。
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公开(公告)号：EP0256847B1
公开(公告)日：1991-11-21
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
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公开(公告)号：EP0327744A1
公开(公告)日：1989-08-16
申请号：EP88301199.1
申请日：1988-02-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
摘要： Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
摘要翻译： 循环肽是通过对链霉菌（Streptomyces silvensis），ATCC No.55325或ATCC No.55326的受控好氧发酵产生的。这些化合物是催产素的拮抗剂，可用于治疗早产和加压素，因此可用于治疗和预防 可能涉及血管加压素的疾病状态，例如充血性心力衰竭，高血压，水肿和低钠血症。
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公开(公告)号：EP0494515B1
公开(公告)日：1994-09-14
申请号：EP91311530.9
申请日：1991-12-11
申请人： Merck & Co., Inc.
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公开(公告)号：EP0448301A3
公开(公告)日：1992-06-24
申请号：EP91302223.2
申请日：1991-03-15
申请人： MERCK & CO. INC.
发明人： Sesin, David F. , Liesch, Jerrold M. , Fountoulakis, Jimmy M. , Masurekar, Prakash S. , Kaplan, Louis , Wichmann, Carol F.
摘要： A new antibiotic cyclic lipopeptide and a method of producing it are described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
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公开(公告)号：EP0405997A1
公开(公告)日：1991-01-02
申请号：EP90307124.9
申请日：1990-06-29
申请人： MERCK & CO. INC.
发明人： Schwartz, Robert E. , White, Raymond F. , Liesch, Jerrold M. , Hensens, Otto D. , Joshua, Henry , Schmatz, Dennis M. , Tkacz, Jan S. , Kaplan, Louis , Sosa, Margaret S. , Fountoulakis, Jimmy M. , Giacobbe, Robert A. , Masurekar, Prakash S.
摘要： An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity and its production, isolation, and use are described.
摘要翻译： 描述了通过培养作为对人类病原体具有非常高的活性和非常低的哺乳动物毒性的环状脂肽的Zalerion arboricola产生的抗生素，以及其生产，分离和使用。
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9.发明公开
公开(公告)号：EP0322036A1
公开(公告)日：1989-06-28
申请号：EP88202882.2
申请日：1988-12-14
申请人： Merck & Co., Inc.
发明人： Burg, Richard W. , Dulaney, Eugene L. , Hensens, Otto D. , Liesch, Jerrold M. , Ondeyka, John G. , Wichmann, Carol F. , Huang, Leeyuan
IPC分类号： C07J9/00 , C07J31/00 , C07J17/00 , C12P33/00 , A61K31/575
CPC分类号： C07J31/006 , C07J5/00 , C12P33/00
摘要： There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of soil microorganism L-681,512 under controlled fermentation conditions.
摘要翻译： 公开了通过在受控发酵条件下培养土壤微生物L-681,512产生的天然产物的抗炎和抗变性化合物。
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公开(公告)号：EP0256847A3
公开(公告)日：1989-01-04
申请号：EP87307132.8
申请日：1987-08-12
申请人： Merck & Co., Inc.
发明人： Goetz, Michael A. , Schwartz, Cheryl D. , Koupal, Lawrence R. , Liesch, Jerrold M. , Hensens, Otto D. , Freidinger, Roger , Anderson, Paul S. , Pettibone, Douglas J. , Woodruff, Boyd H.
摘要： Cyclic peptides having the formula: are produced by the controlled aerobic fermentation of Streptomyces silvensis , ATCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.
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