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1.发明公开SUBSTITUTED 1-(2H)-ISOQUINOLINONES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS 失效取代的1-（2H）-ISOCHINOLINONE具有酸性官能团作为血管紧张素II拮抗剂。
公开(公告)号：EP0587698A1
公开(公告)日：1994-03-23
申请号：EP92911951.0
申请日：1992-05-06
申请人： MERCK & CO. INC.
发明人： CHAKRAVARTY, Prasun, K. , GREENLEE, William, J. , KIM, Dooseop , MANTLO, Nathan, B. , PATCHETT, Arthur, A. , DE LASZLO, Stephen, E.
CPC分类号： C07D413/10 , C07D217/24 , C07D417/10 , C07D419/10 , C07F9/62
摘要： 1-(2H)-isoquinolinones substituées de la formule structurelle (I), qui sont des antagonistes de l'angiotensine II utiles dans le traitement de l'hypertension et de l'insuffisance cardiaque.
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2.发明公开SUBSTITUTED PYRIDYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 失效取代的吡啶基吡咯，这类制剂含有它们的它们的使用方法
公开(公告)号：EP0859771A1
公开(公告)日：1998-08-26
申请号：EP96942022.0
申请日：1996-10-30
申请人： MERCK & CO., INC.
IPC分类号： A61K31 , A61P1 , A61P3 , A61P7 , A61P9 , A61P11 , A61P19 , A61P29 , A61P31 , A61P37 , A61P43 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention addresses substituted pyridyl pyrroles, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon antagonists and inhibitors of the biosynthesis and action of TNF-α and IL1. The compounds block the action of glucagon at its receptors and thereby decrease the levels of plasma glucose. The instant pyrroles are also inhibitors of TNF-α and IL1 and may be used as antidiabetic agents as well as other cytokine mediated diseases. Cytokine mediated diseases refer to diseases or conditions in which excessive or unregulated production of one or more cytokines occurs. Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) are cytokines produced by a variety of cells, which are involved in immunoregulation and other physiological conditions, such as inflammation.
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3.发明授权2-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 失效2-取代的芳基吡咯类，组合物这样的化合物含有它们及其用途
公开(公告)号：EP0863757B1
公开(公告)日：2003-03-26
申请号：EP96928097.3
申请日：1996-08-08
申请人： MERCK & CO., INC.
发明人： DE LASZLO, Stephen, E. , MANTLO, Nathan, B. , PONTICELLO, Gerald, S. , SELNICK, Harold, G. , LIVERTON, Nigel, J.
IPC分类号： A61K31/44 , A61K31/50 , A61K31/445 , A61K31/495 , A61K31/505 , A61K31/535 , C07D211/68 , C07D211/80 , C07D213/02 , C07D239/02 , C07D401/04 , C07D401/14 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04
摘要： The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved.
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4.发明公开SUBSTITUTED PYRIMIDINONES BEARING ACIDIC FUNCTIONAL GROUPS AS ANGIOTENSIN II ANTAGONISTS 失效与酸性官能团血管紧张素II拮抗剂取代嘧啶酮类。
公开(公告)号：EP0587814A1
公开(公告)日：1994-03-23
申请号：EP92917350.0
申请日：1992-04-24
申请人： MERCK & CO. INC.
发明人： CHAKRAVARTY, Prasun, K. , GREENLEE, William, J. , KIM, Dooseop , MANTLO, Nathan, B. , PATCHETT, Arthur, A.
IPC分类号： A61K31 , A61P9 , A61P43 , C07D473 , C07D475 , C07D487 , C07D491 , C07D495 , C07D498 , C07D513 , C07F9
CPC分类号： C07D487/04 , C07D475/02 , C07D475/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07F9/6561
摘要： De nouvelles pyrimidinones fusionnées et substituées de la formule (I) peuvent être utilisées comme antagonistes d'angiotensine II.
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5.发明公开2,5-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 失效2.5取代的芳基吡咯，含组合物及其用途
公开(公告)号：EP0871444A1
公开(公告)日：1998-10-21
申请号：EP96928099.0
申请日：1996-08-06
申请人： MERCK & CO., INC.
发明人： DE LASZLO, Stephen, E. , MANTLO, Nathan, B. , PONTICELLO, Gerald, S. , SELNICK, Harold, G. , LIVERTON, Nigel, J.
IPC分类号： A61K31 , A61P1 , A61P9 , A61P19 , A61P29 , A61P31 , A61P37 , A61P43 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D471
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D471/04
摘要： The present invention addresses 2,5-substituted aryl pyrroles of formula (I); or pharmaceutically acceptable salts thereof, as well as compositions containing such compounds and methods of treatment. The compounds are useful for treating Cytokine mediated diseases, which refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1(IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved in immunoregulation and other physiological conditions, such as inflammation. The compounds also have glucagon antagonist activity.
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6.发明公开2-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 失效2-取代的芳基吡咯类，组合物这样的化合物含有它们及其用途
公开(公告)号：EP0863757A1
公开(公告)日：1998-09-16
申请号：EP96928097.0
申请日：1996-08-08
申请人： MERCK & CO., INC.
发明人： DE LASZLO, Stephen, E. , MANTLO, Nathan, B. , PONTICELLO, Gerald, S. , SELNICK, Harold, G. , LIVERTON, Nigel, J.
IPC分类号： A61K31 , A61P1 , A61P9 , A61P19 , A61P29 , A61P31 , A61P37 , A61P43 , C07D401 , C07D403 , C07D471
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04
摘要： The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved.
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7.发明公开
公开(公告)号：EP0586513A1
公开(公告)日：1994-03-16
申请号：EP92912039.0
申请日：1992-05-05
申请人： MERCK & CO. INC.
发明人： CHAKRAVARTY, Prasun, K. , GREENLEE, William, J. , KIM, Dooseop , MANTLO, Nathan, B. , PATCHETT, Arthur, A. , ASHTON, Wallace, T. , CHANG, Linda, L.
IPC分类号： A61K31 , A61P9 , A61P25 , A61P27 , C07D209 , C07D249 , C07D271 , C07D285 , C07D291 , C07D401 , C07D403 , C07D405 , C07D413 , C07D417 , C07D419 , C07F9
CPC分类号： C07D413/10 , C07D249/12 , C07D417/10 , C07D419/10
摘要： Nouveaux composés de triazolinone, de triazolinethione et de triazolinimine substitués, de la formule (I), utiles en tant qu'antagonistes de l'angiotensine II.
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公开(公告)号：EP0668864A1
公开(公告)日：1995-08-30
申请号：EP93918159.0
申请日：1993-07-07
申请人： MERCK & CO. INC.
发明人： RIVERO, Ralph, A. , CHAKRAVARTY, Prasun, K. , GREENLEE, William, J. , KEVIN, Nancy, J. , MANTLO, Nathan, B.
CPC分类号： C07D471/04
摘要： Biphenylmethylimidazopyridines of general structure (I) are angiotensin (II) antagonists and therefore useful in the treatment of hypertension and related cardiovascular disorders and ocular hypertension.
摘要翻译： 一般结构（I）的联苯基甲基咪唑并吡啶是血管紧张素（II）拮抗剂，因此可用于治疗高血压和相关的心血管疾病和高眼压症。
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9.发明公开6-AMINO SUBSTITUTED IMIDAZO 4,5-b]PYRIDINES AS ANGIOTENSIN II ANTAGONISTS 失效6-氨基取代IMIDAZO¬4,5-B吡啶ALS血管紧张素II拮抗剂
公开(公告)号：EP0640084A1
公开(公告)日：1995-03-01
申请号：EP93911232.0
申请日：1993-05-11
申请人： MERCK & CO. INC.
发明人： GREENLEE, William, J. , KIM, Dooseop , MANTLO, Nathan, B. , PATCHETT, Arthur, A. , RIVERO, Ralph, A.
CPC分类号： C07D473/00 , C07D471/04 , C07D473/04 , C07D473/30 , C07D473/32 , C07D473/40 , C07F9/6561
摘要： Substituted imidazo[4,5-b]pyridines of structural formula (I) are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
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