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公开(公告)号：EP2134342A2
公开(公告)日：2009-12-23
申请号：EP08726587.2
申请日：2008-03-07
申请人： Merck & Co., Inc.
CPC分类号： C07D471/20 , C07D403/12 , C07D471/10 , C07D519/00
摘要： The present invention is directed to compounds of Formula I: I (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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2.发明授权SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY 失效与癌症REMME SANTANDER和作用CYTOKININHIBIERENDER取代咪唑
公开(公告)号：EP0854870B1
公开(公告)日：2009-06-10
申请号：EP96937654.0
申请日：1996-10-02
申请人： Merck & Co., Inc.
IPC分类号： C07D401/14 , A61K31/415 , A61K31/44 , A61K31/445 , C07D417/14
CPC分类号： C07D401/14 , C07D417/14 , Y02P20/55
摘要： Compounds represented by formula (I), are disclosed. AR represents an aromatic group containing 6-10 atoms; and (a) represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atom. A pharmaceutical composition is also included. Methods of treating cancer and cytokine mediated diseases are also included.
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3.发明公开SPIROPIPERIDINE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHERMER S DISEASE 有权螺哌啶化合物作为阿尔茨海默氏病的治疗β-分泌酶抑制剂
公开(公告)号：EP1804794A2
公开(公告)日：2007-07-11
申请号：EP05812233.4
申请日：2005-10-12
发明人： BARROW, James, C. , COBURN, Craig, A. , EGBERTSON, Melissa, S. , MCGAUGHEY, Georgia, B. , MCWHERTER, Melody, A. , NEILSON, Lou, Anne , SELNICK, Harold, G. , STAUFFER, Shaun, R. , YANG, Zhi-Qiang , YANG, Wenjin , LU, Wanli , FAHR, Bruce , RITTLE, Kenneth, E.
IPC分类号： A61K31/438 , C07D401/04
CPC分类号： C07D471/10
摘要： The present invention is directed to spiropiperidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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4.发明公开1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权用于治疗阿尔茨海默病SUITABLE 1,3,5-取代PHENYLDERIVATVERBINDUNGEN的治疗ALSβ-分泌酶抑制剂
公开(公告)号：EP1740559A1
公开(公告)日：2007-01-10
申请号：EP05738682.3
申请日：2005-04-15
申请人： Merck & Co., Inc.
发明人： BARROW, James, C. , MCGAUGHEY, Georgia, B. , NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , STAUFFER, Shaun, R. , COBURN, Craig, A.
IPC分类号： C07D271/10
CPC分类号： C07D271/10 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/62 , C07D271/06 , C07D285/12 , C07D307/14 , C07D307/42 , C07D307/44 , C07D307/52 , C07D307/54 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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5.发明公开BENZYLETHER AND BENZYLAMINO BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER S DISEASE 有权苄基和苄ASβ-分泌阿尔茨海默氏病的治疗抑制剂
公开(公告)号：EP1689713A1
公开(公告)日：2006-08-16
申请号：EP04811618.0
申请日：2004-11-19
申请人： Merck & Co., Inc.
发明人： NANTERMET, Philippe, G. , RAJAPAKSE, Hemaka, A. , SELNICK, Harold, G. , STAUFFER, Shaun, R. , YOUNG, Mary Beth
IPC分类号： C07D213/02 , A61K31/44
CPC分类号： C07C255/46 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D207/06 , C07D213/76 , C07D295/192 , C07D401/06
摘要： The present invention is directed to benzylether and benzylamino derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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6.发明授权2-SUBSTITUTED ARYL PYRROLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE 失效2-取代的芳基吡咯类，组合物这样的化合物含有它们及其用途
公开(公告)号：EP0863757B1
公开(公告)日：2003-03-26
申请号：EP96928097.3
申请日：1996-08-08
申请人： MERCK & CO., INC.
发明人： DE LASZLO, Stephen, E. , MANTLO, Nathan, B. , PONTICELLO, Gerald, S. , SELNICK, Harold, G. , LIVERTON, Nigel, J.
IPC分类号： A61K31/44 , A61K31/50 , A61K31/445 , A61K31/495 , A61K31/505 , A61K31/535 , C07D211/68 , C07D211/80 , C07D213/02 , C07D239/02 , C07D401/04 , C07D401/14 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04
摘要： The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions in which excessive or unregulated production or activity of one or more cytokines occurs. Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and Tumor Necrosis Factor (TNF) are cytokines which are involved.
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7.发明授权NOVEL N-(2-OXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES 失效N-（2-氧代-2,3,4,5-四氢-1H-1,5-苯并二氮杂-3-基）-3-酰胺
公开(公告)号：EP0833819B1
公开(公告)日：2003-03-26
申请号：EP96916988.7
申请日：1996-06-03
申请人： MERCK & CO., INC.
发明人： CLAREMON, David, A. , FREIDINGER, Roger, M. , LIVERTON, Nigel , SELNICK, Harold, G. , SMITH, Garry, R.
IPC分类号： C07D243/12 , A61K31/55
CPC分类号： C07D243/12
摘要： This invention is concerned with novel compounds represented by structural formula (I), which are useful in the treatment of arrhythmia.
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8.发明公开SUBSTITUTED IMIDAZOLES HAVING ANTI-CANCER AND CYTOKINE INHIBITORY ACTIVITY 失效与癌症REMME SANTANDER和作用CYTOKININHIBIERENDER取代咪唑
公开(公告)号：EP0854870A1
公开(公告)日：1998-07-29
申请号：EP96937654.0
申请日：1996-10-02
申请人： MERCK & CO., INC.
IPC分类号： A61K31 , A61P7 , A61P17 , A61P19 , A61P29 , A61P31 , A61P35 , A61P37 , A61P43 , C07D233 , C07D401 , C07D405 , C07D413 , C07D417
CPC分类号： C07D401/14 , C07D417/14 , Y02P20/55
摘要： Compounds represented by formula (I), are disclosed. AR represents an aromatic group containing 6-10 atoms; and (a) represents a 4 to 10 membered non-aromatic heterocycle containing at least one N atom, and optionally containing 1-2 additional N atoms and 0-1 O or S atom. A pharmaceutical composition is also included. Methods of treating cancer and cytokine mediated diseases are also included.
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9.发明公开NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES 失效新的N-（2,4-二氧代-2,3,4,5-四氢-1H-1,5-苯并二氮杂-3YL）-3-酰胺
公开(公告)号：EP0842156A1
公开(公告)日：1998-05-20
申请号：EP96916954.0
申请日：1996-06-03
申请人： MERCK & CO., INC.
CPC分类号： C07D243/12
摘要： This invention is concerned with novel compounds represented by structural formula (I) which are useful in the treatment of arrhythmia.
摘要翻译： 本发明涉及用于治疗心律失常的由结构式（I）表示的新颖化合物。
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10.发明公开NOVEL N-(1-ALKYL-5-PHENYL-2,3,4,5-TETRAHYDRO-1H-BENZO[B][1,4]DIAZEPIN-3-YL)-ACETAMIDES 失效NEUE N-（1-烷基-5-苯基-2,3,4,5-四氢-1H-苯并[B] [1,4] - 尿嘧啶-3-基） - 乙酰胺
公开(公告)号：EP0830350A1
公开(公告)日：1998-03-25
申请号：EP96920612.0
申请日：1996-06-03
申请人： MERCK & CO., INC.
CPC分类号： C07D243/12
摘要： This invention is concerned with novel compounds represented by structural formula (I) which are useful in the treatment of arrhythmia.
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