公开(公告)号：EP0322937A3

公开(公告)日：1990-12-12

申请号：EP88202603.2

申请日：1988-11-18

申请人： Merck & Co., Inc.

发明人： Goegelman, Robert T. ,  Ondeyka, John G.

IPC分类号： C07D491/22 ,  C12P17/18 ,  A61K31/495

CPC分类号： C07D491/22 ,  A01N43/90 ,  C12P17/188

摘要： Paraherquamide is a fungal metabolite isolated from the known fungus Penicillium paraherquei , and from a newly isolated strain of the fungus Penicillium charlesii . Additional compounds of formula
are disclosed which are related to paraherquamide and have been isolated from Penicillium charlesii . The compounds are potent antiparasitic agents. Compositions including such compounds as the active ingredient thereof for antiparasitic uses against endo and ecto parasites are also disclosed, as well as processes for the preparation of such compounds from the newly isolated fungus.

公开(公告)号：EP0322937A2

公开(公告)日：1989-07-05

申请号：EP88202603.2

申请日：1988-11-18

申请人： Merck & Co., Inc.

发明人： Goegelman, Robert T. ,  Ondeyka, John G.

IPC分类号： C07D491/22 ,  C12P17/18 ,  A61K31/495

CPC分类号： C07D491/22 ,  A01N43/90 ,  C12P17/188

摘要： Paraherquamide is a fungal metabolite isolated from the known fungus Penicillium paraherquei , and from a newly isolated strain of the fungus Penicillium charlesii . Additional compounds of formula
are disclosed which are related to paraherquamide and have been isolated from Penicillium charlesii . The compounds are potent antiparasitic agents. Compositions including such compounds as the active ingredient thereof for antiparasitic uses against endo and ecto parasites are also disclosed, as well as processes for the preparation of such compounds from the newly isolated fungus.

摘要翻译： Paraherquamide是从已知的真菌Penicillium paraherquei和从新分离的真菌青霉菌菌株分离的真菌代谢物。 公开了另外的式CHEM的化合物，其与对甲酰喹啉有关，并且已经从青霉菌中分离出来。 这些化合物是有效的抗寄生虫剂。 还公开了包括其抗寄生虫用于抗寄生虫和寄生虫的活性成分的化合物的组合物，以及从新分离的真菌制备这些化合物的方法。

公开(公告)号：EP0322036A1

公开(公告)日：1989-06-28

申请号：EP88202882.2

申请日：1988-12-14

申请人： Merck & Co., Inc.

发明人： Burg, Richard W. ,  Dulaney, Eugene L. ,  Hensens, Otto D. ,  Liesch, Jerrold M. ,  Ondeyka, John G. ,  Wichmann, Carol F. ,  Huang, Leeyuan

IPC分类号： C07J9/00 ,  C07J31/00 ,  C07J17/00 ,  C12P33/00 ,  A61K31/575

CPC分类号： C07J31/006 ,  C07J5/00 ,  C12P33/00

摘要： There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of soil microorganism L-681,512 under controlled fermentation conditions.

摘要翻译： 公开了通过在受控发酵条件下培养土壤微生物L-681,512产生的天然产物的抗炎和抗变性化合物。

公开(公告)号：EP0322036B1

公开(公告)日：1992-06-17

申请号：EP88202882.2

申请日：1988-12-14

申请人： Merck & Co., Inc.

发明人： Burg, Richard W. ,  Dulaney, Eugene L. ,  Hensens, Otto D. ,  Liesch, Jerrold M. ,  Ondeyka, John G. ,  Wichmann, Carol F. ,  Huang, Leeyuan

IPC分类号： C07J9/00 ,  C07J31/00 ,  C07J17/00 ,  C12P33/00 ,  A61K31/575

CPC分类号： C07J31/006 ,  C07J5/00 ,  C12P33/00

公开(公告)号：EP0478061A1

公开(公告)日：1992-04-01

申请号：EP91202395.9

申请日：1991-09-18

申请人： MERCK & CO. INC.

发明人： Bills, Gerald F. ,  Ondeyka, John G. ,  Hensens, Otto D. ,  Zink, Deborah L. ,  Koupal, Lawrence ,  Lingham, Russell B.

IPC分类号： C07D209/70 ,  A61K31/40

CPC分类号： C07D209/76 ,  C12P17/10

摘要： An antiviral agent produced by Hypoxylon fragiforme and having the structure:

is described. The product has high activity as an HIV protease enzyme inhibitor and is useful in the treatment of diseases in which control of HIV protease activity is desirable.

摘要翻译： 描述了由Hypoxylon fragiforme生产并具有以下结构的抗病毒剂：。 该产品作为HIV蛋白酶抑制剂具有高活性，并且可用于治疗其中需要控制HIV蛋白酶活性的疾病。