公开(公告)号：EP0737196A1

公开(公告)日：1996-10-16

申请号：EP95904990.0

申请日：1994-12-22

申请人： MERCK FROSST CANADA INC.

发明人： YOUNG, Robert, N. ,  LABELLE, Marc ,  LEBLANC, Yves ,  LAU, Cheuk, K. ,  DUFRESNE, Claude ,  GAREAU, Yves ,  XIANG, Yi, Bin

IPC分类号： C07D513 ,  A61K31 ,  A61K45 ,  A61P11 ,  A61P27 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D491 ,  C07D495

CPC分类号： C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

公开(公告)号：EP0885243A1

公开(公告)日：1998-12-23

申请号：EP97907690.0

申请日：1997-02-19

申请人： MERCK & CO., INC. ,  MERCK FROSST CANADA INC.

发明人： NICHOLSON, Donald, W. ,  FAZIL, Kimberly, A. ,  GALLANT, Michel ,  GAREAU, Yves ,  LABELLE, Marc ,  RASPER, Dita, M. ,  RUEL, Rejean ,  VAILLANCOURT, John, P. ,  BECKER, Joseph, W. ,  ROTONDA, Jennifer ,  THORNBERRY, Nancy, A. ,  PETERSON, Erin, P.

IPC分类号： C12N15 ,  C07K5 ,  C07K14 ,  C12N1 ,  C12N9 ,  A61K38 ,  C12R1

CPC分类号： C12N9/6475 ,  A61K38/00 ,  C07K5/1021

摘要： The invention relates to crystallized apopain, the use of that structure to solve the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopain structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.

公开(公告)号：EP0840728A1

公开(公告)日：1998-05-13

申请号：EP96923210.0

申请日：1996-06-03

申请人： MERCK FROSST CANADA INC.

发明人： GAREAU, Yves ,  LABELLE, Marc ,  DUFRESNE, Claude ,  YERGEY, James ,  CHAURET, Nathalie ,  NICOLI-GRIFFITH, Deborah ,  TRIMBLE, Laird ,  XU, Xin

IPC分类号： C07D215 ,  A61K31 ,  A61P1 ,  A61P7 ,  A61P9 ,  A61P11 ,  A61P13 ,  A61P15 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D495

CPC分类号： C07D495/04 ,  C07D215/18

摘要： Compounds of formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

公开(公告)号：EP0809630A1

公开(公告)日：1997-12-03

申请号：EP96901667.0

申请日：1996-02-08

申请人： MERCK FROSST CANADA, INC.

发明人： GALLANT, Michel ,  GAREAU, Yves ,  GUAY, Daniel ,  LABELLE, Marc ,  PRASIT, Petpiboon

IPC分类号： C07D401 ,  A61K31 ,  A61P11 ,  A61P25 ,  A61P27 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D209 ,  C07D403 ,  C07D405 ,  C07D409

CPC分类号： C07D209/14 ,  C07D209/26

摘要： Disclosed are indole derivatives of formula (I) having activity on the cannabinoid receptors and the methods of their preparation. The compounds are useful for lowering ocular intraocular pressure and treating glaucoma because of the activity of the cannabinoid receptor.