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公开(公告)号：EP1148877A1
公开(公告)日：2001-10-31
申请号：EP99970321.8
申请日：1999-10-12
发明人： HARADA, Shun-Ichi , MACHWATE, Mohamed , RODAN, Gideon, A. , LABELLE, Marc , METTERS, Kathleen , YOUNG, Robert, N.
IPC分类号： A61K31/41 , A61K31/66 , A61K31/415 , A61K31/675
CPC分类号： G01N33/88 , A61K31/00 , A61K31/4196 , A61K31/66 , A61K45/06 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要： The present invention relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an EP4 receptor subtype antagonist.
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公开(公告)号：EP0840728A1
公开(公告)日：1998-05-13
申请号：EP96923210.0
申请日：1996-06-03
发明人： GAREAU, Yves , LABELLE, Marc , DUFRESNE, Claude , YERGEY, James , CHAURET, Nathalie , NICOLI-GRIFFITH, Deborah , TRIMBLE, Laird , XU, Xin
IPC分类号： C07D215 , A61K31 , A61P1 , A61P7 , A61P9 , A61P11 , A61P13 , A61P15 , A61P29 , A61P37 , A61P43 , C07D495
CPC分类号： C07D495/04 , C07D215/18
摘要： Compounds of formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
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公开(公告)号：EP0809630A1
公开(公告)日：1997-12-03
申请号：EP96901667.0
申请日：1996-02-08
IPC分类号： C07D401 , A61K31 , A61P11 , A61P25 , A61P27 , A61P29 , A61P37 , A61P43 , C07D209 , C07D403 , C07D405 , C07D409
CPC分类号： C07D209/14 , C07D209/26
摘要： Disclosed are indole derivatives of formula (I) having activity on the cannabinoid receptors and the methods of their preparation. The compounds are useful for lowering ocular intraocular pressure and treating glaucoma because of the activity of the cannabinoid receptor.
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公开(公告)号：EP1263728A2
公开(公告)日：2002-12-11
申请号：EP01913422.0
申请日：2001-03-02
IPC分类号： C07D209/04 , C07D401/04 , A61P29/00
CPC分类号： C07D401/12 , C07D209/42 , C07D401/14 , C07D403/12
摘要： Compounds represented by formula (I), as well as pharmaceutically acceptable salts and hydrates thereof are disclosed as useful for treating or preventing diseases and conditions mediated by PDE-IV. Pharmaceutical compositions and methods of treatment are also included.
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公开(公告)号：EP1119555A1
公开(公告)日：2001-08-01
申请号：EP99970085.9
申请日：1999-10-05
IPC分类号： C07D225/08 , A61K31/395 , C07D409/12
CPC分类号： C07D409/12 , C07D225/08
摘要： The present invention relates to biphenylene lactams of Formula (II) which are ligands at the prostaglandin receptors, as well as a method for treating prostaglandin mediated diseases comprising administration to a patient in need of such a treatment of a non-toxic therapeutically effective amount of compound of Formula (II), and the like.
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公开(公告)号：EP0737196A1
公开(公告)日：1996-10-16
申请号：EP95904990.0
申请日：1994-12-22
发明人： YOUNG, Robert, N. , LABELLE, Marc , LEBLANC, Yves , LAU, Cheuk, K. , DUFRESNE, Claude , GAREAU, Yves , XIANG, Yi, Bin
CPC分类号： C07D491/04 , C07D495/04 , C07D513/04
摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
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7.发明授权CYCLOPENTANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权环孢菌素，维生素DERARTIGE VERBINDUNGEN ENTHALTEND UND BEHANDLUNGSMETHODEN
公开(公告)号：EP1305286B1
公开(公告)日：2004-12-08
申请号：EP01955162.1
申请日：2001-07-23
发明人： LABELLE, Marc , STURINO, Claudio , ROY, Bruno , BERTHELETTE, Carl , BOYD, Michael , LACHANCE, Nicolas , SCHEIGETZ, John
IPC分类号： C07D209/80
CPC分类号： H04W52/46 , C07D209/94 , H04B17/318 , H04W48/04 , H04W48/20 , H04W52/04 , H04W52/146 , H04W52/24 , H04W52/245 , H04W52/247 , H04W52/288
摘要： Substituted cyclopentanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.
摘要翻译： 取代的环戊烯吲哚衍生物是前列腺素的拮抗剂，因此可用于治疗前列腺素介导的疾病。
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8.发明公开
公开(公告)号：EP0699188A1
公开(公告)日：1996-03-06
申请号：EP94916105.0
申请日：1994-05-19
发明人： LABELLE, Marc , LEBLANC, Yves , BELLEY, Michel , GRIMM, Erich, L. , GUAY, Daniel , XIANG, Yi, Bin
CPC分类号： C07D215/18
摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
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9.发明公开CYCLOPENTANOINDOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权CYCLPENTANOINDOLE，混合含有这类化合物和治疗方法
公开(公告)号：EP1305286A2
公开(公告)日：2003-05-02
申请号：EP01955162.1
申请日：2001-07-23
发明人： LABELLE, Marc , STURINO, Claudio , ROY, Bruno , BERTHELETTE, Carl , BOYD, Michael , LACHANCE, Nicolas , SCHEIGETZ, John
IPC分类号： C07D209/80
CPC分类号： H04W52/46 , C07D209/94 , H04B17/318 , H04W48/04 , H04W48/20 , H04W52/04 , H04W52/146 , H04W52/24 , H04W52/245 , H04W52/247 , H04W52/288
摘要： Substituted cyclopentanoindole derivatives are antagonists of prostaglandins, and as such are useful for the treatment of prostaglandin mediated diseases.
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公开(公告)号：EP0885243A1
公开(公告)日：1998-12-23
申请号：EP97907690.0
申请日：1997-02-19
发明人： NICHOLSON, Donald, W. , FAZIL, Kimberly, A. , GALLANT, Michel , GAREAU, Yves , LABELLE, Marc , RASPER, Dita, M. , RUEL, Rejean , VAILLANCOURT, John, P. , BECKER, Joseph, W. , ROTONDA, Jennifer , THORNBERRY, Nancy, A. , PETERSON, Erin, P.
CPC分类号： C12N9/6475 , A61K38/00 , C07K5/1021
摘要： The invention relates to crystallized apopain, the use of that structure to solve the structure of apopain homologues and other crystal forms of apopain, mutants and co-complexes of apopain, and the use of the apopain structure and that of its homologues, mutants, and co-complexes to design modulators of apopain.
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