公开(公告)号：EP1021429A1

公开(公告)日：2000-07-26

申请号：EP98947246.9

申请日：1998-10-01

申请人： MERCK FROSST CANADA INC.

发明人： PERRIER, Helene ,  HAN, Yongxin ,  BAYLY, Christopher ,  MacDONALD, Dwight ,  GIROUX, Andre ,  YOUNG, Robert, N.

IPC分类号： C07D307/42 ,  A61K31/34 ,  C07D307/38 ,  C07D307/46 ,  C07D307/54 ,  C07D307/56 ,  C07D307/64 ,  C07D307/66 ,  C07D473/38 ,  C07D405/04 ,  C07D405/12 ,  C07D417/12 ,  C07D413/12 ,  C07D405/06 ,  C07F7/08

CPC分类号： C07D307/42 ,  C07D307/46 ,  C07D307/54 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07F7/0814

摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).