专利检索 ap:("MERCK FROSST CANADA INC.") AND inv:"HAN, Yongxin" 第 1 页

1.

发明公开
2-PYRROLIDONES AS EP4 RECEPTOR AGONISTS 审中-公开
标题翻译： -2-吡咯烷酮作为EP4受体激动剂

公开(公告)号：EP1558602A2

公开(公告)日：2005-08-03

申请号：EP03809227.6

申请日：2003-10-23

申请人： MERCK FROSST CANADA INC.

发明人： BILLOT, Xavier , BEUNARD, Jean-Luc , HAN, Yongxin , YOUNG, Robert, N. , COLUCCI, John , GIRARD, Mario , WILSON, Marie-Claire

IPC分类号： C07D403/06

CPC分类号： C07D403/06

摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors of Formula (I), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

2.

发明公开
3,4-DIARYL-2-HYDROXY-2,5-DIHYDROFURANS AS PRODRUGS TO COX-2 INHIBITORS 失效
标题翻译： 3,4-二芳基-2-羟基-2,5-二氢呋喃作为COX-2抑制剂的活性成分的前体

公开(公告)号：EP0904269A1

公开(公告)日：1999-03-31

申请号：EP96934267.0

申请日：1996-10-29

申请人： MERCK FROSST CANADA INC.

发明人： BLACK, Cameron , LEGER, Serge , PRASIT, Petpiboon , WANG, Zhaoyin , HAMEL, Pierre , HAN, Yongxin , HUGHES, Gregory

IPC分类号： C07D317 , A61K31 , A61P29 , A61P43 , C07C317 , C07C323 , C07D213 , C07D307 , C07D405 , C07D409 , C07D417 , C07F9

CPC分类号： C07D307/32 , C07C317/22 , C07C323/64 , C07D213/34 , C07D307/30 , C07D307/58 , C07D307/60 , C07D307/62 , C07D307/64 , C07D307/66 , C07D307/68 , C07D307/94 , C07D405/04 , C07D405/12 , C07D409/12 , C07D417/12 , C07F9/117

摘要： The invention encompasses the novel compound of formula (I) useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of formula (I).

3.

发明公开
1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA 有权
标题翻译： 1.5二取代吡咯-2-酮衍生物FOR USE AS EP4受体激动剂等眼疾病治疗AS 青光眼

公开(公告)号：EP1513589A1

公开(公告)日：2005-03-16

申请号：EP03727099.8

申请日：2003-06-02

申请人： MERCK FROSST CANADA INC.

发明人： BILLOT, Xavier , YOUNG, Robert, N. , HAN, Yongxin

IPC分类号： A61P27/06 , A61K31/4015 , A61K31/41 , C07D403/12

CPC分类号： A61K31/41 , A61K31/4015 , A61K45/06 , C07D403/12 , A61K2300/00

摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors of formula (I), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of the patient.

4.

发明公开
ARYL FURAN DERIVATIVES AS PDE IV INHIBITORS 审中-公开
标题翻译：芳基 - 呋喃衍生物作为PDE IV抑制剂

公开(公告)号：EP1021429A1

公开(公告)日：2000-07-26

申请号：EP98947246.9

申请日：1998-10-01

申请人： MERCK FROSST CANADA INC.

发明人： PERRIER, Helene , HAN, Yongxin , BAYLY, Christopher , MacDONALD, Dwight , GIROUX, Andre , YOUNG, Robert, N.

IPC分类号： C07D307/42 , A61K31/34 , C07D307/38 , C07D307/46 , C07D307/54 , C07D307/56 , C07D307/64 , C07D307/66 , C07D473/38 , C07D405/04 , C07D405/12 , C07D417/12 , C07D413/12 , C07D405/06 , C07F7/08

CPC分类号： C07D307/42 , C07D307/46 , C07D307/54 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07F7/0814

摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).